Plasma glucose and insulin responses after consumption of breakfasts with different sources of soluble fiber in type 2 diabetes patients: a randomized crossover clinical trial

Carvalho, Cláudia Mesquita de; Paula, Tatiana Pedroso de; Viana, Luciana Verçoza; Machado, Vitória Mt; Almeida, J. C.; Azevedo, Mirela Jobim de

doi:10.3945/ajcn.117.157263

Cited by 45 publications

(46 citation statements)

References 35 publications

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“…Many studies have reported that dietary fibers can slow down food digestion and nutrient absorption influencing the metabolism of carbohydrates (Chang et al, 2002;de Carvalho et al, 2017;Reverri et al, 2017). In addition to controlling blood glucose levels, dietary fibers also regulate bile acid metabolism and lipid concentrations in F I G U R E 2 Effects of pre-germinated brown rice extract on AMP-activated protein kinase, insulin receptor, insulin receptor substrate-1, insulin receptor substrate-2, peroxisome proliferator-activated receptor-γ, phosphatidylinositol-3-kinase, Akt, glucose transporter-1, glucose transporter-4, and glucokinase protein expression levels in the skeletal muscle of high-fat diet (HFD)-fed mice.…”

Section: Discussionmentioning

confidence: 99%

Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome

Hao

Lin

et al. 2019

J Food Biochem

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This study examined the effect of pre‐germinated brown rice extract (PGBRE), containing no dietary fibers, but γ‐oryzanol, γ‐aminobutyric acid (GABA), flavonoids, and anthocyanidin, on high‐fat‐diet (HFD)‐induced metabolic syndrome. C57BL/6 mice were divided into five groups: regular diet, HFD, HFD with oral PGBRE 30, 300, or 600 mg/kg per day for 18 weeks. In the HFD group, higher body and liver weight gain, hyperglycemia, HbA1c, and insulin; higher TG, TC, LDL‐C, non‐HDL, atherosclerosis index, lower HDL, adiponectin in blood; higher TG in the liver; higher TG, bile acid in feces; and lower protein levels of AMP‐activated protein kinase, insulin receptor, insulin receptor substrate‐1, insulin receptor substrate‐2, peroxisome proliferator‐activated receptor‐γ, phosphatidylinositol‐3‐kinase, Akt/PKB, glucose transporter‐1, glucose transporter‐4, glucokinase in the skeletal muscle; lower glucagon‐like peptide 1 (GLP‐1) in the intestine; higher sterol regulatory element‐binding protein‐1 (SREBP‐1), stearoyl‐CoA desaturase 1 (SCD‐1), fatty acid synthase (FAS), 3‐hydroxy‐3‐methylglutaryl‐CoA reductase, proprotein convertase subtilisin/kexin type 9 (PCSK9), and lower PPAR‐α, low‐density lipoprotein receptor, cholesterol‐7α‐hydroxylase in the liver; higher SREBP‐1, SCD‐1, FAS, and lower PPAR‐α, adiponectin in the adipose tissue were found. In HFD + PGBRE groups, the above biochemical parameters were improved. Practical applications According to the results, we suggested that dietary fibers played a minor role in this study. Extract of PGBR, excluding dietary fiber, showed beneficial activity to ameliorate metabolic syndrome. γ‐oryzanol, GABA, flavonoids, and anthocyanidin in PGBRE can inhibit HFD‐induced metabolic syndrome and we demonstrated clearly its action mechanisms. This is the first report to examine the relation between PGBRE, GLP‐1, and PCSK9. Taken together, PGBRE can potentially be used to develop a good supplement to control metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%

Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome

Hao

Lin

et al. 2019

J Food Biochem

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“…Given that obese dogs frequently exhibit an impaired glycaemic response, including hyperglycaemia, hyperinsulinaemia and insulin resistance, the consumption of fermentable fibres may improve these measures across multiple meals. In addition, human studies have shown that consumption of initial meals high in fibre, especially those that are soluble and/or fermentable, can curb the glycaemic response of a high-glycaemic second meal (13)(14)(15)(16) . The overarching hypothesis is that the production of SCFA (acetate; butyrate; propionate) produced from fermentation of fibre in the large bowel modulates the observed effects by delaying gastric emptying (17) , down-regulating lipolysis in adipocytes (18) , increasing glucose utilisation in glycolysis and decreasing glucose production (19) and increasing postprandial insulin and GLP-1 production (8) .…”

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confidence: 99%

Effects of prebiotic inulin-type fructans on blood metabolite and hormone concentrations and faecal microbiota and metabolites in overweight dogs

et al. 2018

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Because obesity is associated with many co-morbidities, including diabetes mellitus, this study evaluated the second-meal effect of a commercial prebiotic, inulin-type fructans, and the effects of the prebiotic on faecal microbiota, metabolites and bile acids (BA). Nine overweight beagles were used in a replicated 3×3 Latin square design to test a non-prebiotic control (cellulose) against a low (equivalent to 0·5 % diet) and high dose (equivalent to 1·0 % diet) of prebiotic over 14-d treatments. All dogs were fed the same diet twice daily, with treatments provided orally via gelatin capsules before meals. On days 13 or 14 of each period, fresh faecal samples were collected, dogs were fed at 08.00 hours and then challenged with 1 g/kg body weight of maltodextrin in place of the 16.00 hours meal. Repeated blood samples were analysed for glucose and hormone concentrations to determine postprandial incremental AUC (IAUC) data. Baseline glucose, insulin and active glucagon-like peptide-1 levels were similar between all groups (P>0·10). Glucose and insulin IAUC after glucose challenge appeared lower following the high dose, but did not reach statistical relevance. Prebiotic intervention resulted in an increase in relative abundance of some Firmicutes and a decrease in the relative abundance of some Proteobacteria. Individual and total faecal SCFA were significantly increased (P<0·05) following prebiotic supplementation. Total concentration of excreted faecal BA tended to increase in dogs fed the prebiotic (P=0·06). Our results indicate that higher doses of inulin-type prebiotics may serve as modulators of gut microbiota, metabolites and BA pool in overweight dogs.

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“…Fiber consumption is relevant for human health improving intestinal motility (Bernaud and Rodrigues, 2013). Besides that, it helps in the treatment of Diabetes Mellitus, reducing blood glucose (Carvalho et. al., 2017), and obesity (Post et al, 2012), contributing to reduce the risk of both cardiovascular and coronary diseases once it is related to the improvement of modifiable risk factors such as hypertension and hypercholesterolemia (Threapleton et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Bromatology, food chemistry and antioxidant activity of Xanthosoma sagittifolium (L.) Schott

2019

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Taioba or Cocoyam - Xanthosoma sagittifolium (L.) Schott - leaves and petioles consumption is almost restricted to Brazilian traditional communities because the lack of knowledge about their chemical and nutritional features. This study was carried out to determine the Taioba leaves and petioles chemical properties (moisture, fixed mineral residue, Calcium, Magnesium, proteins, lipids, dietary fiber and carbohydrates) were quantified; Calcium oxalate was evaluated as an anti-nutritional factor. Bioactive compounds (vitamin C, chlorophyll, carotenoids, lycopene and phenolic compounds) were also determined. Antioxidant capacity was evaluated by DPPH and ABTS methods. Taioba leaves and petioles present greater quantity of proteins, fibers, Calcium, Magnesium and vitamin C than some conventional plants used as salad. The amount of Calcium oxalate was not considered harmful to human consume. Antioxidant activity related to Taioba bioactive compounds has functional and nutraceutical abilities, which opens promising prospects for its use.

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Plasma glucose and insulin responses after consumption of breakfasts with different sources of soluble fiber in type 2 diabetes patients: a randomized crossover clinical trial

Cited by 45 publications

References 35 publications

Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome

Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome

Effects of prebiotic inulin-type fructans on blood metabolite and hormone concentrations and faecal microbiota and metabolites in overweight dogs

Bromatology, food chemistry and antioxidant activity of Xanthosoma sagittifolium (L.) Schott

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