Plasma folate levels and associated factors in women planning to become pregnant in a population with high prevalence of neural tube defects

Ma, Rui; Wang, Linlin; Jin, Lei; Li, Zhiwen; Ren, Aiguo

doi:10.1002/bdr2.1040

Cited by 10 publications

(7 citation statements)

References 50 publications

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“…Of particular importance, the findings that mean PF differed significantly between ethnic groups (with a significantly lower PF level observed in Pacific participants) warrants further exploration. A higher BMI category was also significantly negatively associated with PF in the present study, in contrast with the findings by Liu et al (45) and Ma et al (57) . This difference is probably due to the use of only two categories of BMI in their analyses (normal BMI v. overweight), whereas the present study also included a third (BMI >30 kg/m 2 (obese)) category.…”

Section: Discussioncontrasting

confidence: 99%

Plasma folate and its association with folic acid supplementation, socio-demographic and lifestyle factors among New Zealand pregnant women

et al. 2019

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Folic acid (FA) supplementation is recommended in the periconceptional period, for the prevention of neural tube defects. Limited data are available on the folate status of New Zealand (NZ) pregnant women and its association with FA supplementation intake. Objectives were to examine the relationship between plasma folate (PF) and reported FA supplement use at 15 weeks’ gestation and to explore socio-demographic and lifestyle factors associated with PF. We used data and blood samples from NZ participants of the Screening for Pregnancy Endpoints cohort study. Healthy nulliparous women with singleton pregnancy (n 1921) were interviewed and blood samples collected. PF was analysed via microbiological assay. Of the participants, 73 % reported taking an FA supplement at 15 weeks’ gestation – of these, 79 % were taking FA as part of/alongside a multivitamin supplement. Of FA supplement users, 56 % reported consuming a daily dose of ≥800 μg; 39 % reported taking less than 400 µg/d. Mean PF was significantly higher in women reporting FA supplementation (54·6 (se 1·5) nmol/l) v. no FA supplementation (35·1 (se 1·6) nmol/l) (P<0·0001). Reported daily FA supplement dose and PF were significantly positively correlated (r 0·41; P<0·05). Younger maternal age, Pacific and Maori ethnicity and obesity were negatively associated with PF levels; vegetarianism was positively associated with PF. Reported FA supplement dose was significantly associated with PF after adjustment for socio-demographic, lifestyle confounders and multivitamin intake. The relationship observed between FA supplementation and PF demonstrates that self-reported intake is a reliable proxy for FA supplement use in this study population.

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Section: Discussioncontrasting

confidence: 99%

Plasma folate and its association with folic acid supplementation, socio-demographic and lifestyle factors among New Zealand pregnant women

et al. 2019

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“…The results were consistent with the previous studies [24,43,44]. Because the prevalence (19%) of 677TT genotype is high in China, the risk of exposure to plasma folate deficiency, resultant hyperhomocysteinemia, and adverse pregnancy outcome may elevate [45][46][47].…”

Section: Discussionsupporting

confidence: 92%

“…Besides, Chinese government recommends all of the childbearing age women consuming 0.4 mg folic acid daily, and the rate of NTDs has shown a declining trend [54][55][56]. However, compared with US women's plasma folate level, our data indicated that the plasma folate level was lower than the geometric mean 37.3 nmol/L [46,57]. In conclusion, as many pregnancies are unplanned, and taking the MTHFR C677T and MTRR A66G polymorphisms and environmental factors into account, we recommend that health providers supply appropriate folic acid with or without multiple vitamin supplements to all childbearing age women based on their genotypes and vitamin status.…”

Section: Discussionmentioning

confidence: 51%

Association between Decreased Plasma Folate Levels and MTHFR C677T, and MTRR A66G Gene Polymorphisms as Determinants for Elevated Total Homocysteine Concentrations in Pregnant Women

Song¹,

Song²,

Bao³

et al. 2018

Hereditary Genet Curr Res

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Aims: The aims of this paper were to examine the association between gene polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G with levels of plasma folate and tHcy. Methods:Peripheral venous blood samples were obtained from 143 pregnant women, who had been fasted for more than 10 hours. Plasma tHcy and folate concentrations were measured in plasma specimens. The genotypes for polymorphisms were identified by the PCR-restriction fragment length polymorphism (RFLP). Results:Our results demonstrated that MTHFR 677T allele was the predictors of plasma folate levels in pregnant women. While MTHFR 677TT genotype and MTRR 66G allele were the predictors of plasma tHcy concentrations. Plasma folate levels were negatively correlated with tHcy concentrations (Pearson's correlation coefficient r=-0.358, p=0.000012). With the increase of gestational weeks, the levels of plasma folate was first risen and then fall, whereas, there was a downtrend between gestational weeks and tHcy levels. Conclusion:Plasma folate status and total homocysteine level associated with MTHFR C677T and MTRR A66G gene polymorphisms in pregnant women. According to our study, the pregnant women of homozygous mutation of MTHFR 677TT and/or MTRR 66GG genes generally have lower levels of folate. Therefore, we recommend that pregnant women with 677TT and 66GG genotypes should supplement the appropriate dosage of folic acid based on their genotypes.

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“…None of the folate replete women recruited in the present study were taking folic acid supplements preconceptionally. On the contrary, a study on women from Northern China revealed that 50% of them who planned to become pregnant had very low plasma folate levels (Ma, Wang, Jin, Li, & Ren, ). A study on Korean women reported only 26.4% preconceptional use of folic acid (Kim et al, ).…”

Section: Discussionmentioning

confidence: 99%

Trends of folate, vitamin B₁₂, and homocysteine levels in different trimesters of pregnancy and pregnancy outcomes

Mishra

Tomar

Puri

et al. 2020

American J Hum Biol

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Objective: To evaluate the effect of folate and vitamin B 12 levels on pregnancy progression and outcomes. Methods: The present study is a prospective follow up study of 100 pregnant women. Biochemical investigations (plasma homocysteine, folate, and vitamin B 12 levels) were performed on all pregnant women in first, second, and third trimesters. Nonparametric tests were used to compare the differences in median levels and odds ratio analysis for the assessment of the risk between the selected biomarkers and adverse pregnancy progression and outcomes. Results: The pregnant women at their first antenatal care visit were found to be predominantly folate replete (97%) and vitamin B 12 deficient (60%). Hyperhomocysteinemia in first and second trimesters was found to pose more than 3-fold increased risk for adverse pregnancy outcomes (P = .006 and .0002, respectively). Low birth weight (LBW) was found to be the most common adverse pregnancy outcome (52%), and was significantly associated with vitamin B 12 deficiency in the first and second trimesters (82%, P < .0001; 71.4%, P = .04, respectively). Conclusion: The vitamin B 12 deficiency is more common among Indian pregnant women as compared to folate deficiency. Hyperhomocysteinemia is an independent risk factor for pregnancy complications. Vitamin B 12 deficiency in first and second trimesters is associated with LBW babies.

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Plasma folate levels and associated factors in women planning to become pregnant in a population with high prevalence of neural tube defects

Cited by 10 publications

References 50 publications

Plasma folate and its association with folic acid supplementation, socio-demographic and lifestyle factors among New Zealand pregnant women

Plasma folate and its association with folic acid supplementation, socio-demographic and lifestyle factors among New Zealand pregnant women

Association between Decreased Plasma Folate Levels and MTHFR C677T, and MTRR A66G Gene Polymorphisms as Determinants for Elevated Total Homocysteine Concentrations in Pregnant Women

Trends of folate, vitamin B₁₂, and homocysteine levels in different trimesters of pregnancy and pregnancy outcomes

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Plasma folate levels and associated factors in women planning to become pregnant in a population with high prevalence of neural tube defects

Cited by 10 publications

References 50 publications

Plasma folate and its association with folic acid supplementation, socio-demographic and lifestyle factors among New Zealand pregnant women

Plasma folate and its association with folic acid supplementation, socio-demographic and lifestyle factors among New Zealand pregnant women

Association between Decreased Plasma Folate Levels and MTHFR C677T, and MTRR A66G Gene Polymorphisms as Determinants for Elevated Total Homocysteine Concentrations in Pregnant Women

Trends of folate, vitamin B12, and homocysteine levels in different trimesters of pregnancy and pregnancy outcomes

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Trends of folate, vitamin B₁₂, and homocysteine levels in different trimesters of pregnancy and pregnancy outcomes