Plasma exchange therapy for endotoxin shock in puppies

Muraji, Toshihiro; Okamoto, Eizo; Hoque, Shafiqul; Toyosaka, Akihiro

doi:10.1016/0022-3468(86)90016-3

Cited by 17 publications

(6 citation statements)

References 10 publications

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“…The use of TPE to treat animal models of sepsis has been reported but results have been conflicting. Muraji et al found improved survival in endotoxemic dogs treated with TPE . Increased mortality in dogs with peritonitis and treated with TPE was reported by Natanson et al; however, this study has been criticized because the septic shock was not treated using conventional therapy (fluids, pressors, etc.)…”

Section: Introductionmentioning

confidence: 84%

Role of therapeutic apheresis in infectious and inflammatory diseases: Current knowledge and unanswered questions

Sloan

Andrzejewski

Aqui

et al. 2014

J of Clinical Apheresis

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Apheresis can remove pathogens and mediators that contribute to pathogenic inflammatory responses in diseases not generally considered to be "Hematologic." Erythrocytapheresis can remove intracellular pathogens such as Babesiosis. Plasmapheresis can remove mediators of the inflammatory response in conditions such as sepsis, chronic autoimmune urticaria and malignant pertussis. Leukapheresis can remove potentially harmful leukocytes in Crohn's Disease and malignant pertussis. While apheresis can remove all of these substances, the clinical efficacy and pathophysiologic changes that occur during apheresis in these conditions are largely unknown. Hence, the clinical utility of apheresis in these conditions is largely unknown and research in these areas has the potential to benefit many patients with a variety of diseases.

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Section: Introductionmentioning

confidence: 84%

Role of therapeutic apheresis in infectious and inflammatory diseases: Current knowledge and unanswered questions

Sloan

Andrzejewski

Aqui

et al. 2014

J of Clinical Apheresis

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“…ET is released into blood by ET translocation with or without infection, inducing hypercytokinaemia and worsening patients' conditions. The clinical effectiveness of removing ET from blood using extracorporeal circulation by PE (8), direct hemoperfusion column containing activated charcoal (9), and direct hemoperfusion adsorption column (PMX) (4) has been widely reported. Alternatively, Lixelle columns selectively adsorb BMG and have been used widely to treat clinically DRA (5).…”

Section: Discussionmentioning

confidence: 99%

Adsorption of Endotoxin by Beta₂‐Microglobulin Adsorbent Column (Lixelle): The New Approach for Endotoxinemia

Tsuchida

Takemoto

Sugimura

et al. 2002

Therapeutic Apheresis

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We previously reported that Lixelle, which was used for beta 2 -microglobulin (BMG) adsorption columns, could adsorb not only BMG but also inflammatory cytokines. We became interested in the application of Lixelle for patients with endotoxinemia and researched its ability to adsorb microorganism components in vitro using lipopolysaccharide (LPS) (Escherichia coli B8), endotoxin (ET) contaiminated water. The initial concentrations of each water solution were LPS (ET 29,135 EU/L) and contaminated water (ET 3,523 EU/L) whole blood solution was LPS (ET 1,197.6 EU/L). Each 2.5 ml of the stock solution and adjusted diluted solutions contained 0.5 ml of Lixelle beads. After shaking at 37°C for 2 h, ET in the

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“…The removal of ET in the blood using extracorporeal circulation is carried out by plasma exchange (7), direct hemoperfusion column containing activated charcoal (8), and direct hemoperfusion adsorption column for ET removal with polymyxin B (Toraymyxin: PMX, Toray Medical, Osaka, Japan) (9), and their clinical effectiveness was reported. These methods were developed to obtain a constant effect by directly removing ET itself, which is a causal substance.…”

Section: Discussionmentioning

confidence: 99%

Adsorption of Microorganism Components by Lixelle Beads

et al. 2000

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We reported previously that Lixelle, which was used for beta-2 microglobulin (BMG) adsorption columns, could adsorb not only BMG but also inflammatory cytokines. We then were interested in the application of Lixelle to patients with systemic inflammatory response syndrome (SIRS) and tried to find out its ability to adsorb microorganism components in vitro using lipopolysaccharide (LPS) (E. coli: B8), endotoxin (ET) containing water, and peptidoglycan (PG: Micrococcus luteus). The initial concentrations of each solution were LPS (ET: 29,135 EU/L), contaminated water (ET: 3,523 EU/L), and PG (67.1 ng/ml) and 2.5 ml of each of the stock solutions and adjusted diluted solutions contained 0.5 ml of Lixelle beads. After shaking at 37 degrees C for 2 h, ET in the solutions was determined by the ET specific-limulus amebocyte lysate (ES-LAL) method and PG by the silkworm larbae plasma (SLP) method. The results revealed that even when ET concentrations in LPS and contaminated water were high, the samples containing Lixelle beads showed significant decreases. There was some adsorption of PG but no significant differences. Thus, Lixelle beads can adsorb not only BMG but also microorganism components such as ET and PG. These findings, together with the ability to adsorb inflammatory cytokines by Lixelle, show the possibility of application for the treatment of infectious SIRS.

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Plasma exchange therapy for endotoxin shock in puppies

Cited by 17 publications

References 10 publications

Role of therapeutic apheresis in infectious and inflammatory diseases: Current knowledge and unanswered questions

Role of therapeutic apheresis in infectious and inflammatory diseases: Current knowledge and unanswered questions

Adsorption of Endotoxin by Beta₂‐Microglobulin Adsorbent Column (Lixelle): The New Approach for Endotoxinemia

Adsorption of Microorganism Components by Lixelle Beads

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Plasma exchange therapy for endotoxin shock in puppies

Cited by 17 publications

References 10 publications

Role of therapeutic apheresis in infectious and inflammatory diseases: Current knowledge and unanswered questions

Role of therapeutic apheresis in infectious and inflammatory diseases: Current knowledge and unanswered questions

Adsorption of Endotoxin by Beta2‐Microglobulin Adsorbent Column (Lixelle): The New Approach for Endotoxinemia

Adsorption of Microorganism Components by Lixelle Beads

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Product

Resources

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Adsorption of Endotoxin by Beta₂‐Microglobulin Adsorbent Column (Lixelle): The New Approach for Endotoxinemia