Plasma Epinephrine and Norepinephrine Levels during Anesthesia: Enflurane-N2O-O2 Compared with Fentanyl-N2O-O2

Brown, Freeman F.; Owens, William D.; Felts, James A.; Spitznagel, Edward L.; Cryer, Philip E.

doi:10.1097/00132586-198212000-00025

Cited by 11 publications

(6 citation statements)

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“…Our finding that upper abdominal surgery in unblocked patients produced an increase in plasma adrenaline and noradrenaline concentrations is in accordance with previous reports (Halter, Pflug and Porte, 1977;Brown et al, 1982). As described by these authors, we also found high concentrations of both plasma adrenaline and noradrenaline more than 2 h after the end of operation.…”

Section: Discussionsupporting

confidence: 93%

Effects of the Extradural Administration of Morphine or Bupivacaine, on the Metabolic Response to Upper Abdominal Surgery

Håkanson¹,

Rutberg²,

Jorfeldt³

et al. 1985

British Journal of Anaesthesia

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The influence of thoracic extradural local anaesthetics (0.5% bupivacaine) or extradural morphine on the metabolic response to upper abdominal surgery was compared with the administration of morphine i.v. in the period after operation. The extradural local anaesthetic group had significantly lower blood glucose and plasma FFA concentrations and consistently, but not significantly, lower blood glycerol and lactate concentrations than both the other groups. At 4 h both extradural groups had significantly lower plasma FFA and blood 3-hydroxybutyrate concentrations than the control group. Blood alanine concentration decreased in all three groups with a minimum at 24 h. There were no differences in serum insulin concentrations between the groups. It is concluded that thoracic extradural morphine differs from thoracic extradural local anaesthetics in being much less able to suppress the metabolic response associated with upper abdominal surgery.

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Section: Discussionsupporting

confidence: 93%

Effects of the Extradural Administration of Morphine or Bupivacaine, on the Metabolic Response to Upper Abdominal Surgery

Håkanson¹,

Rutberg²,

Jorfeldt³

et al. 1985

British Journal of Anaesthesia

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“…Halter, Pflug and Porte (1977) demonstrated a consistent increase in plasma catecholamine concentrations occurring immediately after surgical incision in patients anaesthetized with nitrous oxide and halothane in oxygen with neuromuscular blockade obtained with pancuronium. These observations have been confirmed subsequently by several groups of investigators (Brismar et al, 1982;Brown et al, 1982;Ponten et al, 1982;Hamberger and Jandberg, 1983).…”

Section: Non-cardiac Surgerysupporting

confidence: 58%

“…There seems to be agreement that supplementation of general anaesthesia with low dose fentanyl (<10/xgkg~l) does not confer any advantage over supplementation with either enflurane or halothane in that the increases in plasma catecholamine concentrations are of a similar magnitude (Brismar et al, 1982;Hamberger and Jandberg, 1983). Although it has been suggested that enflurane supplementation may cause greater suppression of the sympathoadrenal response to surgery than low dose fentanyl (Brown et al, 1982), this has been questioned in subsequent correspondence (McLeskey, 1982). No data are currently available comparing the effects of halothane with enflurane.…”

Section: Non-cardiac Surgerymentioning

confidence: 99%

Sympathoadrenal Responses to Anaesthesia and Surgery

Derbyshire

Smith

1984

British Journal of Anaesthesia

149

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“…Halothane, enflurane, and isoflurane attenuated the action potentials of peripheral sympathetic nerves and/or lowered blood NE levels [17][18][19]. Diethyl ether, cyclopropane, and nitrous oxide, on the other hand, stimulated such activity and/or elevated blood NE levels [20,21].…”

Section: Discussionmentioning

confidence: 99%

Subanesthetic sevoflurane does not affect sympathetic or parasympathetic function

Kuramochi

1994

J Anesth

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To evaluate the effects of subanesthetic enflurane and sevoflurane on the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS), the blood level of norepinephrine (NE) and fluctuations in the R-R intervals were measured on electrocardiogram in humans given either 0.5 MAC enflurane or sevoflurane. Enflurane suppressed circulating plasma NE and elevated coefficients of variation (CV) of R-R intervals after 20 and 30 min of inhalation. In contrast, 0.5 MAC of sevoflurane slightly stimulated cardiovascular function without any change in blood NE. Sevoflurane lowered the CV to 84% of control after 30 min of inhalation. These results indicate that subanesthetic concentrations of sevoflurane are unlikely to perturb sympathetic and parasympathetic activities in humans without surgical stimulation when compared with enflurane.

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Plasma Epinephrine and Norepinephrine Levels during Anesthesia: Enflurane-N2O-O2 Compared with Fentanyl-N2O-O2

Cited by 11 publications

References 0 publications

Effects of the Extradural Administration of Morphine or Bupivacaine, on the Metabolic Response to Upper Abdominal Surgery

Effects of the Extradural Administration of Morphine or Bupivacaine, on the Metabolic Response to Upper Abdominal Surgery

Sympathoadrenal Responses to Anaesthesia and Surgery

Subanesthetic sevoflurane does not affect sympathetic or parasympathetic function

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