Plasma fibrinogen and serum C-reactive protein are associated with non-small cell lung cancer

Jones, J. B.; McGonigle, Niall; McAnespie, Martin; Cran, G. W.; Graham, Alastair

doi:10.1016/j.lungcan.2006.03.012

Cited by 97 publications

(110 citation statements)

References 27 publications

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“…A state of chronic inflammatory reaction and hypercoagulability in patients with malignant tumor increases plasma fibrinogen concentration [13]. Elevated plasma fibrinogen concentration has been associated with progression of many malignant tumors, including endometrial cancer, ovarian cancer, cervical cancer, gastric cancer, pancreatic cancer, colorectal cancer, lung cancer, esophagus cancer and HCC [14][15][16][17][18][19][20][21][22][23][24]. In comparison to normal tissues, cancer tissues of HCC patients express higher mRNA encoding γ chain of fibrinogen, and elevated plasma fibrinogen concentration has been correlated with tumor thrombosis [25].…”

Section: Discussionmentioning

confidence: 99%

Preoperative Alfa-Fetoprotein and Fibrinogen Predict Hepatocellular Carcinoma Recurrence After Liver Transplantation Regardless of the Milan Criteria: Model Development with External Validation

Jiang

Zeng

Dou

et al. 2018

Cell Physiol Biochem

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Background/Aims: Patient selection is critically important in improving the outcomes of liver transplantation for hepatocellular carcinoma. The aim of the current study was to identify biochemical measures that could affect patient prognosis after liver transplantation. Methods: A total of 119 patients receiving liver transplantation for hepatocellular carcinoma were used to construct a model for predicting recurrence. The results were validated using an independent sample of 109 patients from independent hospitals. All subjects in both cohorts met the Hangzhou criteria. Results: Analysis of the discovery cohort revealed an association of recurrence with preoperative fibrinogen and AFP levels. A mathematical model was developed for predicting probability of recurrence within 5 years: Y = logit(P) = -4.595 + 0.824 ×fibrinogen concentration (g/L) + 0.641 × AFP score (1 for AFP<=20ng/ml, 2 for 20 400ng/ml). At a cutoff score of -0.85, the area under the curve (AUC) was 0.819 in predicting recurrence (vs. 0.655 when using the Milan criteria). In the validation cohort, this model had reasonable performance in predicting 5-year overall survival (68.8% vs. 28.1% in using the -0.85 cutoff, p< 0.001) and disease-free survival (65.7% vs. 25.9%, p< 0.001). The sensitivity and specificity were 77.0% and 62.5%, respectively. The AUC of this newly developed model was similar to that with the Milan criteria (0.698 vs. 0.678). Surprisingly, the DFS in patients with score <= -0.85 under this model but not meeting the Milan criteria was similar to that in patients meeting the Milan criteria (53.8% vs. 60.0%, p=0.380). Conclusions: Preoperative AFP and fibrinogen are useful in predicting recurrence of hepatocellular carcinoma after liver transplantation.

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Section: Discussionmentioning

confidence: 99%

Preoperative Alfa-Fetoprotein and Fibrinogen Predict Hepatocellular Carcinoma Recurrence After Liver Transplantation Regardless of the Milan Criteria: Model Development with External Validation

Jiang

Zeng

Dou

et al. 2018

Cell Physiol Biochem

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“…Interestingly, several studies have demonstrated the association between elevated levels of Wbrinogen gamma chain and worse outcome in diVerent tumors (Jones et al 2006;Guo et al 2009;Polterauer et al 2009;Sahni et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Changes in the expression of plasma proteins associated with thrombosis in BRCA1 mutation carriers

Custodio

López‐Farré

Zamorano-León

et al. 2012

J Cancer Res Clin Oncol

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“…Recent studies have indicated that elevated plasma fibrinogen levels are associated with tumor progression and other poor outcomes in several types of malignancies, including esophageal cancer [6], gastric cancer [7], pancreatic cancer [8], colon cancer [9], lung cancer [10], and gynecological cancer [11,12,13]. …”

Section: Introductionmentioning

confidence: 99%

Elevated Plasma Fibrinogen Levels Are Associated with a Poor Prognosis in Patients with Hepatocellular Carcinoma

Kinoshita¹,

Onoda²,

Imai³

et al. 2013

Oncology

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Objectives: Elevated plasma fibrinogen levels are associated with tumor progression and poor outcomes in cancer patients. We investigated the prognostic value of pretreatment plasma fibrinogen levels in patients with hepatocellular carcinoma (HCC). Methods: One hundred and thirteen patients with newly diagnosed HCC were retrospectively evaluated. We investigated the correlation between pretreatment plasma fibrinogen levels, clinicopathological parameters and overall survival. Both univariate and multivariate analyses were performed to identify the clinicopathological parameters associated with overall survival. Results: The median value of the pretreatment plasma fibrinogen level was 279 mg/dl. Elevated plasma fibrinogen levels were associated with larger tumor size, the presence of vascular invasion and higher Cancer Liver Italian Program scores. Lower plasma fibrinogen levels were associated with higher Child-Pugh grades. The overall survival rates in patients with pretreatment plasma fibrinogen levels ≥315 mg/dl were significantly lower than those with a pretreatment plasma fibrinogen level <315 mg/dl (p = 0.016). On multivariate analysis, the plasma fibrinogen levels (per 100 mg/dl) were found to be independently associated with overall survival (hazard ratio 1.236; p = 0.046). Conclusions: This study demonstrates that elevated pretreatment plasma fibrinogen levels are associated with tumor progression and are independently associated with a poor prognosis in patients with HCC.

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Plasma fibrinogen and serum C-reactive protein are associated with non-small cell lung cancer

Cited by 97 publications

References 27 publications

Preoperative Alfa-Fetoprotein and Fibrinogen Predict Hepatocellular Carcinoma Recurrence After Liver Transplantation Regardless of the Milan Criteria: Model Development with External Validation

Preoperative Alfa-Fetoprotein and Fibrinogen Predict Hepatocellular Carcinoma Recurrence After Liver Transplantation Regardless of the Milan Criteria: Model Development with External Validation

Changes in the expression of plasma proteins associated with thrombosis in BRCA1 mutation carriers

Elevated Plasma Fibrinogen Levels Are Associated with a Poor Prognosis in Patients with Hepatocellular Carcinoma

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