Plasma Homocysteine, Folate and Vitamin B₁₂ in Different Trimester of Pregnancy

Abstract

Abstract:The present study has been undertaken to investigate plasma creatinine, folate and vitamin B 12 as underlying factors in the reduction of plasma homocysteine concentration in different trimesters of pregnancy. Under a cross-sectional design, 30 healthy nonpregnant as well as 130 pregnant women, at 3 different trimesters of pregnancy (43 in 1 st trimester, 44 in 2 nd trimester and 43 in 3 rd trimester) were sampled for plasma levels of folate, vitamin B 12, homocysteine and creatinine. Plasma homocysteine and creatinine level were significantly (p<0.014) lower in pregnant women at different trimester (1 st , 2 nd and 3 rd trimester) compared to nonpregnant women. Plasma folate was significantly higher in different groups of pregnant women compared to nonpregnant women. Significant negative correlation was found between plasma homocysteine and folate in nonpregnant (r=-0.453, p<0.012) and pregnant women at 2 nd trimester (r=-0.681, p<0.001). There was found significant negative correlation between plasma homocysteine and vitamin B 12 at 1 st trimester group (r=-0.322, p<0.035) and 2 nd trimester group (r=-0.394, p<0.008) but not in 3 rd trimester. In present study, reduction of plasma total homocysteine appears to be a physiological response in pregnancy, and the level of plasma folate and vitamin B 12 , but can not be explained by renal homodynamic changes.

Association between Decreased Plasma Folate Levels and MTHFR C677T, and MTRR A66G Gene Polymorphisms as Determinants for Elevated Total Homocysteine Concentrations in Pregnant Women

“…Although both plasma folate and tHcy levels are significantly different in pregnant women than non-pregnancy women [48], no statistical significances were observed between first trimester and second trimester with plasma folate and tHcy levels. No previous study has investigated the relationship between plasma folate levels tendency and gestational weeks.…”

The length of AZT consumption and homocysteine levels are protective factors of macrocytic anemia among adult HIV-infected patients: A case-control study in Central Java Province, Indonesia

“…Folate also plays an important role in two biochemical cycles, which are biosynthesis DNA and carbon metabolism such as DNA, lipid, and protein methylation. 24,25 The average Hcy levels in subjects with macrocytic anemia (case group) were10,2±5,5 µmol/L. Meanwhile, the average Hcy levels in subjects without anemia (control group) was 12,9±8,2 µmol/L.…”

“…Folate also plays an important part in two biochemical cycles, which are DNA biosynthesis and carbon metabolisms such as DNA, lipid, and protein methylation. 24,25 Up until now, several researchers had studied how Hcy levels can affect HIV patients, but the results were controversial. Look et al found hyperhomocysteinemia (HHcy) in 35% of HIV patients who received HAART.…”