Plasma Fatty Acids in Pancreatic Cystic Fibrosis and Liver Disease

Caren, Raymond; Corbo, Lucille

doi:10.1210/jcem-26-4-470

Cited by 59 publications

(18 citation statements)

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“…The infant who has suffered from intrauterine malnutrition early in the third trimester of pregnancy is potentially at risk for continued growth retardation (I, 12), as well as learning and behavioral problems (2,13,28). These disorders appear to be more prominent among those children whose growth failure began before 26-34 weeksof gestation, in a pregnancy proceeding until near term (II, 16).…”

Section: Discussionmentioning

confidence: 99%

Abnormal Fatty Acid Turnover in the Phospholipids of the Red Blood Cell Membranes of Cystic Fibrosis Patients (in Vitro Study)

Rogiers¹,

Dab²,

Michotte³

et al. 1984

Pediatr Res

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ROGIERS ET AL.young DI rats than in young SO rats and adult DI and SO rats. We also found that this hypotension could be prevented by the continuous infusion of AVP (2000 pg·lOO g-I min-I). The adult 01 rats were more resistant to hemorrhagic hypotension than the infant 01 rats. The reason for this is not known. In addition to AVP, angiotensin has also been thought to prevent hemorrhagic hypotension. The angiotensin levels were the same in the adult DI and SO rats both during control conditions and following bleeding. It is therefore likely that the relative resistance to hemorrhagic hypotension, observed in adult DI rats, is independent of angiotensin.The serum AVP levels were measured in the SO rats. The capacity to release AVP was at least as good in young as in adult rats. Previous studies on fetal lambs have shown that the capacity to release AVP in response to blood volume contraction is well developed even in fetal life (12). The AVP levels recorded under basal conditions were high in both the adult and the infant 01 rats; they were 21 and 45 pg-ml", respectively. In adult rats that have been dehydrated for 48 h, the AVP concentration has been reported to be around 30 pg.ml-I (5). The SO rats in this study had been dehydrated for 10 h and subjected to anesthesia and blood vessel cannulation which might have caused the blood volume contraction. Great care had, however, been taken not to use animals that had been bled prior to carrying out the procedure. Following bleeding, the AVP levels increased in both groups, but the increase was significant only in the adult rats. It is possible, however, that the AVP levels in the infant rats were already so high during basal conditions that they represented maximal levels. SummaryA study was carried out in order to investigate whether the abnormal in vitro turnover of fatty acids in the phospholipids of the red blood cell membranes of cystic fibrosis patients is intrinsic to the membrane, or whether it is induced by extrinsic serum factors. Red blood cells of cystic fibrosis patients and healthy subjects were labeled in vitro with 1 14 q linoleic acid, bound to albumin. The labeled cells were reincubated in autologous and homologous serum. The radioactivity present in the serum lipids and in the major phospholipid fractions of the red cell membranes was measured.Conclusions of this study are: 1) not all of the cystic fibrosis patients examined individually show an abnormal in vitro turnover of the red cell fatty acids, although they all presented abnormal fatty acid patterns for the red blood cell phospholipids,

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Section: Discussionmentioning

confidence: 99%

Abnormal Fatty Acid Turnover in the Phospholipids of the Red Blood Cell Membranes of Cystic Fibrosis Patients (in Vitro Study)

Rogiers¹,

Dab²,

Michotte³

et al. 1984

Pediatr Res

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“…Among the metabolic abnormalities, EFAD has often been described in patients with CF [9,[23][24][25][26]. Over 40 years ago, the fatty acid composition of serum chylomicrons was investigated in children with CF in whom LA serum concentrations were found to be lowered by 58% when comparing with those obtained from normal children [23].…”

Section: Polyunsaturated Fatty Acid Status In Patients With Cystic Fimentioning

confidence: 99%

“…An overview is given in Tables 1-6 according to the nature of the lipid fraction used for performing analyses of PUFA in blood (Tables 1-5) or to the composition in phospholipids of erythrocyte membrane ( Table 6). The first studies on circulating fatty acid quantification have mainly focused on ω6 fatty acid content [23][24][25][26]28,29,[31][32][33][34]36,37,[39][40][41], while latter reports have additionally assessed ω3 fatty acids, notably DHA [27,30,35,38,[42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61].…”

Section: Polyunsaturated Fatty Acid Status In Patients With Cystic Fimentioning

confidence: 99%

“…Moreover, analytical techniques differ among the studies. Some authors used capillary gas chromatography [43,46,47,50,52,54,56,58,60,61], which has a much higher separating potential compared with the packed column gas chromatography used by others [23][24][25]27,28,32,38,41,42]. More recently, gas chromatography coupled with mass spectrometry has been used in high resolution studies [53,59].…”

Section: Polyunsaturated Fatty Acid Status In Patients With Cystic Fimentioning

confidence: 99%

“…The picture concerning the ω6 fatty acids seems quite unequivocal, since circulating levels of the precursor LA, and to some extent its metabolites, are found to be decreased in CF in most studies [23][24][25][26][27][28][30][31][32][33][34][35][36][37][38][39][40][41][42][44][45][46][47][49][50][51][52][53][54][55][56][57][58]60,61] irrespective of the lipid classes used to assess quantitative analyses. Moreover, the severity of alterations was occasionally related to the pancreatic status [24,27,30,31,34,[36][37][38][39]42,43,48,49,51,…”

Section: Polyunsaturated Fatty Acid Status In Patients With Cystic Fimentioning

confidence: 99%

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An overview of monitoring and supplementation of omega 3 fatty acids in cystic fibrosis

Coste

Armand

Lebacq

et al. 2007

Clinical Biochemistry

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Linoleic Acid Absorption from Lipid Supplements in Patients with Cystic Fibrosis with Pancreatic Insufficiency and in Control Subjects

McKenna,

Hubbard,

Bieri

1985

J. pediatr. gastroenterol. nutr.

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To determine the relative role of malabsorption as the cause of decreased linoleic acid in blood and tissue lipids of patients with cystic fibrosis (CF) and pancreatic insufficiency, the increase in plasma linoleic acid was determined after ingestion of various lipid supplements. CF patients with documented pancreatic insufficiency and normal control subjects were given each of four different lipid supplements on separate days (a minimum of 3 days apart). The supplements were commercial safflower oil, Microlipid, Captex 810D, and Captex 810B. Fasting subjects consumed 36 g of lipid in a milk shake containing 15 g of protein and 45 g of carbohydrate. Plasma samples obtained at 0, 2, 4, 6, and 8 h after the meal showed that CF patients absorbed linoleic acid from all of the lipid preparations tested when administered with their regular dose of pancreatic enzyme supplement. The mean maximal increase in percent plasma linoleic acid in CF patients was not different from controls after ingestion of safflower oil, Microlipid, and Captex 810B. With Captex 810D the CF patients had a significantly higher increase in percent plasma linoleic acid than controls, 6.75% vs. 2.27%, respectively, at 2 h (p < 0.01), and 11.10% vs. 4.65% at 8 h(p < 0.01). The CF patients also appeared to absorb the Captex products faster than controls, suggesting that presence of medium chain length fatty acids in these structured lipids facilitated their utilization by CF patients. The results indicate that malab‐sorption alone cannot account for the inadequate or marginal essential fatty acid status of CF patients. The fact that linoleic acid was absorbed as well by CF patients as controls in the present study suggests that CF patients in many previous supplementation studies either have not been given sufficient linoleic acid or have used the linoleic acid ingested to meet caloric needs. There is increasing evidence that adequate total caloric intake may be a far more important factor in determining the essential fatty acid status of CF patients than previously recognized. Our results suggest that long‐term consumption of supplemental linoleic acid in addition to adequate caloric intake should improve the linoleic acid status of most, if not all, CF patients.

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Plasma Fatty Acids in Pancreatic Cystic Fibrosis and Liver Disease

Cited by 59 publications

References 1 publication

Abnormal Fatty Acid Turnover in the Phospholipids of the Red Blood Cell Membranes of Cystic Fibrosis Patients (in Vitro Study)

Abnormal Fatty Acid Turnover in the Phospholipids of the Red Blood Cell Membranes of Cystic Fibrosis Patients (in Vitro Study)

An overview of monitoring and supplementation of omega 3 fatty acids in cystic fibrosis

Linoleic Acid Absorption from Lipid Supplements in Patients with Cystic Fibrosis with Pancreatic Insufficiency and in Control Subjects

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