Plasma extracellular vesicles microRNA-208b-3p and microRNA-143-3p as novel biomarkers for sudden cardiac death prediction in acute coronary syndrome

Huang, Shuainan; Zhang, Jiahui; Wan, Hua; Wang, kang; Wu, Jiayi; Cao, Yue; Li, Hu; Yu, Yizhen; Sun, Hao; Yu, Youjia; Wang, Jie; Chen, Feng

doi:10.1039/d2mo00257d

Cited by 11 publications

(3 citation statements)

References 55 publications

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“…This study found that the main causes of death from circulatory diseases were sudden cardiac death, acute myocardial infarction and cerebral hemorrhage. Huang S et al [27] reported in the literature that the annual incidence of sudden cardiac death in China is about 41.84 per 100,000, which is the country with the highest incidence of sudden cardiac death in the world. injury-poisoning contribute to a signi cant disease burden in society, with Mulima G et al [28] reporting that more than ve million people die from injuries each year, accounting for 9% of all deaths worldwide.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and SARIMA model of death cases in a tertiary comprehensive hospital in Hangzhou from 2015 to 2022

Dai,

Xiao,

Sheng

et al. 2024

Preprint

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Background The statistical analysis of death cases has important clinical research value. Our study aims to describe the epidemiology of death cases in a tertiary comprehensive hospital in Hangzhou from 2015 to 2022 and predict the number of future deaths, providing a reference basis for hospitals to formulate relevant strategies and measures. Methods Death data of inpatients and non-inpatients in the hospital from 2015 to 2022 were obtained through the CDC-DSP system. The data of death cases were described and analyzed by retrospective study, and the single factor difference was statistically inferred by χ2 tests. P < 0.05 was considered statistically significant. According to International Classification of Diseases 10th revision (ICD-10), the main causes of death of patients were obtained. SARIMA model was established by R 4.3.0 (forecast, aTSA, tseries) software for time series analysis. Results A total of 1938 death cases from 2015 to 2022, including 287 inpatients and 1651 non- inpatients. Among them, the highest was in 2022 (262, 13.52%), and the lowest was in 2019 (223, 11.51%). The gender ratio is 2.22:1, and there are differences (P < 0.05) between different genders in the age, marital status, educational level, and distribution of place of residence. The main cause of death were circulatory system diseases (32.66%), injury-poisoning (28.22%), tumors (14.76%), and respiratory system diseases (10.47%), with a cumulative proportion of 86.12%. Furthermore, the SARIMA (2,1,1)(1,1,1)12 model was ultimately determined to predict the number of deaths among patients, AIC = 380.23, BIC = 392.79, AICc = 381.81, MAPE = 14.99%. Conclusions The hospital should focus on improving the pre-hospital emergency treatment and the ability of multi-disciplinary cooperation in the hospital to reduce the number of deaths of hospital patients. the SARIMA model is suitable for predicting the number of death cases and provide reference value for the rational allocation of medical resources.

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Section: Discussionmentioning

confidence: 99%

Epidemiology and SARIMA model of death cases in a tertiary comprehensive hospital in Hangzhou from 2015 to 2022

Dai,

Xiao,

Sheng

et al. 2024

Preprint

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“…Published role Reference miR-10a-5p Inhibits autoimmune T-cell responses [71] miR-19b-3p a) Increases innate immune response including TLR4 [72,73] miR-23b-3p Reduces cardiomyopathy by targeting/ reducing MyD88-induced NF𝜅B [74,75] miR-26a-5p Reduces fibrosis in lung, reduced in DCM patients and protects heart in animal model [76,77] miR-30a-5p Increased with CVB3 infection, protects against CVB3 myocarditis [78][79][80] miR-31-5p Targets CD40L and SAP to prevent activation of T helper cells [81] miR-99b-5p Inhibits NLRP3 inflammasome, inhibits PI3K/AKT/mTOR signaling [82,83] miR-125b-5p Associated with a number of cardiovascular diseases, but shown to inhibit IL-1𝛽 by targeting TRAF6/MAPK/NF𝜅B signaling [84][85][86][87] miR-143-3p Decreases TLR4, MyD88, and NF𝜅B and increases IL-10 [88] miR-145-5p Decreases TLR4 and PI3K/AKT/mTOR signaling [89,90] miR-148a-3p Inhibits IL-1𝛽 damaging effects and is inhibited by IL-1𝛽, inhibits NF-𝜅B during acute viral myocarditis [91,92] miR-148b-3p Increases proliferation of MSCs and Th2 responses that inhibit TLR4 [93,94] miR-152-3p Decreases PI3K/AKT signaling, inhibits mitochondrial autophagy [95,96] miR-186-5p Increases anti-viral beta-defensin-1 [97] miR-208b-3p Biomarker of sudden cardiac death, but fibroblasts treated with this miR when implanted in myocardial infarcts regenerated the heart and improved cardiac function [98,99] miR-339-5p Targets NEAT1 which regulates innate immune function [100,101] miR-345-5p Targets Drp1 and induces mitochondrial fission, decreases fibrosis by targeting HIF1a [77,102] miR-486-5p Increased with viral infections, but antiviral role…”

Section: Human Mirmentioning

confidence: 99%

Reconstituted Extracellular Vesicles from Human Platelets Decrease Viral Myocarditis in Mice

Beetler,

Bruno,

Watkins

et al. 2023

Small

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Patients with viral myocarditis are at risk of sudden death and may progress to dilated cardiomyopathy (DCM). Currently, no disease‐specific therapies exist to treat viral myocarditis. Here it is examined whether reconstituted, lyophilized extracellular vesicles (EVs) from platelets from healthy men and women reduce acute or chronic myocarditis in male mice. Human‐platelet‐derived EVs (PEV) do not cause toxicity, damage, or inflammation in naïve mice. PEV administered during the innate immune response significantly reduces myocarditis with fewer epidermal growth factor (EGF)‐like module‐containing mucin‐like hormone receptor‐like 1 (F4/80) macrophages, T cells (cluster of differentiation molecules 4 and 8, CD4 and CD8), and mast cells, and improved cardiac function. Innate immune mediators known to increase myocarditis are decreased by innate PEV treatment including Toll‐like receptor (TLR)4 and complement. PEV also significantly reduces perivascular fibrosis and remodeling including interleukin 1 beta (IL‐1β), transforming growth factor‐beta 1, matrix metalloproteinase, collagen genes, and mast cell degranulation. PEV given at days 7–9 after infection reduces myocarditis and improves cardiac function. MicroRNA (miR) sequencing reveals that PEV contains miRs that decrease viral replication, TLR4 signaling, and T‐cell activation. These data show that EVs from the platelets of healthy individuals can significantly reduce myocarditis and improve cardiac function.

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“…These molecules stand out for their high stability [17]-an important criterion in the search for clinical biomarkers. In fact, the analysis of different miRNAs has been investigated as an important tool in the diagnosis, treatment and understanding of cancer [18][19][20][21], neurological disorders [22][23][24] and cardiovascular diseases [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Identification of miR-30c-5p microRNA in Serum as a Candidate Biomarker to Diagnose Endometriosis

Chico-Sordo,

Ruiz-Martínez,

Toribio

et al. 2024

IJMS

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The diagnosis of endometriosis by laparoscopy is delayed until advanced stages. In recent years, microRNAs have emerged as novel biomarkers for different diseases. These molecules are small non-coding RNA sequences involved in the regulation of gene expression and can be detected in peripheral blood. Our aim was to identify candidate serum microRNAs associated with endometriosis and their role as minimally invasive biomarkers. Serum samples were obtained from 159 women, of whom 77 were diagnosed with endometriosis by laparoscopy and 82 were healthy women. First, a preliminary study identified 29 differentially expressed microRNAs between the two study groups. Next, nine of the differentially expressed microRNAs in the preliminary analysis were evaluated in a new cohort of 67 women with endometriosis and 72 healthy women. Upon validation by quantitative real-time PCR technique, the circulating level of miR-30c-5p was significantly higher in the endometriosis group compared with the healthy women group. The area under the curve value of miR-30c-5p was 0.8437, demonstrating its diagnostic potential even when serum samples registered an acceptable limit of hemolysis. Dysregulation of this microRNA was associated with molecular pathways related to cancer and neuronal processes. We concluded that miR-30c-5p is a potential minimally invasive biomarker of endometriosis, with higher expression in the group of women with endometriosis diagnosed by laparoscopy.

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Plasma extracellular vesicles microRNA-208b-3p and microRNA-143-3p as novel biomarkers for sudden cardiac death prediction in acute coronary syndrome

Abstract: Acute coronary syndrome (ACS) occurs as a result of myocardial ischemia that can give rise to a variety of acute cardiovascular events, including arrhythmia, heart failure and sudden cardiac death...

Cited by 11 publications

References 55 publications

Epidemiology and SARIMA model of death cases in a tertiary comprehensive hospital in Hangzhou from 2015 to 2022

Epidemiology and SARIMA model of death cases in a tertiary comprehensive hospital in Hangzhou from 2015 to 2022

Reconstituted Extracellular Vesicles from Human Platelets Decrease Viral Myocarditis in Mice

Identification of miR-30c-5p microRNA in Serum as a Candidate Biomarker to Diagnose Endometriosis

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