Plasma H<sub>2</sub>S predicts coronary artery lesions in children with Kawasaki disease

Sun, Yan; Yuan, Yue; Yan, Hui; Wan, Hong; Li, Xueying; Chen, Siyao; Li, Hongxia; Tang, Chaoshu; Du, Junbao; Liu, Guiying; Jin, Hongfang

doi:10.1111/ped.12631

Cited by 10 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3-MST knockout mice developed hypertension and cardiac hypertrophy [17]. Second, are observations that impaired H 2 S-generating pathways were found in CVDs, including atherosclerosis [24], coronary artery disease [25], stroke [26], and peripheral vascular disease [15].…”

Section: The Role Of H 2 S In the Pathophysiology Of Cvdmentioning

confidence: 99%

Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?

Hsu

Tain

2021

Antioxidants

View full text Add to dashboard Cite

The cardiovascular system can be programmed by a diversity of early-life insults, leading to cardiovascular disease (CVD) in adulthood. This notion is now termed developmental origins of health and disease (DOHaD). Emerging evidence indicates hydrogen sulfide (H2S), a crucial regulator of cardiovascular homeostasis, plays a pathogenetic role in CVD of developmental origins. Conversely, early H2S-based interventions have proved beneficial in preventing adult-onset CVD in animal studies via reversing programming processes by so-called reprogramming. The focus of this review will first summarize the current knowledge on H2S implicated in cardiovascular programming. This will be followed by supporting evidence for the links between H2S signaling and underlying mechanisms of cardiovascular programming, such as oxidative stress, nitric oxide deficiency, dysregulated nutrient-sensing signals, activation of the renin–angiotensin system, and gut microbiota dysbiosis. It will also provide an overview from animal models regarding how H2S-based reprogramming interventions, such as precursors of H2S and H2S donors, may prevent CVD of developmental origins. A better understanding of cardiovascular programming and recent advances in H2S-based interventions might provide the answers to bring down the global burden of CVD.

show abstract

Section: The Role Of H 2 S In the Pathophysiology Of Cvdmentioning

confidence: 99%

Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?

Hsu

Tain

2021

Antioxidants

View full text Add to dashboard Cite

show abstract

“…Plasma H 2 S concentrations were measured using the sulfide-sensitive electrode method (PXS-270, Shanghai, China) as described by Sun et al [6].…”

Section: Determination Of H 2 S In Plasmamentioning

confidence: 99%

Expression of H₂S in Gestational Diabetes Mellitus and Correlation Analysis with Inflammatory Markers IL-6 and TNF-α

Teng

Xuan

Jiang

et al. 2020

Journal of Diabetes Research

View full text Add to dashboard Cite

Background. Gestational diabetes mellitus (GDM) is a severe threat to the health of both mother and child. The pathogenesis of GDM remains unclear, although much research has found that the levels of hydrogen sulfide (H2S) play an important role in complications of pregnancy. Methods. We collected venous blood samples from parturient women and umbilical vein blood (UVB) and peripheral venous blood (PVB) samples one hour after childbirth in the control, GDM-, and GDM+ groups in order to determine the concentration of glucose and H2S in plasma; to measure levels of TNF-α, IL-1β, IL-6, TGF-β1, and ADP in parturient women and the UVB of newborns; and to find the correlation of H2S with regression. Results. We found that, with the elevation of glucose, the level of H2S was decreased in GDM pregnant women and newborns and the concentrations of IL-6 and TNF-α were upregulated. With regression, IL-6 and TNF-α concentrations were positively correlated with the level of blood glucose and negatively correlated with H2S concentration. Conclusion. This study shows that downregulation of H2S participates in the pathogenesis of GDM and is of great significance in understanding the difference of H2S between normal and GDM pregnant women and newborns. This study suggests that IL-6 and TNF-α are correlated with gestational diabetes mellitus. The current study expands the knowledge base regarding H2S and provides new avenues for exploring further the pathogenesis of GDM.

show abstract

“…Furthermore, extracoronary echocardiographic ndings and Z-values were also found to have predictive value for CAL [28,33,34]. Compared to those studies, investigation on blood-based biomarkers avoided the in uence of variance in equipment and technicians.…”

Section: Discussionmentioning

confidence: 99%

Association Between Clinical Risk Factors and Coronary Artery Lesions in Children with Kawasaki Disease

Yang

Chen

Deng

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Kawasaki disease (KD) is one of the leading causes of acquired coronary artery diseases in childhood. In KD patients, the evidence on the association between easy-to-assess clinical risk factors and development of coronary artery lesion (CAL). Our study aimed to determine the clinical biomarkers that were associated with latent occurrence of CAL in pediatric patients with KD. Methods: 260 pediatric KD patients were recruited. The outcome of our study is CAL, including coronary dilation, coronary aneurysm, and intimal thickening of coronary arteries. Data of general information, medical history, results of laboratory examinations and echocardiography data were collected. Logistic regression method was carried out to explore the associations between biomarkers and each CAL. Results: Sixty-six (25.4 %), thirty-nine (15 %) and fifty-six patients (21.5 %) of the participants had coronary dilation, coronary aneurysm, and intimal thickening of coronary arteries, respectively. Single-variable analysis found age, gender, duration of fever, time of initial use of IVIG, ESR, WBC, time of platelet increase, maximum value of platelet, albumin and IgG level were associated with CAL. In multivariable logistic analysis, younger in age and male were associated with all three outcomes of CAL. Lower serum albumin level and later initial use of IVIG were linked to higher risk of coronary dilation and coronary aneurysm.Conclusion: In a Chinese pediatric population of KD, younger in age, male, lower serum albumin lever, and later initial use of IVIG were risk factors of CAL. Our findings had high practicability to be implemented in clinical practice, however, is to be verified by future studies.

show abstract

Plasma H₂S predicts coronary artery lesions in children with Kawasaki disease

Abstract: Plasma H2S level in the acute period is a potentially useful biomarker for predicting CAL in KD children.

Cited by 10 publications

References 27 publications

Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?

Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?

Expression of H₂S in Gestational Diabetes Mellitus and Correlation Analysis with Inflammatory Markers IL-6 and TNF-α

Association Between Clinical Risk Factors and Coronary Artery Lesions in Children with Kawasaki Disease

Contact Info

Product

Resources

About

Plasma H2S predicts coronary artery lesions in children with Kawasaki disease

Abstract: Plasma H2S level in the acute period is a potentially useful biomarker for predicting CAL in KD children.

Cited by 10 publications

References 27 publications

Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?

Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?

Expression of H2S in Gestational Diabetes Mellitus and Correlation Analysis with Inflammatory Markers IL-6 and TNF-α

Association Between Clinical Risk Factors and Coronary Artery Lesions in Children with Kawasaki Disease

Contact Info

Product

Resources

About

Plasma H₂S predicts coronary artery lesions in children with Kawasaki disease

Expression of H₂S in Gestational Diabetes Mellitus and Correlation Analysis with Inflammatory Markers IL-6 and TNF-α