Plasma factor VII is activated by postprandial triglyceridaemia, irrespective of dietary fat composition

Postprandial lipid metabolism and thrombosis

“…They demonstrated that the postprandial increase in FVIIc was due entirely to activation of factor VII with a rise in FVIIa. This result was subsequently confirmed in a larger study (Bladbjerg et al 1994), and accorded with the findings of Miller et al (1991). Silveira et al (1994) followed the postprandial responses to a standard test meal (containing olive oil, 50 g/m2 body surface area) in thirty-three patients who had survived a myocardial infarction and ten healthy controls, the mean ages of both groups being 49 years.…”

“…Equally importantly, fasting FVIIc immediately before breakfast was found to be positively correlated with the amount of fat consumed during the previous 24 h ( r 0.52, P < 0-01), while the second study showed that this effect was discernible within 8 h of commencement of a fat-enriched diet (Table 2). Subsequent studies have demonstrated a postprandial elevation in FVIIc within 3 h of consumption of a fat-rich test meal (Miller et al 1991).…”

Geographic and Ethnic Differences in the Prevalence of Thrombophilia

“…Age, gender, BMI, insulin resistance and the use of oral contraceptives have been associated with FVII levels (Balleisen et al,1985). Dietary fats and blood lipids are important determinants of FVII levels (Miller et al,1991;Mennen et al,1996). Several studies have demonstrated that three polymorphisms of the FVII gene can directly influence the FVII levels and also modulate its response to environmental stimuli (Lane et al, 1992;Humphries et al, 1994;Hong et al, 1999) The Gln353 variant of the FVII gene has consistently been associated with lower levels of FVII in white Europeans (Humphries et al, 1994), Gujarati Indians (Lane et al, 1992), Afrocaribbean Britains (Lane et al, 1992;Temple et al, 1997) and Japanese (Kario et al, 1995).…”

Investigation of the association between the HindIII polymorphism of the LPL gene and the Taq1b polymorphism of the CETP gene with the risk of atherothrombotic stroke in the dwellers of Central Russia

“…В литературе имеются данные о том, что LPL акти-вирует фактор свертывания VII (FVII, проконвертин) че-рез собственный патогенетический путь [25]. Показано, что липолиз ЛПОНП, хиломикронов и содержащихся в них ТГ под действием LPL приводит к генерации отрица-тельного заряда на поверхности липопротеида, который активирует FVII [25][26]. Обнаруженная взаимосвязь между концентрацией ХС ЛПВП отражает активность LPL и базальный уровень активированного фактора свер-тывания FVIIа [27].…”