Plasma gp96 is a Novel Predictive Biomarker for Severe COVID-19

Wei, Rongguo; Zhou, Biyan; Li, Shaohua; Zhong, Debin; Li, Boan; Qin, Jianqiu; Zhao, Liping; Qin, Lixian; Hu, Jun; Wang, Jiuru; Yang, Shixiong; Zhao, Jingming; Meng, Songdong

doi:10.1128/spectrum.00597-21

Cited by 2 publications

(2 citation statements)

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“… 90 , 91 Plasma gp96 level has been associated with IL-6 and disease severity in COVID-19 patients. 92 Plasma gp96 had reliable power to distinguish non-serious COVID-19 patients from severe COVID-19 patients. 92 Immune system molecules are among the most studied molecules in studies where molecular biomarkers are sought.…”

Section: Introductionmentioning

confidence: 92%

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SARS-CoV-2 Infection and Candidate Biomarkers

Uzunçakmak¹

2023

Eurasian J Med

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Severe acute respiratory syndrome coronavirus 2 is a virus that can still infect individuals and whose deadly effects continue despite the current vaccines and drugs. Since 2019, many studies on the pathogenesis of the disease have been completed and continue to be done. In addition to the diagnosis and treatment of the disease, many molecules that can be markers of the disease have been investigated. In the early stages of the pandemic, many nonspecific and infection-related laboratory findings and chest computed tomography were used to obtain information about the diagnosis of the disease. The more individual molecules became associated with the disease yet. The purpose of this review is to summarize the impact and role of many molecules associated with coronavirus disease-2019 infection that have been previously used and newly revealed. Numerous studies are summarized in this review. The obtained data show that previously used laboratory findings and new potential biomarkers are not specific to the disease. New potential biomarkers have been associated with the severity of the disease itself, as can be seen with lung imaging and even with routine laboratory findings. One of the important points that are seen frequently in studies is that the effectiveness of these molecules has been shown not only in coronavirus disease-2019 infection but also in many other diseases. This removes the pathogenesis of the disease from being a unique mechanism created by the Severe acute respiratory syndrome coronavirus 2 and provides a general perspective formed by viral or bacterial infections. However, there are still many molecular changes that need to be investigated. Future studies will continue to update themselves with the mutations of the virus.

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Section: Introductionmentioning

confidence: 92%

“… 92 Plasma gp96 had reliable power to distinguish non-serious COVID-19 patients from severe COVID-19 patients. 92 Immune system molecules are among the most studied molecules in studies where molecular biomarkers are sought. Immune overactivation and cytokine storm are part of the COVID-19 infection.…”

Section: Introductionmentioning

confidence: 92%