Plasma ghrelin levels after laparoscopic sleeve gastrectomy in obese individuals

Sharma, Garima; Nain, Prabhdeep Singh; Sethi, Pulkit; Ahuja, Ashish; Sharma, Sarit

doi:10.4103/ijmr.ijmr_984_18

Cited by 11 publications

(6 citation statements)

References 17 publications

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“…They also found an increase in plasma ghrelin levels after weight loss induced by caloric restriction, suggesting that GB bypass itself is associated with decreased levels of circulating ghrelin. However, a study carried out by Sharma et al, (2019) found a significant weight loss and decrease in BMI at three and six months postoperatively after SG. This difference may be attributed to in the current study we did not study the rhythm of ghrelin after two months [19] .…”

Section: Discussionmentioning

confidence: 92%

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The Impact of Bariatric Procedures on Local Gastrointestinal Hormones

Elsageer

Mahran

Mohamed

et al. 2022

Minia Journal of Medical Research

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Background: Many of the beneficial metabolic effects of bariatric surgery have been attributed to altered peptide hormone profiles, especially involving pancreatic and gut peptides. We aimed to assess the impact of sleeve gastrectomy (SG), one anastomosis gastric bypass (OAGB), and sleeve gastrectomy with loop bipartition (SGLB) on gastrointestinal tract hormones. Methods: A case series analysis was carried out at our institution from February 2018 to February 2021. This study included 3 groups subjected to different operations; each group consisted of 50 patients. Results: This study included 132 women (88%) and 18 men (12%). Mean age in SG, OAGB and SGLB were 33.5 SD3.89, 30.9 SD7.2, and 40.3 SD6.89 respectively. The percentage of change in Peptide YY levels two weeks postoperatively in SG, OAGB, and SGLB were 29.1%, 40.1%, and 65.6% respectively. In Glucagonlike peptide-1 were 19.3%, 34.1% and 32.8% respectively. However, the percent of change in Ghrelin level two weeks were 36.5%, 50%, and 50.6% respectively. Finally, the percent change in secretin hormone levels were 61.5%, 56.9%, and 46.3% respectively. Conclusions: Differences in gastrointestinal hormones that regulate energy and glucose homeostasis are a possible mechanism for more significant weight loss after SGLB and OAGB compared to SG.

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Section: Discussionmentioning

confidence: 92%

“…However, a study carried out by Sharma et al, (2019) found a significant weight loss and decrease in BMI at three and six months postoperatively after SG. This difference may be attributed to in the current study we did not study the rhythm of ghrelin after two months [19] .…”

Section: Discussionmentioning

confidence: 92%

The Impact of Bariatric Procedures on Local Gastrointestinal Hormones

Elsageer

Mahran

Mohamed

et al. 2022

Minia Journal of Medical Research

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“…It is known that, under normal conditions, ghrelin production in the stomach and secretion into the blood are decreased during satiety, while production increases during fasting and starvation, resulting in an increase in ghrelin concentration in the blood [ 26 ]. Conversely, blood ghrelin concentration and appetite have been found to be decreased in patients who have been administered with anticancer drugs, patients with gastric mucosal atrophy or gastrectomy [ 42 , 43 , 44 , 45 ], and in animal models of these conditions [ 22 , 46 , 47 , 48 , 49 ]. Blood ghrelin levels have been found to be reduced in mice treated with the anticancer drug cisplatin [ 46 , 47 ] and classical SSRIs [ 49 ], as well as during psychological stress [ 22 ] and cancer cachexia [ 48 ].…”

Section: Abnormal Ghrelin Secretion and Changes In Reactivitymentioning

confidence: 99%

Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease

Yamada¹

2021

IJMS

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Growth hormone secretagogue receptor 1a (GHS-R1a), which is one of the G protein-coupled receptors (GPCRs), is involved in various physiological actions such as energy consumption, growth hormone secretion promoting action, and cardiovascular protective action. The ligand was searched for as an orphan receptor for a while, but the ligand was found to be acylated ghrelin (ghrelin) discovered by Kangawa and Kojima et al. in 1999. Recently, it has also been reported that dysregulation of GHS-R1a mediates reduced feeding in various diseases. On the other hand, since the physiological effects of ghrelin have been studied exclusively in male mice, few studies have been conducted on gender differences in ghrelin reactivity. In this review, we describe (1) the characteristics of GHS-R1a, (2) the role of ghrelin in hypophagia due to stress or anticancer drugs, and (3) the gender differences in the physiological effects of GHS-R1a and the influence of stress on it.

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“…This type of cell produces the appetite-stimulating hormone ghrelin. Ghrelin production is suppressed following LSG, leading to decreased stimulation of the hunger center [ 21 ].…”

Section: Gastroesophageal Reflux Disease and Laparoscopic Sleeve Gastrectomymentioning

confidence: 99%

Relationship between gastroesophageal reflux disease and laparoscopic sleeve gastrectomy: a narrative review.

Mocian¹,

Coroș²

2021

Videosurgery and Other Miniinvasive Techniques

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This paper aims to revisit the relationship between gastroesophageal reflux disease and laparoscopic sleeve gastrectomy in obese patients by reviewing the recent available literature, in the form of a narrative review. The interpretation of the current evidence is challenged by the fact that published data are contradictory and comparison between studies is difficult. Most studies investigate the presence of gastroesophageal reflux disease by assessing only the symptoms reported by patients. A few studies have objectively investigated gastroesophageal reflux disease by functional tests and endoscopic evaluation. Also, the surgical technique of laparoscopic sleeve gastrectomy plays an important role in the incidence of postoperative gastroesophageal reflux disease. In conclusion, surgeons must be aware of the existence of gastroesophageal reflux disease and, at the same time, patients should be informed regarding the possible effect of laparoscopic sleeve gastrectomy on gastroesophageal reflux disease.

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Plasma ghrelin levels after laparoscopic sleeve gastrectomy in obese individuals

Cited by 11 publications

References 17 publications

The Impact of Bariatric Procedures on Local Gastrointestinal Hormones

The Impact of Bariatric Procedures on Local Gastrointestinal Hormones

Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease

Relationship between gastroesophageal reflux disease and laparoscopic sleeve gastrectomy: a narrative review.

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