Plasma exchange in selected patients with juvenile rheumatoid arthritis

Brewer, Earl J.; Nickeson, Robert W.; Rossen, Roger D.; Person, Donald A.; Giannini, Edward H.; Milam, John D.

doi:10.1016/s0022-3476(81)80634-8

Cited by 29 publications

(5 citation statements)

References 18 publications

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“…The literature contains reports of mor bidity and mortality associated with TPE [1][2][3][4][5][6][7][8][9]; however, there are few published studies which specifically address the nature and incidence of complications associated with this method of therapy. In the series of TPEs which we have reviewed complica tions were present in 1.6% of the procedures and involved 11% of the patients.…”

Section: Discussionmentioning

confidence: 99%

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The Complications of Therapeutic Plasma Exchange

Ziselman¹,

Bongiovanni²,

Wurzel³

1984

Vox Sanguinis

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We reviewed a series of 181 patients who were treated with therapeutic plasma exchange (TPE) a total of 1,389 times. Complications were associated with 22 (1.6%) of the procedures and involved 20 (11%) of the patients. Six of the complications were of a technical nature and did not affect the medical conditions of the patients. 8 patients developed the following serious medical problems: unexplained death during the post-TPE period, myocardial infarction, pulmonary embolus, loss of consciousness, myocardial ischemia, cerebral ischemia and chest pain. Although these problems were temporally associated with TPE, none of them could be attributed to the TPE with certainty. The remaining eight medical complications were of a less serious nature.

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Section: Discussionmentioning

confidence: 99%

“…While the procedure is generally well tolerated, there have been reports of morbid ity and mortality associated with TPE [1][2][3][4][5][6][7][8][9]. The risks and complications of TPE have not been adequately evaluated.…”

mentioning

confidence: 99%

The Complications of Therapeutic Plasma Exchange

Ziselman¹,

Bongiovanni²,

Wurzel³

1984

Vox Sanguinis

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“…There are two examples of intravenous infusion of unusual microaggregated particles causing severe adverse reactions in patients. One case of a 14‐year‐old girl was briefly described in a report by Brewer and associates in 1981 26 . The other case is referenced in a letter to the editor in a 1983 issue of Lancet 27 .…”

Section: Potential Risk Of Wpm To Patientsmentioning

confidence: 99%

White particulate matter: report of the ad hoc industry review group

et al. 2004

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(1) WPM is not new, can be prevented, and can be removed. (2) WPM contains PLTs, white blood cells, fibrin, and cellular debris. (3) Changes in blood handling are not necessary. (4) WPM may be more frequent when higher g forces are used in component preparation. (5) Enhanced visual inspection of blood components need not be continued. (6) It appears that WPM may not form in RBC collected using automated devices. (7) WPM did not pose a risk to patients but should be avoided.

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“…That embolization is not confined to patients with arte¬ riovenous shunts is dramatically illustrated by a fatal episode of pul¬ monary microembolism in a 14-yearold child with rheumatoid arthritis who was undergoing exchange through a large-bore venous cathe¬ ter. 45 Fatal, acute pulmonary edema has occurred during plasma exchange.…”

Section: Cardiovascular Complicationsmentioning

confidence: 99%