Plasma Fibrinogen and C-reactive protein levels in Alzheimer’s disease and Mild cognitive impairment

Abstract

OBJECTIVES OBJECTIVESAlzheimer's disease (AD) is the most common form of dementia and is characterized clinically by a gradual decline in cognitive function, an increasingly neuropsychiatric and behavioral disturbances. Until recently, the treatment targeting neurodegenerative chain reaction has not shown clear results. And cholinesterase inhibitors have improved some cognitive function, it was not a satisfactory result. In this situation, studies have shown that inflammation of the brain can be the cause of AD. The aim of this study was to measure and compare the levels of CRP and fibrinogen in patients with AD, Mild cognitive impairment (MCI), normal control (NC) groups and to investigate the correlations between blood-based inflammatory factors and cognitive functions.