Plasma esterase activities in young and old patients undergoing open inguinal hernia repair

Abou-Hatab, Khaled; O'Mahony, M Sinead; Patel, Sarju; Carey, Declan; Woodhouse, K.W.

doi:10.1016/s0167-4943(00)00073-x

Cited by 15 publications

(11 citation statements)

References 11 publications

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“…Samples of the obliquus internus abdominis muscle were collected from patients who underwent hernia surgery at the Medical University Clinic in Gdansk. The current literature reports that a hernia has no effect on enzyme activity (25) in the adjacent skeletal muscle. Furthermore, any potential effects of a hernia on enzyme activity should be similar between children and adults.…”

Section: Methodsmentioning

confidence: 79%

Anaerobic and Aerobic Enzyme Activities in Human Skeletal Muscle from Children and Adults

et al. 2005

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Literature has shown that children have lower anaerobic capacity and oxidize more lipids during aerobic activity compared with adults. The purpose of the present study was to examine the effects of age on the activity of marker enzymes for anaerobic and aerobic metabolism in human skeletal muscle from relatively sedentary children and adults. The m. obliquus internus abdominis was analyzed for anaerobic [creatine kinase, adenylate kinase, and lactate dehydrogenase (LDH)] and aerobic (carnitine palmitoyltransferase and 2-oxoglutarate dehydrogenase) enzyme activities in 32 male individuals. The subjects were divided into two groups: children (3-11 y; n ϭ 20) and adults (29 -54 y; n ϭ 12). LDH activity was higher in adults (118.2 Ϯ 20.1) compared with children (27.8 Ϯ 10.1) mol · min Ϫ1 · g Ϫ1 wet weight (p Ͻ 0.0002). Creatine kinase activity was 28% (p Ͻ 0.0003) lower in children than in adults, and adenylate kinase activity was 20% (p Ͻ 0.006) lower in children than in adults. In addition, we found higher 2-oxoglutarate dehydrogenase activity in adults compared with children (p Ͻ 0.04), with no effect of age on carnitine palmitoyltransferase activity (NS). When samples were expressed relative to protein content, only LDH activity remained significantly lower in children compared with adults (p Ͻ 0.0001). In conclusion, the lower LDH activity observed in children compared with adults may partially explain decreased anaerobic and lactate generation capacity of the children studied. However, the mechanisms for the relatively deficient anaerobic enzyme activities of children are not clear. The functional characteristics of human skeletal muscle are partially dependent on fiber type; however, modifications to the nature and the capacity of the energy-delivering metabolic pathways can occur independent of fiber type. It is widely known that metabolic enzymes in skeletal muscle have the ability to respond to physiologic stimuli such as exercise (1-4), as well as pathologic processes such as muscular dystrophy, acute respiratory failure, mitochondrial myopathy, denervation, and inactivity (5-9). Although there is some controversy regarding fiber type differences between children and adults (10 -13), there are only minor increases in the proportion of type II fibers with age (10 -12), with no difference in ultrastructure (13). Moreover, there is still disagreement over the effect of age on the enzymatic capacity of skeletal muscle, particularly during the maturation from the pediatric to the adult age group.It has been reported that phosphofructokinase (PFK) was 3-fold lower in the skeletal muscle of children (11-13 y) compared with adults (24 -52 y); however, succinate dehydrogenase activity was not significantly altered by age (11,14). Other studies that have examined anaerobic enzyme activity in children have reported lower glycolytic [PFK, lactate dehydrogenase (LDH)] and higher aerobic (succinate dehydrogenase, fumarase) enzyme activities in children compared with younger adults (14,15). In contrast, one report demon...

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Section: Methodsmentioning

confidence: 79%

Anaerobic and Aerobic Enzyme Activities in Human Skeletal Muscle from Children and Adults

et al. 2005

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“…Plasma aspirin esterase activity is significantly reduced in elderly people either following emergency and elective hip frac‐ture patients on admission to hospital and improves towards normal during subsequent recovery [45]. The effect of trauma on enzymes of drug metabolism may be related to the amount of injury, as relatively minor surgical interventions such as inguinal hernia repair are not associated with decrements in drug metabolism in man [46]. Other illnesses, which cause substantial acute inflammatory responses such as pneumonia, have also been found to be associated with reduced esterase activities in older patients [47].…”

Section: Frailty Esterases and Ageingmentioning

confidence: 99%

Drug metabolism and ageing

Kinirons

O'Mahony

2004

Brit J Clinical Pharma

197

101

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Important changes in drug metabolism occur with ageing. Age-associated reductions in function of some but not all cytochrome P450 enzymes (CYPs) have been described. Induction and inhibition of CYPs needs to be revisited in light of recent advances. The function and pharmacology of transporters have not yet been examined for an age-related effect. Finally, the concept of frailty is being underpinned by studies documenting a decline in drug metabolism and changes in disposition in frail older people compared with either healthy elderly or the young.

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“…Response to anaesthesia and surgery has also been reported to result in reduced activity of plasma aspirin esterase activity [13,14]. The amount of injury would appear to, at least in part, determine effect on enzymatic activity, given the observation that, in contradistinction to hip replacement after fractured neck of femur, inguinal herniorraphy was not associated with reduction in plasma aspirin esterase activity [15].…”

Section: Diseasesmentioning

confidence: 99%

Aspirin esterase(s) – Much known, more to learn

Adebayo

2010

J Pediatr Biochem

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Plasma esterase activities in young and old patients undergoing open inguinal hernia repair

Cited by 15 publications

References 11 publications

Anaerobic and Aerobic Enzyme Activities in Human Skeletal Muscle from Children and Adults

Anaerobic and Aerobic Enzyme Activities in Human Skeletal Muscle from Children and Adults

Drug metabolism and ageing

Aspirin esterase(s) – Much known, more to learn

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