Plasma Fibronectin Concentration in Obese/Overweight Pregnant Women: A Possible Risk Factor for Preeclampsia

Abstract

Plasma fibronectin (FN) levels in obese/overweight and non-obese pregnant women were evaluated as a possible risk factor for preeclampsia. A total of one hundred and sixty three pregnant women attending antenatal clinic at University of Calabar Teaching Hospital participated in the study and sixty non-pregnant women served as control. About 77 (47.24%) of the pregnant women were followed up for any subsequent development of preeclampsia during the pregnancy. Fibronectin levels in plasma were measured by ELISA assay and serum total protein, urea and creatinine were determined spectrophotometrically. The mean plasma FN concentration of nonobese pregnant women in first trimester was lower than those of the non-pregnant women by 24%, but however, increased to the non-pregnant level in second and third trimesters. Obese/overweight pregnant women had significantly (P \ 0.05) higher values than non-obese pregnant women in second and third trimesters. FN in obese/overweight pregnant women correlated positively with mean arterial blood pressure (MAP: r = 0.414, P = 0.04). About 28.57% of the pregnant women with FN above cut off point of 330 lg/ml at 18-24 weeks of gestation developed preeclampsia. This value increased to 40.0% when only the obese/overweight women were considered. On analysis of both fibronectin[330 lg/ml and MAP [ 90, the predictive value increased to 66.7%. We therefore conclude that elevated FN may be regarded as a risk factor of preeclampsia especially among the obese women.

Characterization of plasma fibronectin for migration, proliferation, and differentiation on human articular chondrocytes

“…Plasma FN as an initial factor plays a crucial role in wound healing because it binds to fibrinogen and induces cell migration mostly via its interaction with integrin α 5 β 1 (Lenselink, ). Our analysis of human serum showed a pFN concentration of approximately 315 μg/ml in a donor pool, which is in line with reported concentrations of 220–380 μg/ml for healthy donors (Ekaidem, Bolarin, Udoh, Etuk, & Udiong, ; Fucikova, et al, ; Telci et al, ).…”

Effects of Caloric Restriction with Protein Supplementation on Plasma Protein Profiles in Middle-Aged Women with Metabolic Syndrome—A Preliminary Open Study

“…Furthermore, the adipose tissue gene expression of FINC was significantly downregulated in those who successfully maintained their weight after the CR intervention and the following weight maintenance phase [40]. Studies have suggested that increased FINC plasma levels are related to DM, cardiovascular disease, kidney disease, and pre-eclampsia [41,42,43,44,45,46]; therefore, the significant decrease in FINC plasma levels throughout the interventions in both groups suggests that CRPS is beneficial in metabolic abnormalities.…”

Identification of Early-Onset Preeclampsia-Related Genes and MicroRNAs by Bioinformatics Approaches

“…39,40 What is more, FN1 is regarded as a risk factor of EOPET especially among the fubsy women. 41 In consequence, FN1 may be also considered as a biomarker of EOPET.…”