Plasma ghrelin following cure of Helicobacter pylori

Abstract

After H. pylori cure, plasma ghrelin increased profoundly in asymptomatic subjects. This could lead to increased appetite and weight gain, and contribute to the increasing obesity seen in Western populations where H. pylori prevalence is low. This plausible biological mechanism links H pylori, through increasing obesity and GORD, to the increase in oesophageal adenocarcinoma observed in the West.

Is Helicobacter Pylori Associated with an Increased Complication Rate after Sleeve Gastrectomy?

“…The effect of H. pylori on weight loss after bariatric surgery was not significant according to Azuma and Nwokolo. 10,11 They correlated the presence of H. pylori and hormones levels (ghrelin and leptin) and showed no significant differences in terms of weight loss.…”

Helicobacter pylori persistence: biology and disease

“…Evidence conflicts as to whether serum ghrelin levels are higher in H. pylori-negative persons (109, S101), but they increase after H. pylori eradication (6). In an animal model, immunity to Helicobacter is associated with upregulation of adipocyte genes, including adipsin, resistin, and adiponectin (110).…”

“…4). New studies suggest other important impacts of H. pylori colonization on human physiology (5,6).…”

Drosophila lifespan enhancement by exogenous bacteria

“…Because dietary restriction can dramatically alter longevity, it is necessary to control for this factor. In mammals, gastric bacteria can affect the activity of the appetite-regulating factors ghrelin, gastrin, and leptin (27,28). Drosophila feeding can be negatively affected by Fig.…”

“…Mammals use bacteria to extract and process nutrients from the diet (22), to assist in the development and function of the gut and the enteric nervous system (23), and for conditioning of the immune system (24)(25)(26). Helicobacter pylori participates in appetite regulation (27,28); however, on the other hand, it is linked to ulcers and gastric cancer (29).…”