Plasma High-Density Lipoprotein Cholesterol in Epileptics Treated with Various Anticonvulsants

Luoma, P. V.; Myllylä, Vilho V.; Sotaniemi, Eero A.; Lehtinen, Inkeri A.; Hokkanen, E.

doi:10.1159/000115130

Cited by 32 publications

(10 citation statements)

References 10 publications

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“…Our results agree with those of most authors finding increased HDL cholesterol levels in patients receiving AEDs (14)(15)(16)(17)(18)(19)(20)(21)(22), with the exception of carbamazepine monotherapy, as reported by Luoma et al (14).…”

Section: Discussionsupporting

confidence: 93%

Physical Activity, Heath‐Related Fitness, and Health Experience in Adults with Childhood‐Onset Epilepsy: A Controlled Study

Jalava

Sillanpää

1997

Epilepsia

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Summary: Purpose: To show any possible associations between childhood-onset epilepsy and physical activity, health-related fitness, and health experience.Methods: A population-based cohort of 176 patients with epilepsy since childhood was monitored for a mean of 35 years. Patients with recurrent, unprovoked epileptic seizures with no associated initial neurologic impairment or disability, termed those with "epilepsy only" (n = loo), were compared with matched controls for self-reported physical activity, health experience, laboratory tests, body mass index, and muscle power tests.Results: On the basis of muscle tests, physical fitness proved to be significantly poorer in patients with "epilepsy only" than in matched controls. During the preceding year, 22% of patients and 24% of controls had reduced their physical activities because of some illness; only 2% reduced their physical activities because of epilepsy. No significant ~~ difference was found in blood status, except for a lower serum creatinine level in the patients. Current antiepileptic drug (AED) therapy appeared significantly associated with lower hemoglobin and creatinine levels and higher highdensity lipoprotein values. The patients perceived their health status to be comparable with that of controls, irrespective of physical inactivity, continued seizures, or AED monotherapy. However, patients receiving AED polytherapy perceived their health as rather poor or very poor significantly more often than did controls.Conclusions: Based on objective muscle tests, adults with childhood-onset "epilepsy only" have poorer physical fitness than do matched controls, but they have a feeling of good personal health.

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Section: Discussionsupporting

confidence: 93%

Physical Activity, Heath‐Related Fitness, and Health Experience in Adults with Childhood‐Onset Epilepsy: A Controlled Study

Jalava

Sillanpää

1997

Epilepsia

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“…The observed increase in HDL-c in patients treated with both nevirapine and EFV has been shown to be accompanied by an increase in levels of apo A1 in plasma. 11,27 Favorable dose-dependent increases in levels of HDL-c [28][29][30] and apo A1 31 have also been observed in patients receiving antiepileptic agents. One study suggests that the observed increase in apo A1 mRNA expression in cell lines exposed to phenobarbital is a result of an increase in apo A1 transcription.…”

Section: Discussionmentioning

confidence: 99%

The Relationships of ABCB1 3435C>T and CYP2B6 516G>T With High-Density Lipoprotein Cholesterol in HIV-Infected Patients Receiving Efavirenz

Mahungu

Nair

Smith³

et al. 2009

Clin Pharmacol Ther

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Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are associated with a favorable increase in high-density lipoprotein cholesterol (HDL-c) level. Isolated studies have found a direct correlation between efavirenz (EFV) exposure and HDL-c level changes. Here we explore the impact that drug disposition variants associated with EFV exposure have on changes in HDL-c level. Seventy-six patients on first-line EFV-based regimens were genotyped for CYP2B6 516G>T and ABCB1 3435C>T. There was a 37% increase (+0.32 mmol/l, P < 0.001) in mean HDL-c level over 48 weeks, and this was univariately associated with gender (male +0.26 mmol/l, female +0.55 mmol/l; P = 0.03), ABCB1 3435C>T (CC +0.26 mmol/l, CT +0.16 mmol/l, TT +0.54 mmol/l; P(ANOVA) = 0.003) and CYP2B6 516 G>T (GG +0.27 mmol/l, GT +0.29 mmol/l, TT +0.72 mmol/l; P(ANOVA) = 0.08). There was a significant association between the cumulative number of predictive genotypes (CYP2B6 516TT or ABCB1 3435TT) and mean HDL-c level change: (group 0 +0.20 mmol/l, group 1 +0.47 mmol/l, group 2 +1.00 mmol/l; P(ANOVA) < 0.0001). These findings need to be validated in independent cohorts.

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“…14,16 Equally, our results do not support the HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; VLDL-C = very-low-density lipoprotein cholesterol. 5,7,13,15,18 Reports on the effects of valproic acid on lipid measurements are conflicting. Statistically significant difference with respect to corresponding treatment mean (normal diet): ***P < .05.…”

Section: Discussionmentioning

confidence: 99%

Evolution of Serum Lipids and Lipoprotein (a) Levels in Epileptic Children Treated With Carbamazepine, Valproic Acid, and Phenobarbital

et al. 2006

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The concentration levels of serum lipids and lipoprotein (a) were measured in 20 children receiving carbamazepine, 25 children receiving valproic acid, and 5 children receiving phenobarbital at the following times: (1) during chronic treatment while eating a normal diet, (2) during chronic treatment while eating a low-fat diet (children treated with carbamazepine and phenobarbital with high levels of total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol), and (3) 3 months after the end of treatment with antiepileptic drugs. Patients during chronic treatment and eating a normal diet revealed significant changes in lipids, but when we reevaluated the groups of children treated with carbamazepine and phenobarbital when they were eating a low-fat diet and reevaluated the three groups of children 3 months after the end of treatment, a complete return to normal of all parameters was observed. These data demonstrate that the changes induced by these drugs are transient, reversible, and influenced by a low-fat diet. (J Child Neurol 2006;21:48-53).

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Plasma High-Density Lipoprotein Cholesterol in Epileptics Treated with Various Anticonvulsants

Cited by 32 publications

References 10 publications

Physical Activity, Heath‐Related Fitness, and Health Experience in Adults with Childhood‐Onset Epilepsy: A Controlled Study

Physical Activity, Heath‐Related Fitness, and Health Experience in Adults with Childhood‐Onset Epilepsy: A Controlled Study

The Relationships of ABCB1 3435C>T and CYP2B6 516G>T With High-Density Lipoprotein Cholesterol in HIV-Infected Patients Receiving Efavirenz

Evolution of Serum Lipids and Lipoprotein (a) Levels in Epileptic Children Treated With Carbamazepine, Valproic Acid, and Phenobarbital

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