2020
DOI: 10.2478/prilozi-2020-0019
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Plasma Homocysteine in Patients with Coronary and Carotid Artery Disease: A Case Control Study

Abstract: AbstractIntroduction: Homocystein (Hcy) is an amino acid and elevated plasma cause endothelial damage, followed with inflammation in the blood vessels and its progression in atherosclerosis. We aimed to evaluate the correlation between cardiovascular disease and serum homocysteine levels..Methods: We performed a case control analysis of 212 patients, either for cardiovascular risk stratification or for invasive diag… Show more

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Cited by 7 publications
(6 citation statements)
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References 18 publications
(17 reference statements)
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“…The regression analysis also maintained significance of disease with family history (p < 0.001, OR 1.341) but not with diabetes mellitus. Elevated homocysteine level is novel, independent risk factor of atherosclerotic vascular disease affecting many vascular beds such as peripheral, carotid and coronary vasculature, [2,17,22,35] the higher homocysteine levels being positively related to fatal outcomes [36]. The current study was consistent with previous literature, as both analyses maintained statistical significance of homocysteine with CAD.…”
Section: Factorssupporting
confidence: 90%
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“…The regression analysis also maintained significance of disease with family history (p < 0.001, OR 1.341) but not with diabetes mellitus. Elevated homocysteine level is novel, independent risk factor of atherosclerotic vascular disease affecting many vascular beds such as peripheral, carotid and coronary vasculature, [2,17,22,35] the higher homocysteine levels being positively related to fatal outcomes [36]. The current study was consistent with previous literature, as both analyses maintained statistical significance of homocysteine with CAD.…”
Section: Factorssupporting
confidence: 90%
“…This affiliation warranted studying the polymorphism but the current study was unable to associate it with CAD. The important predictors of CAD including the traditional risk factors such as cholesterol, and family history of CAD; the novel serum parameter homocysteine; and genetic polymorphisms in MTHFR gene, altogether are robustly allied to CAD in previous literature [17,33,40,50,51]. These parameters, in essence, achieved statistical significance with CAD in current study.…”
Section: Factorsmentioning
confidence: 51%
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“…Our study also highlights the role of Hcy, a small amino acid that was involved in vital processes such as energy metabolism and methylation [45], in the process of stress-induced cognitive dysfunction in mice.…”
Section: Discussionmentioning
confidence: 58%