Plasma gonadotrophins profile in relation to body composition in underprivileged boys

Abstract

The plasma concentrations of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were measured in 250 underprivileged boys (UP boys) aged 9.0 to 15.9 years living in a State orphanage and in 357 clinically healthy boys of the same age (with weight and height between the 3rd and 97th percentile for Mexican standards) and correlated with chronological age (CA), weight, height and calculated lean body mass (LBM) and total body fat (TBF). On a group basis, UP boys had a 2 years delay in the onset of clinical signs of puberty as well as a mild degree of malnutrition. In both groups of boys, the mean weights at time of initiation of the adolescent growth spurt in weight and at time of peak velocity of weight gain were very close to each other and similar to the values reported for Caucasian boys. The same phenomenon was true for their heights and the amounts of LBM and TBF (whether as an absolute value or as a percentage of body weight). Based on CA mean plasma FSH concentrations in UP boys were lower than normal from 11.0 to 13.9 years and the subsequent steep rise of this hormone occurred 2 years later than in healthy boys; however, when analyzed as a function of body weight, height or LMB, no such quantitative or qualitative differences emerged. On the other hand, mean plasma LH concentrations in UP boys were higher than in healthy boys only up to certain CA (< 12.9 years), weight (< 42.9 kg), height (< 147.0 cm), LBM (< 35.0 kg) or TBF (< 9.0 kg); however, no steep rise in plasma LH was observed in contrast to healthy boys. Therefore, although from a chronologic view point UP boys had a delayed onset in plasma gonadotrophins changes, they did occur in association with the attainment of similar weight, height and LBM as in healthy boys. This observation seems to support further the hypothesis of a close association between a 'critical' level of LBM (and not body fat) and the initiation of puberty, both in healthy and multiply deprived boys.

Age, environmental factors and prostatic cancer

“…In black SA boys versus white boys, in this study high LH levels are associated with low DHEA and androstenedione levels. Interestingly, Parra et al (58) reported higher plasma levels of LH in underpriviledged Mexican boys up to 13 years of age who concomitantly had a two year delay in puberty when compared with 'well to do' Mexican boys. Thus in less socioeconomically advanced societies late maturation in children may be associated not only with an altered CNS-hypothalamic maturation but also delayed adrenal stimulation.…”