Plasma gastrin and gastric enterochromaffinlike cell activation and proliferation

Larsson, Håkan; Carlsson, Enar; Mattsson, Hillevi; Lundell, Lars; Sundler, F.; Sundell, Gunhild; Wallmark, Björn; Watanabe, Takehiko; Håkanson, R.

doi:10.1016/0016-5085(86)90938-8

Cited by 476 publications

(52 citation statements)

References 9 publications

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“…The complete suppression of acid secretion by omeprazole treatment induces elevated plasma gastrin levels (LARSSON et al, 1986). In the present study, plasma gastrin levels increased in both groups of rats treated with omeprazole for 14 and 35 days, indicating that acid secretion from parietal cells was inhibited in both experimental groups.…”

Section: Discussionsupporting

confidence: 57%

Changes in Subcellular Structures of Parietal Cells in the Rat Gastric Gland after Omeprazole.

Furuhashi¹,

Nakahara²,

Fukutomi³

et al. 1992

Archives of Histology and Cytology

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Summary. Omeprazole, an inhibitor of gastric acid secretion, was administered to rats at a dosage of 20 mg/kg/day for 14 and 35 days, and subsequent changes in subcellular structures of parietal cells were analyzed using morphometry and immunocytochemistry. Plasma gastrin levels were also examined, showing two times higher levels in the experimental groups than in the non-treated control. The volume and surface densities significantly decreased in tubulovesicles of the cells in the experimental rats. In the long term treatment of omeprazole (35 days), the volume density of microvilli on the membranes of secretory canaliculi in the cells also decreased significantly, whereas that of lysosomes clearly increased. By electron microscopy, many dense bodies of various shapes often appeared in the cytoplasm of parietal cells after the omeprazole treatment. Immunocytochemistry revealed that large granular immunodeposits for cathepsin B increase in the epithelial cells of the gastric glands after omeprazole treatment. These results suggest that omeprazole induces quantitatively significant decreases in both tubulovesicles and canalicular microvilli. The decreases in these membrane structures may possibly be ascribed to the degradation of the membrane in lysosomes; the proton pump on the membranes bound irreversibly with omeprazole is believed destined to be degraded in lysosomes.

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Section: Discussionsupporting

confidence: 57%

Changes in Subcellular Structures of Parietal Cells in the Rat Gastric Gland after Omeprazole.

Furuhashi¹,

Nakahara²,

Fukutomi³

et al. 1992

Archives of Histology and Cytology

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“…It may be relevant that the ECL cell tumours observed after a lifetime of dosing with omeprazole were much more common in female rats (Blom, 1986;Larsson et al, 1986)-a trend that was not observed with studies of clofibrate-like compounds in the rat (Eason et al, 1988c). The values of intragastric acidity before dosing in these 12 females are lower than similar measurements in healthy young men, and the plasma gastrin concentration appears to be relatively (but appropriately) Time ( higher.…”

Section: Discussionmentioning

confidence: 89%

“…Gastrin acts as a growth factor for gastric ECL cells (Larsson et al, 1986). Drugs which have an anti-secretory action in the stomach raise the plasma gastrin concentration, and in turn they may induce ECL cell hyperplasia and gastric carcinoids (Arnold et al, 1986;Blom, 1986;Harleman et al, 1987;Hirth, 1987;Penston & Wormsley, 1987;Strett et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

Clofibrate raises human 24 h intragastric acidity but does not affect plasma gastrin concentration.

Gavey

Smith

Nwokolo

et al. 1990

Brit J Clinical Pharma

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1 We studied the effects of acute oral dosing with clofibrate (500 mg four times daily) on 24 h intragastric acidity and plasma gastrin concentration in 12 healthy female subjects. 2 The 24 h integrated intragastric acidity rose from 429 mmol I1 h (95% CI before dosing to 527 mmol 1-1 h (95% CI 385-664) on the day of dosing (+23%; P = 0.041), but no change was observed in the 24 h integrated plasma gastrin concentration: 420 pmol I1-h (95% CI 282-499) before and 389 pmol I1-h (95% CI 249-489) during dosing (P = 0.182). 3 We conclude that clofibrate has no acute antisecretory effect on the human stomach, and that human gastrin-induced enterochromaffin-like cell proliferation is unlikely with this drug.

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“…Eighty-microliter aliquots of each homogenate were incubated for 1 h with 0.02 mCi͞ml L-[ 14 C]histidine (specific activity, 50 mCi͞mmol; Perkin-Elmer Life Sciences) in the presence of 5 ϫ 10 Ϫ4 M L-histidine and 10 Ϫ5 M pyridoxal-5-phosphate at 37°C under nitrogen. The total reaction volume was 160 l. The 14 CO 2 formed during the reaction was trapped in protosol solution and measured by liquid scintillation counting (16,17). The enzyme activity was expressed as pmol of CO 2 per mg of mucosa per h. The experiment was approved by the University Hospital of Trondheim Animal Research Committee.…”

Section: Measurement Of Gastric Ph and Oxyntic Mucosal Histidine Decamentioning

confidence: 99%

Identification of a series of CCK-2 receptor nonpeptide agonists: Sensitivity to stereochemistry and a receptor point mutation

Kopin

McBride

Chen

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

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Plasma gastrin and gastric enterochromaffinlike cell activation and proliferation

Cited by 476 publications

References 9 publications

Changes in Subcellular Structures of Parietal Cells in the Rat Gastric Gland after Omeprazole.

Changes in Subcellular Structures of Parietal Cells in the Rat Gastric Gland after Omeprazole.

Clofibrate raises human 24 h intragastric acidity but does not affect plasma gastrin concentration.

Identification of a series of CCK-2 receptor nonpeptide agonists: Sensitivity to stereochemistry and a receptor point mutation

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