Plasma homocysteine: an independent or an interactive risk factor for coronary artery disease

Gupta, Mili; Sharma, Priyanka; Garg, Gitanjali; Kaur, Kiranjeet; Bedi, Gurdeep Kaur; Vij, Anil

doi:10.1016/j.cccn.2004.08.005

Cited by 15 publications

(3 citation statements)

References 19 publications

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“…A single healthy control had moderate hyperhomocysteinemia inspite of the absence of traditional risk factors. In our study, the mean homocysteine levels above which an increased risk of developing IHD was found was 16.60 µmol/L which is comparable to Gupta M et al [4] & Harish Rao B et al [5] who have reported Mean homocysteine levels as 16.57 & 18.59 in cases (our study: 16.60) & 11.47 & 11.69 in controls (our study: 10.67). The mean levels of homocysteine in patients (16.60±12.08) were almost 1.5 times that of controls (10.67±4.53).…”

Section: Study Puri a Et Al Present Studysupporting

confidence: 86%

Clinical Correlation of Serum Homocysteine Level With Lipid Profile in Coronary Artery Disease Patients

Jain¹,

Baghel²,

Jain³

et al. 2015

jemds

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Majority of patients who experience a Coronary Heart disease event have one or more of the conventional risk factors for atherosclerosis and so do many people who have not yet experienced such an event. Thus predictive models based on conventional risk factors have lower than the desired accuracy, providing a stimulus to search for new factors to predict accurately the risk of CAD. In this regard newer risk factors like homocysteine, Lp (a), insulin resistances are the important ones and are called as 'novel risk factors'. The study was undertaken to find the prediction of CAD risk by homocysteine in comparison with other conventional risk factors. The data obtained suggests a very high sensitivity, specificity and accuracy with above 90% positive prediction value for homocysteine in CAD patients when compared to commonest conventional risk factors. Treatment of hyperhomocysteinemia is cost effective in a developing country like India so early diagnosis of hyperhomocysteinemia can reduce morbidity and mortality of patient with coronary artery disease.

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Section: Study Puri a Et Al Present Studysupporting

confidence: 86%

Clinical Correlation of Serum Homocysteine Level With Lipid Profile in Coronary Artery Disease Patients

Jain¹,

Baghel²,

Jain³

et al. 2015

jemds

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“…In fact, serum cortisol concentration was found to be a predictor of homocysteine concentration together with serum folate concentration and age in a multiple regres- sion best model, indicating that the possible effect of cortisol on homocysteinemia can be separated from the effects of folate and age. An elevation in serum homocysteine concentration with age has been described previously [28] . Folate concentration has also been reported as an independent predictor of serum homocysteine concentration [14] .…”

Section: Discussionmentioning

confidence: 99%

Serum Homocysteine: Relationship with Circulating Levels of Cortisol and Ascorbate

et al. 2008

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Background/Aim: High serum levels of homocysteine and cortisol are independent risk factors for several pathologies and their levels can be regulated by some vitamins. Since the relationship between serum concentrations of homocysteine, cortisol and ascorbate has not been assessed in healthy individuals to date, it was the topic of the present work. Methods: The study group was composed of 20 men and 40 women aged >50 years. Blood samples were collected and serum concentrations of the analytes were quantified. Results: Serum homocysteine levels correlate positively with cortisol (r = 0.36, p <0.01) and age (r = 0.49, p < 0.001), and negatively with ascorbate (r = –0.30, p < 0.05) and folate (r = –0.31, p < 0.05). A negative correlation between serum levels of cortisol and ascorbate (r = –0.30, p < 0.05) was also observed. Multiple linear regression analysis showed that the best independent predictors of serum homocysteine concentration were cortisol (β = 0.319, p < 0.003), age (β = 0.529, p < 0.001) and folate (β = –0.338, p < 0.001). When subjects were divided into tertiles according to their homocysteine concentration, the highest tertile of homocysteine concentration has also higher cortisol (p < 0.005) and lower ascorbate (p < 0.05) concentrations compared with the lowest tertile of homocysteine concentration. Conclusion: The association between serum concentrations of homocysteine, cortisol and ascorbate suggests interaction between circulating levels of these molecules.

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“…Additionally, meta-analyses of clinical studies have revealed that hyperhomocysteinemia is positively associated with an increased risk of cardiovascular disease and stroke independently of other risk factors (3)(4)(5)(6). Hyperhomocysteinemia is also an independent risk factor for Alzheimer disease and dementia (7).…”

Section: Elevated Hcymentioning

confidence: 99%

Localization-independent Regulation of Homocysteine Secretion by Phosphatidylethanolamine N-Methyltransferase

Shields

Lingrell

Agellon

et al. 2005

Journal of Biological Chemistry

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Genetic ablation of phosphatidylethanolamine N-methyltransferase (PEMT) in mice causes a 50% reduction in plasma homocysteine (Hcy) levels. Because hyperhomocysteinemia is an independent risk factor for cardiovascular disease, resolution of the molecular basis for this reduction is of significant clinical interest. The PEMT pathway is a metabolically channeled process localized to the endoplasmic reticulum (ER). To assess the importance of PEMT localization for Hcy homeostasis, we identified and ablated the minimal ER targeting motif. Mutagenesis of a conserved, C-terminal lysine residue (197) relocalized the enzyme to the Golgi, demonstrating that Lys-197 is essential for targeting PEMT to the ER. To evaluate the functional significance of PEMT localization, hepatoma cell lines were generated that stably expressed either ER-or Golgi-localized PEMT only. Intriguingly, stable expression of PEMT in either the ER or the Golgi caused increased Hcy secretion. Moreover, PEMT-mediated Hcy secretion correlated with the methyltransferase activity of the enzyme, independently of subcellular localization. Thus, our data suggest that Hcy homeostasis is regulated concomitantly with PEMT activity but independently of PEMT localization.

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Plasma homocysteine: an independent or an interactive risk factor for coronary artery disease

Cited by 15 publications

References 19 publications

Clinical Correlation of Serum Homocysteine Level With Lipid Profile in Coronary Artery Disease Patients

Clinical Correlation of Serum Homocysteine Level With Lipid Profile in Coronary Artery Disease Patients

Serum Homocysteine: Relationship with Circulating Levels of Cortisol and Ascorbate

Localization-independent Regulation of Homocysteine Secretion by Phosphatidylethanolamine N-Methyltransferase

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