Plasma fibrinogen level and long‐term prognosis in Norwegian middle‐aged patients with previous myocardial infarction. A 10 year follow‐up study

Retterstøl, Lars; Kierulf, Peter; Pedersen, Jan; Bøhn, M.; Bakken, A.; Erikssen, Jan; Berg, Kåre

doi:10.1046/j.1365-2796.2001.00837.x

Cited by 11 publications

(10 citation statements)

References 23 publications

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“…In addition, those in the top quartile of fibrinogen levels have a 2 times greater risk of cardiac death. 15,16 D-Dimer was found in our study to be similarly predictive for primary cardiac events in both hypertensive and nonhypertensive patients after infarction. This observation indicates that an enhanced thrombogenic activity contributes to cardiac events in both groups of patients.…”

Section: Discussionsupporting

confidence: 67%

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History of Hypertension and Enhanced Thrombogenic Activity in Postinfarction Patients

et al. 2003

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Abstract-Hypertension is a risk factor for coronary thrombosis and death in cardiac patients mediated in part by endothelial damage or dysfunction and increased thrombogenicity. However, there are no data regarding the association between hypertension and thrombogenic activity in stable patients after myocardial infarction and limited data about the prognostic significance of thrombogenic factors in hypertensive patients after infarction. Therefore, levels of thrombogenic, lipid, and inflammatory factors were measured 2 months after an acute myocardial infarction in 461 hypertensive and 582 nonhypertensive patients.

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Section: Discussionsupporting

confidence: 67%

“…13,[15][16][17][18][19] However, fibrinogen failed to enter our final predictive model. This could be because the levels of fibrinogen in our patients were not as high as in other studies in which there was a significant association with cardiac events.…”

Section: Discussionmentioning

confidence: 93%

History of Hypertension and Enhanced Thrombogenic Activity in Postinfarction Patients

et al. 2003

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“…Studies of patients with MI or unstable heart disease have reported associations between various inflammatory markers, eg, fibrinogen, CRP, serum amyloid A, interleukin-6, and an adverse prognosis. [7][8][9][10] Inflammation in unstable coronary plaque and the effects of the myocardial ischemia on the degree of inflammation could contribute to these relationships. Elevated ISPs, measured many years before the coronary events, were associated with a higher proportion of CHD deaths in the present study.…”

Section: Engström Et Al Isps and Fatality After Future Coronary Eventmentioning

confidence: 99%

“…[7][8][9][10] However, as many CHD deaths occur outside hospital, the inclusion of out-of-hospital deaths is an important prerequisite for a representative study of survival after acute coronary events. 1 Previous studies from the population-based cohort "Malmö Preventive Study" have shown that the incidence of MI and stroke is increased in men with elevated plasma levels of fibrinogen, orosomucoid (␣ 1 -acid glucoprotein), ␣ 1 -antitrypsin, haptoglobin, or ceruloplasmin, ie, 5 ISPs.…”

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confidence: 99%

Fatality of Future Coronary Events Is Related to Inflammation-Sensitive Plasma Proteins

et al. 2004

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Background-Approximately 40% of men suffering a first acute coronary event die the first day; most of them never reach hospital. It is largely unknown whether a low-grade inflammation in healthy men predicts the fatality of future coronary events. Methods and Results-Five inflammation-sensitive plasma proteins (ISPs; fibrinogen, orosomucoid, ␣ 1 -antitrypsin, haptoglobin, and ceruloplasmin) were measured in 6075 apparently healthy men, 680 of whom had a first coronary event [nonfatal myocardial infarction (MI) or death from coronary heart disease (CHD)] over a mean follow-up of 19 years. Of the 680 men who had a coronary event, 197 died the first day and 228 died within 28 days. Elevated ISPs were significantly associated with both nonfatal MI and CHD death, but the relative risks for CHD death were higher than for nonfatal MI. Among men who subsequently had a coronary event, the proportion of fatal events was related to the number of elevated ISPs at the baseline examination. The proportions who died the first day were 26%, 25%, 29%, and 35%, respectively, among men with 0, 1, 2, and Ն3 elevated ISPs (trend: Pϭ0.01, adjusted for risk factors). The corresponding proportions who died within 28 days were 30%, 31%, 34%, and 38%, respectively (trend: Pϭ0.03). Conclusions-Men who have been exposed to a low-grade inflammation many years earlier have higher fatality in future coronary events, with a higher proportion of CHD deaths and less nonfatal MI. This relation should be regarded when inflammatory markers are considered for risk assessment in primary prevention.

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“…The association found between a high fibrinogen level and an increased risk of mortality confirms results from previous studies. Increased fibrinogen levels have been found to be a risk factor for CAD [47] and have also been shown to be a predictor of cardiac death in patients with previous AMI [48]. A high SR was also associated with an increased hazard ratio in the univariate analysis.…”

Section: Discussionmentioning

confidence: 99%

Is lipoprotein(a) a predictor for survival in patients with established coronary artery disease? Results from a prospective patient cohort study in northern Sweden

Glader

Birgander

Stenlund

et al. 2002

Journal of Internal Medicine

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. Ahlbeck Glader C, Slunga Birgander L, Stenlund H, Dahlén GH (Umeå University, Umeå, Sweden). Is lipoprotein(a) a predictor for survival in patients with established coronary artery disease? Results from a prospective patient cohort study in northern Sweden. J Intern Med 2002; 252: 27–35. Objectives. Lipoprotein(a) [Lp(a)] is a known risk factor for the development of atherosclerosis. The aim of the present study was to test the importance of Lp(a) as a predictor for the further prognosis in patients with established coronary artery disease. Design. A prospective patient cohort study was carried out. Setting and subjects. The cohort consists of 1216 patients who were examined with coronary angiography at the University Hospital in Umeå, Sweden, because of stable effort angina. Main outcome measures. Lipids, Lp(a), fibrinogen, antithrombin III (AT III), sedimentation rate and clinical data were registered at angiography. After a mean follow‐up time of 6.7 years information on survival was collected from the municipal census lists and death certificates were examined. Total mortality and mortality because of cardiovascular disease were both used as outcome variables in the survival analyses. Results. The total mortality in the patient cohort was 16.4%. An Lp(a) level of 300 mg L−1 or more was found in 30% of the study population and was found to be an independent predictor for death. A high fibrinogen, a low AT III level, a depressed left ventricular function and a high coronary obstruction score were other significant independent predictors of death. Total cholesterol, HDL‐ and LDL‐cholesterol were not related to survival in this study, but a substantial proportion of the population probably received lipid‐lowering agents during the study period. Conclusions. An Lp(a) level exceeding 300 mg L−1 indicates a poor further prognosis and may help to identify patients who probably need powerful secondary prevention programmes to improve their prognosis.

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Plasma fibrinogen level and long‐term prognosis in Norwegian middle‐aged patients with previous myocardial infarction. A 10 year follow‐up study

Cited by 11 publications

References 23 publications

History of Hypertension and Enhanced Thrombogenic Activity in Postinfarction Patients

History of Hypertension and Enhanced Thrombogenic Activity in Postinfarction Patients

Fatality of Future Coronary Events Is Related to Inflammation-Sensitive Plasma Proteins

Is lipoprotein(a) a predictor for survival in patients with established coronary artery disease? Results from a prospective patient cohort study in northern Sweden

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