Plasma Homocysteine

Kalantar‐zadeh, Kourosh; Block, C. De; Kopple, J D

doi:10.1097/00002480-200303000-00234

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“…In hemodialysis patients, overhydration is associated with malnutrition and inflammation, representing a strong predictor of all-cause mortality in this population [3,5,[14][15][16]. Malnutrition and inflammation often occur together and overlap, and these two entities in HD patients are viewed together as a malnutrition and inflammation complex syndrome [17 ]. Poor nutrition and inflammation indicate the presence of malnutrition inflammation complex syndrome in our deceased patients .…”

Section: Systemic Inflammation In Hd Patients May Be Related To the Presence Of Central Venous Catheters Which Is Associated With Infectimentioning

confidence: 99%

Relationship between serum leptin levels, non-cardiovascular risk factors and mortality in hemodialysis patients

Risovic

Vlatković

Popović-Pejičić

et al. 2021

Romanian Journal of Internal Medicine

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Introduction. Hemodialysis (HD) patients have higher mortality rate than the general population. Recent studies indicate a significant role of non-cardiovascular risk factors in for mortality in HD patients. Leptin is protein hormone and may indicate malnutrition in HD patients. Its role in mortality in these patients is being examined. This study aimed to investigate the correlation between serum leptin levels and non-cardiovascular risk factors and relationship between leptin level and mortality in HD patients. Methods The prospective study included 93 patients on maintenance HD and follow-up period was 12 months. We measured leptin level and evaluated non-cardiovascular risk factors: nutritional status, anemia, volemia, parameters of mineral and bone disorder. Results. Out of 93 patients 9 died during study and 1 underwent kidney transplantation. Malnutrition and hypervolemia were two main non-cardiovascular risk factors among deceased subjects. Leptin showed a significant direct correlation with nutritional BMI (r = 0.72, P <0.001), fat tissue index (r = 0.74, P <0.001) and statistically significant inverse correlation with leantissue index (r = -0.349, P <0.05) and inverse correlation with volemic parameters (overhydration / extracellular water ratio (r = -0.38, P <0.001), but no association with anemia and mineral bone parameters was observed. Elevated leptin levels were associated with better survival. However, no statistically significant difference in survival rates was observed between the study groups (Log-Rank P =0.214, Breslow P =0.211, Tarone-Ware P=0.212). Conclusion: Deceased patients had significantly lower leptin values. Leptin was associated with two non-cardiovascular risk factors for mortality: malnutrition and hypervolemia.

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Section: Systemic Inflammation In Hd Patients May Be Related To the Presence Of Central Venous Catheters Which Is Associated With Infectimentioning

confidence: 99%

Relationship between serum leptin levels, non-cardiovascular risk factors and mortality in hemodialysis patients

Risovic

Vlatković

Popović-Pejičić

et al. 2021

Romanian Journal of Internal Medicine

View full text Add to dashboard Cite

show abstract

Plasma Homocysteine

Cited by 1 publication

References 0 publications

Relationship between serum leptin levels, non-cardiovascular risk factors and mortality in hemodialysis patients

Relationship between serum leptin levels, non-cardiovascular risk factors and mortality in hemodialysis patients

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