Plasma for biomedical decontamination: from plasma-engineered to plasma-active antimicrobial surfaces

Ma, Chuanlong; Nikiforov, Anton; Morent, Rino; Ostrikov, Kostya Ken

doi:10.1016/j.coche.2021.100764

Cited by 27 publications

(14 citation statements)

References 57 publications

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“…At the same time, it will have a chemical reaction to produce ozone, nitrogen dioxide, nitric oxide, etc., accompanied by high-frequency pulse current and objective energy loss. In the application of corona discharge in the customization of materials, it can be seen that plasma-generated short-lived reactive oxygen and nitrogen species (RONS) are believed to be key agents for the variety of microorganisms [20].…”

Section: Discussionmentioning

confidence: 99%

Mutation of Bacillus velezensis Using Corona Discharge

Ranran

BenHui

Hu³

et al. 2022

Agronomy

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Bacillus velezensis is a kind of beneficial bacteria that is widely used in agriculture industry. Bacillus velezensis was irradiated with corona discharge generated by a needle-array high-voltage electrode. The results showed an improvement of activity of Bacillus velezensis by the corona discharge treatment was confirmed at an optimum input energy. Mutation of the Bacillus velezensis by the corona discharge treatment was also confirmed through an rRNA sequence alignment analysis. The enzyme activity of the mutated bacteria was greatly improved, which was a positive effect that can meet the production demand.

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Section: Discussionmentioning

confidence: 99%

Mutation of Bacillus velezensis Using Corona Discharge

Ranran

BenHui

Hu³

et al. 2022

Agronomy

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“…The products generated from the precursor-plasma reactions, such as reactive plasma species, as well as non-reactive species, deposit on the substrate, where the adsorption and surface reactions take place simultaneously. Some of the published results have been reviewed here [ 34 , 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Atmospheric Pressure Plasma Polymerisation of D-Limonene and Its Antimicrobial Activity

et al. 2023

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Antibacterial coating is necessary to prevent biofilm-forming bacteria from colonising medical tools causing infection and sepsis in patients. The recent coating strategies such as immobilisation of antimicrobial materials and low-pressure plasma polymerisation may require multiple processing steps involving a high-vacuum system and time-consuming process. Some of those have limited efficacy and durability. Here, we report a rapid and one-step atmospheric pressure plasma polymerisation (APPP) of D-limonene to produce nano-thin films with hydrophobic-like properties for antibacterial applications. The influence of plasma polymerisation time on the thickness, surface characteristic, and chemical composition of the plasma-polymerised films was systematically investigated. Results showed that the nano-thin films deposited at 1 min on glass substrate are optically transparent and homogenous, with a thickness of 44.3 ± 4.8 nm, a smooth surface with an average roughness of 0.23 ± 0.02 nm. For its antimicrobial activity, the biofilm assay evaluation revealed a significant 94% decrease in the number of Escherichia coli (E. coli) compared to the control sample. More importantly, the resultant nano-thin films exhibited a potent bactericidal effect that can distort and rupture the membrane of the treated bacteria. These findings provide important insights into the development of bacteria-resistant and biocompatible coatings on the arbitrary substrate in a straightforward and cost-effective route at atmospheric pressure.

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“…Similar findings were made for the portion of electric fields to the effects observed. Many studies have revealed and summarized the antimicrobial effects of gas plasma-derived ROS [ 17 , 18 ]. This was found mainly by adding antioxidant molecules or enzymes, such as N-acetylcysteine and catalase, to the samples, finding that many of the gas plasma-derived effects were reversed.…”

Section: Introductionmentioning

confidence: 99%

Argon Humidification Exacerbates Antimicrobial and Anti-MRSA kINPen Plasma Activity

Clemen

Singer

Skowski

et al. 2023

Life

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Gas plasma is a medical technology with antimicrobial properties. Its main mode of action is oxidative damage via reactive species production. The clinical efficacy of gas plasma-reduced bacterial burden has been shown to be hampered in some cases. Since the reactive species profile produced by gas plasma jets, such as the kINPen used in this study, are thought to determine antimicrobial efficacy, we screened an array of feed gas settings in different types of bacteria. Antimicrobial analysis was performed by single-cell analysis using flow cytometry. We identified humidified feed gas to mediate significantly greater toxicity compared to dry argon and many other gas plasma conditions. The results were confirmed by inhibition zone analysis on gas-plasma-treated microbial lawns grown on agar plates. Our results may have vital implications for clinical wound management and potentially enhance antimicrobial efficacy of medical gas plasma therapy in patient treatment.

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Plasma for biomedical decontamination: from plasma-engineered to plasma-active antimicrobial surfaces

Cited by 27 publications

References 57 publications

Mutation of Bacillus velezensis Using Corona Discharge

Mutation of Bacillus velezensis Using Corona Discharge

Atmospheric Pressure Plasma Polymerisation of D-Limonene and Its Antimicrobial Activity

Argon Humidification Exacerbates Antimicrobial and Anti-MRSA kINPen Plasma Activity

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