Plasma Homocysteine Levels Are Associated With Circadian Blood Pressure Variation in Chinese Hypertensive Adults

Yan, Dong; Zhan, Biming; Hao, Qing-Yun; Ruan, Zhao-Hui; Xu, Zixuan; Deng, Ming; Chen, Dawei; Zou, Yeqing; Chen, Jing; Li, Ping

doi:10.1093/ajh/hpx116

Cited by 12 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Differences between these studies might be explained by the participants’ ethnicities. Total plasma Hcy levels have significant gender‐dependent differences although the conclusions of the previous studies were conflicting …”

Section: Discussionsupporting

confidence: 90%

Association between plasma homocysteine and hypertension: Results from a cross‐sectional and longitudinal analysis in Beijing’s adult population from 2012 to 2017

Tao

Yang

et al. 2018

J of Clinical Hypertension

View full text Add to dashboard Cite

D141100000114003). All funding sources were independent and had no influence on the study design, the collection, analysis, and interpretation of our data, the writing of this report, or the decision to submit the article for publication. Plasma homocysteine (Hcy) levels are associated with elevated blood pressure.However, the causal association between Hcy levels and the risk of hypertension remains ambiguous. Taking the study design effect into consideration, this study aimed to investigate this issue through a cross-sectional and longitudinal analysis.Data were obtained from the Beijing Health Management Cohort study, which conducted routine health check-ups from 2012 to 2017. Multivariate logistic regression was used for the cross-sectional analysis, and a quadratic inference function approach was performed for the longitudinal analysis. A total of 30 376 subjects (mean age = 50.0 years) were included in the cross-sectional analysis, and a subgroup of 3913 subjects without hypertension at baseline was included in the longitudinal analysis. After adjusting for potential confounders, the risk of hypertension increased with Hcy levels in the cross-sectional analysis using the traditional definition of hypertension (OR = 1.262, 95% CI: 1.155-1.378, Q2 vs Q1; OR = 1.458, 95% CI:1.335-1.593, Q3 vs Q1; OR = 1.520, 95% CI: 1.388-1.664, Q4 vs Q1) and the 2017 hypertension definition (OR = 1.159, 95% CI: 1.067-1.259, Q2 vs Q1; OR = 1.328, 95% CI: 1.221-1.445, Q3 vs Q1; OR = 1.328, 95% CI: 1.217-1.449, Q4 vs Q1). The longitudinal analysis showed that hypertension risk increased in the third quartile of Hcy (OR = 1.268, 95% CI: 1.030-1.560, Q3 vs Q1). Elevated total plasma Hcy may be used as a predictive biomarker for hypertension. Attention should be paid to genderspecific mechanisms when issuing precise precautions. | 1625TAO eT Al.

show abstract

Section: Discussionsupporting

confidence: 90%

Association between plasma homocysteine and hypertension: Results from a cross‐sectional and longitudinal analysis in Beijing’s adult population from 2012 to 2017

Tao

Yang

et al. 2018

J of Clinical Hypertension

View full text Add to dashboard Cite

show abstract

“…Investigators have reported a significant association of serum Hcy with different indices of arterial stiffness such as pulse pressure and aortic stiffness in the general population 4 and in elderly patients who have multiple cardiovascular risk factors 7 . Moreover, Hcy was associated with non‐dipping BP pattern, a potent predictor of cardiovascular mortality and morbidity in hypertensive individuals 8 . Plasma Hcy concentrations correlated with the incidence of cardiovascular, cerebrovascular, and peripheral artery disease 9 and atherosclerotic vascular damage 10 .…”

Section: Introductionmentioning

confidence: 99%

“…7 Moreover, Hcy was associated with non‐dipping BP pattern, a potent predictor of cardiovascular mortality and morbidity in hypertensive individuals. 8 Plasma Hcy concentrations correlated with the incidence of cardiovascular, cerebrovascular, and peripheral artery disease 9 and atherosclerotic vascular damage. 10 In addition, hyper‐homocysteinemia (hHcy) was associated with peripheral microvascular endothelial dysfunction and a Hcy level of >10 µmol/L was significantly associated with all‐cause mortality and atherosclerotic cardiovascular events in older obese and hypertensive patients.…”

Section: Introductionmentioning

confidence: 99%

Homocysteine predicts vascular target organ damage in hypertension and may serve as guidance for first‐line antihypertensive therapy

Carnagarin

Nolde

Ward

et al. 2021

J of Clinical Hypertension

View full text Add to dashboard Cite

Homocysteine is an independent risk factor for cardiovascular and cerebrovascular disease and has been proposed to contribute to vascular dysfunction. We sought to determine in a real‐world clinical setting whether homocysteine levels were associated with hypertension mediated organ damage (HMOD) and could guide treatment choices in hypertension. We performed a cross‐sectional analysis of prospectively collected data in 145 hypertensive patients referred to our tertiary hypertension clinic at Royal Perth Hospital and analyzed the association of homocysteine with HMOD, renin‐angiotensin‐aldosterone system (RAAS), and RAAS blockade. The average age of participants was 56 ± 17 years, and there was a greater proportion of males than females (89 vs. 56). Regression analysis showed that homocysteine was significantly associated with PWV (β = 1.99; 95% CI 0.99‐3.0; p < .001), albumin‐creatinine ratio (lnACR: β = 1.14; 95% CI 0.47, 1.8; p < .001), 24 h urinary protein excretion (β = 0.7; 95% CI 0.48, 0.92; p < .001), and estimated glomerular filtration rate (β = −29.4; 95% CI −36.35, −22.4; p < .001), which persisted after adjusting for potential confounders such as age, sex, 24 h BP, inflammation, smoking, diabetes mellitus (DM), and dyslipidemia. A positive predictive relationship was observed between plasma homocysteine levels and PWV, with every 1.0 µmol/L increase in homocysteine associated with a 0.1 m/s increase in PWV. Homocysteine was significantly associated with elevated aldosterone concentration (β = 0.26; p < .001), and with attenuation of ACEi mediated systolic BP lowering and regression of HMOD compared to angiotensin receptor blockers in higher physiological ranges of homocysteine. Our results indicate that homocysteine is associated with hypertension mediated vascular damage and could potentially serve to guide first‐line antihypertensive therapy.

show abstract

“…The results of these studies have been confirmed in the work of Dong Yi-Fey et al [61]. These authors randomly selected 244 patients with normal nighttime blood pressure drop (blood pressure drop greater than 10%, dippers) and 249 patients with abnormal nighttime blood pressure drop (nondippers) from 5,223 hypertensive patients.…”

Section: Homocysteine and Night-time Blood Pressure Dropmentioning

confidence: 61%

The significance of homocysteine in patients with hypertension

Głuszek¹,

Kosicka

2021

Postępy Higieny I Medycyny Doświadczalnej

View full text Add to dashboard Cite

Cardiovascular disease is the most common cause of death in developed countries. Important factors leading to ischemic heart disease and strokes are hypertension and high levels of homocysteine in blood serum. The coexistence of these two factors significantly increases the risk of these diseases and premature deaths. Many studies indicate that patients with hypertension are significantly more likely to demonstrate increased blood serum homocysteine levels than those with normal blood pressure. This may be caused by a higher incidence of overweight, high intake of salt and increased uric acid levels. It has been shown that both these factors increase the prevalence of hypertension and lead to higher homocysteine levels. However, the results of some studies indicate that arterial hypertension and homocysteinemia are causally related. It was shown, among other things, that high homocysteine levels damage the endothelium and reduce nitric oxide synthesis, which may directly lead to hypertension. Serum homocysteine levels are slightly higher in patients with white coat hypertension than they are in healthy individuals and may therefore also increase the risk of cardiovascular diseases. Several authors have also shown that the levels of homocysteine in blood serum are higher in so-called non-dippers, i.e., patients with no night-time pressure drop. The lack of a 10%–20% decrease in blood pressure at night is associated with increased cardiovascular complications. Strokes occur especially frequently in older people with arterial hypertension and hyperhomocysteinemia. The administration of B vitamins and folic acid significantly reduces serum homocysteine levels. The administration of this acid also slightly, but statistically significantly, increases the effectiveness of hypotensive drugs. Large meta-analyses meta-analysis indicate that the increased supply of folic acid in patients with hypertension significantly reduces the risk of stroke. Such management is particularly effective in patients with hypertension and hyperhomocysteinemia.

show abstract

Plasma Homocysteine Levels Are Associated With Circadian Blood Pressure Variation in Chinese Hypertensive Adults

Abstract: These results indicated that high homocysteine levels associate with disturbed circadian BP variation in Chinese hypertensive adults.

Cited by 12 publications

References 30 publications

Association between plasma homocysteine and hypertension: Results from a cross‐sectional and longitudinal analysis in Beijing’s adult population from 2012 to 2017

Association between plasma homocysteine and hypertension: Results from a cross‐sectional and longitudinal analysis in Beijing’s adult population from 2012 to 2017

Homocysteine predicts vascular target organ damage in hypertension and may serve as guidance for first‐line antihypertensive therapy

The significance of homocysteine in patients with hypertension

Contact Info

Product

Resources

About