Plasma homocysteine and the methylenetetrahydrofolate reductase C677T gene variant

Virgos, Carmen; Martorell, Lourdes; Simó, Josep M.; Valero, Joaquı́n; Figuera, Lı́dia; Joven, Jorge; Labad, Antonio; Vilella, Elisabet

doi:10.1097/00001756-199907130-00008

Cited by 60 publications

(46 citation statements)

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“…Data for the meta-analysis were obtained from eight published case-control studies 22,[29][30][31][32][33][34][35] with a total number of 812 cases and 2113 control subjects. Figure 1 shows the ORs and 95% CIs of schizophrenia associated with a 5 mmol/l increase in measured plasma total homocysteine, separately for individual studies and for all studies when taken together.…”

Section: Homocysteine and Schizophreniamentioning

confidence: 99%

“…A total of nine published articles 22,31,33,[36][37][38][39][40][41] reported on the relationship between schizophrenia and the MTHFR 677C4T polymorphism. One article provided data on two separate studies.…”

Section: Mthfr and Schizophreniamentioning

confidence: 99%

“…Susser et al 30 Regland et al 29 Muntjewerff et al 33 Muntjewerff et al 22 Goff et al 35 Virgos et al 31 Applebaum et al 34 Levine Figure 1 Odds ratios (ORs) and 95% confidence intervals (CIs) of schizophrenia for a 5 mmol/l increase in plasma total homocysteine concentration for each study separately and combined (Studies are ordered by the inverse of the s.e. of each estimate.…”

Section: Studymentioning

confidence: 99%

“…Muntjewerff et al 33 Muntjewerff et al 22 Yu et al, Chinese series 40 Yu et al, Scottish series 40 Tan et al 41 Joober et al 38 Sazci et al 39 Virgos et al 31 Kunugi et al 37 Arinami Figure 2 Odds ratios (ORs) and 95% confidence intervals (Cls) of schizophrenia for TT versus CC genotype of the MTHFR 677C4T polymorphism of each study seperately and combined (Studies are ordered by the inverse of the s.e. of each estimate.…”

Section: Combinedmentioning

confidence: 99%

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Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis

Muntjewerff¹,

et al. 2005

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Elevated plasma homocysteine concentration has been suggested as a risk factor for schizophrenia, but the results of epidemiological studies have been inconsistent. The most extensively studied genetic variant in the homocysteine metabolism is the 677C4T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, resulting in reduced enzyme activity and, subsequently, in elevated homocysteine. A meta-analysis of eight retrospective studies (812 cases and 2113 control subjects) was carried out to examine the association between homocysteine and schizophrenia. In addition, a meta-analysis of 10 studies (2265 cases and 2721 control subjects) on the homozygous (TT) genotype of the MTHFR 677C4T polymorphism was carried out to assess if this association is causal. A 5 lmol/l higher homocysteine level was associated with a 70% (95% confidence interval, CI: 27-129) higher risk of schizophrenia. The TT genotype was associated with a 36% (95% CI: 7-72) higher risk of schizophrenia compared to the CC genotype. The performed meta-analyses showed no evidence of publication bias or excessive influence attributable to any given study. In conclusion, our study provides evidence for an association of homocysteine with schizophrenia. The elevated risk of schizophrenia associated with the homozygous genotype of the MTHFR 677C4T polymorphism provides support for causality between a disturbed homocysteine metabolism and risk of schizophrenia.

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Section: Homocysteine and Schizophreniamentioning

confidence: 99%

Section: Mthfr and Schizophreniamentioning

confidence: 99%

Section: Studymentioning

confidence: 99%

Section: Combinedmentioning

confidence: 99%

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Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis

Muntjewerff¹,

et al. 2005

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“…Later on, one study had showed that 45% of the patients of schizophrenia had higher homocysteine concentration [42]. However, Virgos et al [43] reported contradictory findings and showed that the blood homocysteine concentration was not significantly different between schizophrenia patients and normal subjects. According to previous studies, though results are not consistent, it can be assumed that hyperhomocysteinemia may be correlated to schizophrenia like psychosis to some extent.…”

Section: Discussionmentioning

confidence: 99%

Serum Homocysteine and Behavioral and Psychological Symptoms of Dementia: Is There Any Correlation in Alzheimer’s Disease?

et al. 2018

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Background: There are studies showing the relation between serum B12, folate and Behavioral and Psychological symptoms of Dementia (BPSD) in Alzheimer’s disease (AD). Serum levels of these vitamins do not reflect actual disease status and therefore checking the serum Homocysteine level is considered a better test. Homocysteine has been found to be associated with cognitive impairment and various psychiatric disorders. Purpose: This study was planned to identify the correlation between serum homocysteine levels and BPSD in AD patients. Methods: AD patients (n = 18) and healthy controls (n = 18) were included in the study. Diagnosis of AD was confirmed using International Classification Disease-10. AD patients were assessed using Mini Mental Status Examination (MMSE), Clinical Dementia Rating scale (CDR), Global Deterioration scale (GDS), and Neuropsychiatric inventory (NPI). Healthy controls were assessed on MMSE and Mini International Neuropsychiatric Interview. Serum homocysteine, vitamin B12, and folate levels were measured in all study subjects. Results: Patients with AD had statistically significant higher serum levels of homocysteine as compared to the control group, while the levels of vitamin B12 and folate did not differ significantly. There was statistically significant positive correlation of serum homocysteine levels with total NPI score as well as with NPI sub-domains particularly delusion, agitation/aggression, and depression/dysphoria. Serum homocysteine levels did not correlate significantly with MMSE, CDR, and GDS scores. Conclusion: Correlation was observed between serum homocysteine levels and behavioral and psychological symptoms of AD. There is a possibility of etiological role, but the underlying pathophysiological mechanisms need to be elucidated. Whether patients will benefit or not with supplements of vitamin B12 and folate requires further research. This was a cross-sectional study and findings should not be generalized. Further prospective longitudinal studies with a large number of patients are needed.

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Elevated Prenatal Homocysteine Levels as a Risk Factor for Schizophrenia

Brown¹,

Bottiglieri²,

Schaefer³

et al. 2007

Arch Gen Psychiatry

143

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These findings indicate that elevated third-trimester homocysteine levels may be a risk factor for schizophrenia. Elevated third-trimester homocysteine levels may elevate schizophrenia risk through developmental effects on brain structure and function and/or through subtle damage to the placental vasculature that compromises oxygen delivery to the fetus. If future studies both replicate this association and support a causal link, then the use of folic acid supplementation would merit evaluation as a strategy for prevention of schizophrenia in offspring.

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Plasma homocysteine and the methylenetetrahydrofolate reductase C677T gene variant

Cited by 60 publications

References 1 publication

Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis

Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis

Serum Homocysteine and Behavioral and Psychological Symptoms of Dementia: Is There Any Correlation in Alzheimer’s Disease?

Elevated Prenatal Homocysteine Levels as a Risk Factor for Schizophrenia

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