2021
DOI: 10.1016/j.numecd.2021.01.012
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Plasma fatty acids and kidney function decline in post-myocardial infarction patients of the Alpha Omega Cohort

Abstract: Background and aims: Age-related kidney function decline is accelerated in patients with coronary heart disease (CHD). CHD and chronic kidney disease may share common etiologies. We examined plasma fatty acids (FAs) as novel biomarkers of kidney function decline after myocardial infarction (MI). Methods and results: The analysis included 2329 Dutch posteMI patients aged 60-80y (Alpha Omega Cohort) most receiving state-of-the-art medications. Plasma FAs (% total FAs) in cholesteryl esters were assessed at basel… Show more

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Cited by 3 publications
(2 citation statements)
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“…These two studies were included in our pooled analysis with updated patient numbers and harmonised analytical protocols. 61 62 Our findings expand upon these previous individual cohort based analyses with a sevenfold larger sample size and enhanced statistical power to more precisely quantify the association of n-3 PUFAs with CKD. The large sample size also enabled a detailed evaluation of potential effect modifiers of the association between n-3 PUFAs and CKD.…”
Section: Discussionsupporting
confidence: 63%
See 1 more Smart Citation
“…These two studies were included in our pooled analysis with updated patient numbers and harmonised analytical protocols. 61 62 Our findings expand upon these previous individual cohort based analyses with a sevenfold larger sample size and enhanced statistical power to more precisely quantify the association of n-3 PUFAs with CKD. The large sample size also enabled a detailed evaluation of potential effect modifiers of the association between n-3 PUFAs and CKD.…”
Section: Discussionsupporting
confidence: 63%
“…Our literature search only identified two high quality prospective observational analyses of the association of n-3 PUFA biomarkers with incident CKD or decline in kidney. These two studies were included in our pooled analysis with updated patient numbers and harmonised analytical protocols 6162. Our findings expand upon these previous individual cohort based analyses with a sevenfold larger sample size and enhanced statistical power to more precisely quantify the association of n-3 PUFAs with CKD.…”
Section: Discussionmentioning
confidence: 54%