2024
DOI: 10.1101/2024.07.30.24311203
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Plasma Glial Fibrillary Acidic Protein and Neurofilament Light are Elevated in Bipolar Disorder: Evidence for Neuroprogression and Astrocytic Activation

Matthew Kang,
Dhamidhu Eratne,
Olivia Dean
et al.

Abstract: Importance: Recent methodological developments allow us to measure small amounts of brain-specific proteins in the blood, including neurofilament light chain (NfL), a marker of axonal pathology, and glial fibrillary acidic protein (GFAP), a marker of astrocytic activation. Given the evidence of potential astroglial pathology and neuronal dysfunction in bipolar disorder, these markers may provide further insight into its pathophysiology. Objective: We investigated plasma NfL and GFAP levels in people with bipol… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2025
2025
2025
2025

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
references
References 45 publications
(54 reference statements)
0
0
0
Order By: Relevance