Plasma extracellular vesicle microRNA‐491‐5p as diagnostic and prognostic marker for head and neck squamous cell carcinoma

Panvongsa, Wittaya; Siripoon, Teerada; Worakitchanon, Wittawin; Arsa, Lalida; Trachu, Narumol; Jinawath, Natini; Ngamphaiboon, Nuttapong; Chairoungdua, Arthit

doi:10.1111/cas.15067

Cited by 20 publications

(11 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study found that increased plasma EVs miR-491-5p levels were associated with poor overall survival and disease-free survival in HNSCC patients. Plasma EVs miR-491-5p was able to distinguish HNSCC patients with sensitivity and specificity of 46.6% and 100%, respectively [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Plasma Extracellular Vesicles-Derived miR-99a-5p: A Potential Biomarker to Predict Early Head and Neck Squamous Cell Carcinoma

Huang

Shen

Hsueh

et al. 2022

Pathol. Oncol. Res.

View full text Add to dashboard Cite

Purpose: This study aimed to investigate the applicability of plasma extracellular vesicles (EVs) miR-99a-5p as a potential head and neck squamous cell carcinoma (HNSCC) diagnostic biomarker.Methods: The miRNA expression of HNSCC tissue and plasma EVs were profiled by small RNA sequencing. qRT-PCR was performed to detect miR-99a-5p expression in HNSCC (n = 93) and benign disease (n = 39) plasma EVs and formalin-fixed and paraffin-embedded (FFPE) tissue (n = 110). We constructed receiver-operating characteristic curves to investigate the diagnostic efficiency of plasma EVs miR-99a-5p.Results: Tumor tissue exhibited lower miR-99a-5p than para-tumor tissue. Patients with high miR-99a-5p expression exhibited significantly more p16 positive status. In contrast, HNSCC plasma EVs harbored more miR-99a-5p than the benign disease group. Plasma EVs miR-99a-5p distinguished HNSCC with area under the curve (AUC) of 0.7494 (95% CI: 0.6692–0.8296; p < 0.0001), with 61.54% sensitivity and 75.27% specificity, respectively. Furthermore, plasma EVs miR-99a-5p also distinguished early HNSCC with AUC of 0.7394 (95% CI: 0.6284–0.8504; p = 0.0002), with 79.07% sensitivity and 61.54% specificity, respectively.Conclusion: Plasma EVs miR-99a-5p is a potential biomarker for predicting early HNSCC.

show abstract

Section: Discussionmentioning

confidence: 99%

Plasma Extracellular Vesicles-Derived miR-99a-5p: A Potential Biomarker to Predict Early Head and Neck Squamous Cell Carcinoma

Huang

Shen

Hsueh

et al. 2022

Pathol. Oncol. Res.

View full text Add to dashboard Cite

show abstract

“…In another study, a model based on EV-miR-491-5p expression was developed as a prediction tool to discriminate between patients with HNSCC and healthy controls, showing a sensitivity and specificity of 46.6% and 100%, respectively. Furthermore, it was found that the dynamic change of miRNA-491-5p pre- vs. post-treatment was associated with the 1-year disease recurrence rate (80% sensitivity and 69.23% specificity), as well as disease free survival and overall survival (HR of 2.82 and 5.66, respectively) [ 123 ]. This finding might help identify HNSCC patients who are at high risk of tumor recurrence.…”

Section: Ev-mirnas In the Clinical Management Of Hnsccmentioning

confidence: 99%

More than a Bubble: Extracellular Vesicle microRNAs in Head and Neck Squamous Cell Carcinoma

Panvongsa

Pegtel

Voortman

2022

Cancers

Self Cite

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that play a pivotal regulatory role in a broad variety of biological processes. Dysregulation of miRNAs is associated with several human diseases, particularly cancer. Extracellular vesicles (EVs) are crucial components in intercellular communication. As part of the cargo of EVs, miRNAs are involved in EV-mediated cell-to-cell interactions, including promotion or suppression of tumor development. The knowledge on the molecular mechanisms and clinical importance of EV-miRNAs in head and neck squamous cell carcinoma (HNSCC) has rapidly grown over the past years. In the present review, the current understanding regarding the effect of EV-miRNAs on HNSCC tumorigenesis is summarized, which includes effects on tumor proliferation, angiogenesis, invasion and metastasis, the tumor microenvironment, immune modulation, and treatment resistance. EV-miRNA-based biomarkers in liquid biopsies such as blood and saliva may open up new possibilities for employing EV-miRNAs for screening and early diagnostics as well as disease monitoring. Future perspectives include the promise of EV-miRNAs as a novel therapeutic target.

show abstract

“…Momen-Heravi and Bala [ 100 ] identified circulating EVs from plasma of OSCC patients enriched with miR-21, miR-27b, and miR-27a. Panvongsa et al [ 101 ] observed that four miRNAs in plasma-derived EVs (miR-27b-3p, miR-491-5p, miR-1910-5p, and miR-630) were significantly dysregulated in locally advanced HNSCC compared with healthy donors, being ΔmiR-491-5p associated with OS and DFS. Salivary exosomal miRNAs have been investigated in OSCC patients, being found significant increase in miR-24-3p, miR-512-3p, and miR-412-3p levels in patients compared to controls [ 102 , 103 ].…”

Section: Evsmentioning

confidence: 99%

“…Liquid biopsy is a promising investigation area in the oncology field, being successfully described in translational studies [ 11 , 36 , 55 , 82 , 101 ]. Besides being a minimally invasive procedure, the major clinical interest in liquid biopsy is that molecular alterations detected in circulating biomarkers may reflect the alterations found in tumor tissues, thus reducing the number of invasive biopsies to monitor the tumor process.…”

Section: Challenges and Perspectivesmentioning

confidence: 99%

Clinical applications of liquid biopsy in HPV‐negative and HPV‐positive head and neck squamous cell carcinoma: advances and challenges

Chantre-Justino

Alves

Delmonico³

2022

Exploration of Targeted Anti-Tumor Therapy

View full text Add to dashboard Cite

Head and neck squamous cell carcinomas (HNSCCs) represent the most common epithelial tumors that arise from mucosa of the oral cavity, pharynx, and larynx. The development of HNSCCs is usually associated with tobacco use, alcohol consumption, and human papillomavirus (HPV) infection. Most HNSCCs are diagnosed in advanced states, leading to a worse clinical outcome. Screening tests based on potential biomarkers associated with HNSCCs could improve this scenario. Liquid biopsy has emerged as a promising area of cancer investigation, offering a minimally invasive approach to track circulating biomarkers in body fluids that could potentially contribute to the diagnosis, predict prognosis, and monitor response to treatment. This review will discuss translational studies describing the clinical applications of liquid biopsy in HPV‐negative and HPV‐positive HNSCCs focused on circulating nucleic acids [cell-free DNA (cfDNA) and cell-free RNA (cfRNA)], circulating tumor cells (CTCs), and extracellular vesicles (EVs), which can be found in plasma, serum, and saliva.

show abstract

Plasma extracellular vesicle microRNA‐491‐5p as diagnostic and prognostic marker for head and neck squamous cell carcinoma

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 20 publications

References 42 publications

Plasma Extracellular Vesicles-Derived miR-99a-5p: A Potential Biomarker to Predict Early Head and Neck Squamous Cell Carcinoma

Plasma Extracellular Vesicles-Derived miR-99a-5p: A Potential Biomarker to Predict Early Head and Neck Squamous Cell Carcinoma

More than a Bubble: Extracellular Vesicle microRNAs in Head and Neck Squamous Cell Carcinoma

Clinical applications of liquid biopsy in HPV‐negative and HPV‐positive head and neck squamous cell carcinoma: advances and challenges

Contact Info

Product

Resources

About