Plasma glutathioneS-transferase P1-1 levels in patients with head and neck squamous cell carcinoma

Ophuis, Michael B. Oude; Mulder, T.P.J.; Peters, Wilbert H.M.; Manni, Johannes J.

doi:10.1002/(sici)1097-0142(19980615)82:12<2434::aid-cncr18>3.0.co;2-q

Cited by 14 publications

(11 citation statements)

References 12 publications

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“…[18][19][20][21]23,24 Contrary to reports, 7,9,12,13 the major A allele at 12,308 np, G allele at 10,398 np, and T allele at 10,400 np were considered risk alleles because they increased the risk of cancer in this population.…”

Section: Risk Genotypes/allelesmentioning

confidence: 99%

“…15,16 Different classes of GST enzymes, which are mostly present in cytosol, generally detoxify tobacco carcinogens and polymorphisms at GSTM1, GSTP1, and GSTM3 have been shown to be associated with increased risk of cancers in different populations. [17][18][19][20][21] A few recent reports also demonstrated localization of GSTP1, GSTA1, GSTK1, and GSTM1 enzymes in the inner membrane of mitochondria in human, rat, and mice. 22 The function of these proteins has been attributed to the inactivation of ROS generated in mitochondria.…”

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confidence: 98%

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Increased risk of oral cancer in relation to common Indian mitochondrial polymorphisms and Autosomal GSTP1 locus

Datta

Majumder

Biswas

et al. 2007

Cancer

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BACKGROUND.Polymorphisms at mitochondrial (mt) loci could modulate the risk of diseases including cancers. Here the mtDNA polymorphisms at 12,308 nucleotide pairs (np), 11,467 np, 10,400 np, and 10,398 np were studied to examine the association with the risk of oral cancer and leukoplakia, alone and in combination with polymorphisms at the GST loci.METHODS.Polymorphisms at mt loci were screened in 310 cancer, 224 leukoplakia, and 389 control individuals by polymerase chain reaction (PCR) restriction length polymorphism (RFLP) and most of the GST genotype data were taken from previously published reports. Data were analyzed to determine the risk of the diseases.RESULTS.The major allele, A, at 12,308 np on tRNALeu (CUN), increased the risk of cancer (odd ratio [OR] of 1.7; 95% confidence interval [95% CI], 1.1–2.6) but not that of leukoplakia. The same allele also appeared to increase the risk of cancer in smokers (OR of 4.0; 95% CI, 1.1–14.4), who are mostly males (OR of 1.8; 95% CI, 1.1‐3‐2), but not in smokeless tobacco users, who are mostly females. The major allele A at 11467 np demonstrated identical results as the major allele, A, at 12,308 np. The major alleles G at 10,398 np and T at 10,400 np (ie, M‐haplogroup) increased the risk of cancer significantly in smokers (OR of 2.6; 95% CI, 1.2–5.7 and OR of 2.4; 95% CI, 1.1–5.1, respectively). The risk‐risk genotype‐allele combination at GSTP1 and mt12308 np loci increased the risk of cancer (OR of 2.6; 95% CI, 1.4–4.9) when compared with the nonrisk‐nonrisk combination in leukoplakia patients.CONCLUSIONS.Polymorphisms at the mt loci alone and in combination with the risk genotype at GSTP1 increased the risk of oral cancer. Thus, risk genotypes from 2 different organelles may work in combination to increase the risk of oral cancer. Cancer 2007. © 2007 American Cancer Society.

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Section: Risk Genotypes/allelesmentioning

confidence: 99%

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confidence: 98%

Increased risk of oral cancer in relation to common Indian mitochondrial polymorphisms and Autosomal GSTP1 locus

Datta

Majumder

Biswas

et al. 2007

Cancer

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“…(11). Four members of the GST genes such as GSTM1, GSTT1, GSTP1, and GSTM3 display polymorphisms that have been associated with increased risk of cancers (12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Increased Risk of Oral Leukoplakia and Cancer Among Mixed Tobacco Users Carrying XRCC1 Variant Haplotypes and Cancer Among Smokers Carrying Two Risk Genotypes: One on Each of Two Loci, GSTM3 and XRCC1 (Codon 280)

Majumder

Sikdar

Paul

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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An individual's susceptibility to oral precancer and cancer depends not only on tobacco exposure but also on the genotypes/haplotypes at susceptible loci. In this hospitalbased case-control study, 310 cancer patients, 197 leukoplakia patients, and 348 controls were studied to determine risk of the disease due to polymorphisms at three sites on XRCC1 and one site on XRCC3. Independently, variant genotypes on these loci did not modulate risk of leukoplakia and cancer except for the XRCC1 (codon 280) risk genotype in exclusive smokeless tobacco users with leukoplakia [odds ratios (OR), 2.4; 95% confidence intervals (CI), 1.0-5.7]. But variant haplotypes, containing one variant allele, on XRCC1 increased the risk of leukoplakia (OR, 1.3; 95% CI, 1.0-1.7). Among stratified samples, mixed tobacco users, carrying variant haplotypes, also had increased risk of both leukoplakia (OR, 2.2; 95% CI, 1.3-3.9) and cancer (OR, 1.9; 95% CI, 1.2-3.1). In a previous study on this population, it was shown that the GSTM3 (A/A) genotype increased the risk of oral leukoplakia and cancer among smokers, which has also been substantiated in this study with expanded sample sizes. The simultaneous presence of two risk genotypes in smokers, one on each of two loci, GSTM3 and XRCC1 (codon 280), increased the risk of cancer (OR, 2.4; 95% CI, 1.0-5.8). Again, smokers carrying two risk genotypes, one on each of two loci, GSTM3 and XRCC1 (codon 399), were also overrepresented in both leukoplakia and cancer populations (P trend = 0.02 and 0.04, respectively) but enhancement of risks were not observed; probably due to small sample sizes. Therefore, the presence of variant haplotypes on XRCC1 and two risk genotypes, one on each of two loci, GSTM3 and XRCC1, could be useful to determine the leukoplakias that might progress to cancer in a group of patients. (Cancer Epidemiol Biomarkers Prev 2005;14(9):2106 -12)

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“…GSTP1 is most abundant among GST enzymes and expressed in most human tissues, including oral cavity. This enzyme is found in greatest concentration in the oral and pharyngeal mucosa of head and neck compared with the other GST enzymes 18. Apart from the wild‐type GSTP1*A allele, 3 variant alleles ( GSTP1*B , GSTP1*C and GSTP1*D ) of GSTP1 have been described.…”

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confidence: 99%

Glutathione S‐transferase M3 (A/A) genotype as a risk factor for oral cancer and leukoplakia among Indian tobacco smokers

Sikdar

Paul

Roy

2003

Intl Journal of Cancer

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Polymorphism in glutathione S-transferase (GST) genes, causing variations in enzyme activities, may influence susceptibility to oral cancer and leukoplakia in smokers and/or smokeless tobacco users. In this case-control study consisting of 109 leukoplakia and 256 oral cancer patients and 259 controls, genotype frequencies at GSTM1, GSTT1, GSTM3 and GSTP1 loci were determined by polymerase chain reactionrestriction fragment length polymorphism methods and analyzed by multiple logistic regression to determine the risks of the diseases. There were no significant differences in the distributions of GSTM1, GSTM3 and GSTT1 genotypes in patients and controls when all individuals were compared. In contrast, frequencies of ile/ile genotype at codon 105 and variant val-ala haplotype of GSTP1 was significantly higher (OR ‫؍‬ 1.5; 95% CI ‫؍‬

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Plasma glutathioneS-transferase P1-1 levels in patients with head and neck squamous cell carcinoma

Cited by 14 publications

References 12 publications

Increased risk of oral cancer in relation to common Indian mitochondrial polymorphisms and Autosomal GSTP1 locus

Increased risk of oral cancer in relation to common Indian mitochondrial polymorphisms and Autosomal GSTP1 locus

Increased Risk of Oral Leukoplakia and Cancer Among Mixed Tobacco Users Carrying XRCC1 Variant Haplotypes and Cancer Among Smokers Carrying Two Risk Genotypes: One on Each of Two Loci, GSTM3 and XRCC1 (Codon 280)

Glutathione S‐transferase M3 (A/A) genotype as a risk factor for oral cancer and leukoplakia among Indian tobacco smokers

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