Plasma hormones and lipids in men at different risk for coronary heart disease

Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County

“…Hill and Wynder (1979) reported a significant reduction in plasma testosterone concentration after changing over from a western diet with 40% of energy from fat to a vegetarian diet with 25% of energy from fat. However, in a subsequent paper (Hill et al, 1980) The method of risk quantification used in this study assumes that the age-adjusted incidence of cancer at all other sites combined is relatively constant over the subsets of interest. A rough test of the validity of this assumption is the race-specific comparison of age-adjusted all-site incidence in Los Angeles with that in homelands.…”

The effects of diet on circulating sex hormone levels in men

“…A large reduction in total fat (from 40 to 25 % energy intake) was associated with a signi®cant fall in plasma cholesterol concentration among the black Americans, and signi®cant reductions in plasma testosterone concentration in both the black and white Americans (Hill et al 1980). Although the change to a Western diet was associated with a signi®cant increase in cholesterol concentration in the black South African men, it was also associated with a signi®cant fall in testosterone concentration (Hill et al 1980), an observation that was repeated in a later study (Hill et al 1982). Neither study found oestradiol concentration to be signi®cantly affected by diet, although oestrone concentration was substantially higher following the high-fat regimen (Hill et al 1982).…”

Longitudinal Relationships among Endogenous Testosterone, Estradiol, and Quetelet Index with High and Low Density Lipoprotein Cholesterols in Adolescent Boys

“…The overall pattern of change of HDLC and LDLC during sexual maturation in boys can be associated with changes in testosterone, estradiol, and Quetelet index. Abbreviations E2, estradiol HDLC, high density lipoprotein cholesterol LDLC, low density lipoprotein cholesterol Q, Quetelet index T, testosterone TG, triglycerideThe decrement in HDLC during male adolescence has been postulated to result from increased T production (16, 18); however, there is a significant positive correlation between HDLC and T in adult men (13,15,25,30). In adults, pharmacologic doses of exogenous T lower HDLC (2, 11).…”

“…The adult male-female differences in lipoproteins (lower HDLC, higher LDLC, and higher TG) probably account, in part, for male-premenopausal female differences in atherosclerosis (32,33,36). Understanding of the physiologic events during male adolescence (5,26) that lead to a decrement in HDLC and to an apparent inverse relationship between T and HDLC (16, 18), has considerable physiologic importance, particularly because after sexual maturation, in adult men, T is positively related to HDLC (13,15,25,30).To examine the physiology of changes in LDLC, HDLC, TG, rapid physical growth, and sexual maturation, the Princeton School Maturation Study was initiated in 1976 (29). A randomly selected sub-group of the Princeton Prevalence Program was drawn (27-297, and annual measurements of lipids, lipoproteins, blood pressure, and physical growth were made in conjunction with assessments of sexual maturation as indicated by the Tanner Scale (23,24).…”