Plasma human neutrophil proteins-1, -2, and -3 levels in patients with bladder cancer

Güneş, Mustafa; Geçit, İlhan; Pirinççi, Necip; Kemik, Ahu Sarbay; Pürisa, Sevim; Ceylan, Kadir; Aslan, Mehmet

doi:10.1007/s00432-012-1305-0

Cited by 20 publications

(15 citation statements)

References 13 publications

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“…[43] found that patients with bladder cancer have increased levels of 3 neutrophil proteins, human neutrophil protein-1, -2, and -3 (HNP 1–3). All three HNPs are subtypes of α-defensins, proteins that aid in the recruitment of leukocytes and might contribute to metastasis.…”

Section: Neutrophilsmentioning

confidence: 99%

“…This may be accomplished as a result of HNPs promoting cytokine release, stimulating monocytes, and inhibiting the fibrinolytic system. The HNPs found in cancer cells are primarily derived from tumor invading neutrophils and eosinophils [43,44]. Gunes and colleagues [43] found that the levels of all three HNPs were overexpressed in the plasma of the tested bladder cancer patient population, potentially due to neutrophil damage (n=30).…”

Section: Neutrophilsmentioning

confidence: 99%

“…The HNPs found in cancer cells are primarily derived from tumor invading neutrophils and eosinophils [43,44]. Gunes and colleagues [43] found that the levels of all three HNPs were overexpressed in the plasma of the tested bladder cancer patient population, potentially due to neutrophil damage (n=30). Additionally, Vlahou et al [45] found elevated levels of HNPs 1–3 in the urine of bladder cancer patients.…”

Section: Neutrophilsmentioning

confidence: 99%

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Immunological basis in the pathogenesis and treatment of bladder cancer

Thompson

Siref

Feloney

et al. 2014

Expert Review of Clinical Immunology

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The pathogenesis and transition of normal urothelium into bladder carcinoma are multifactorial processes. Chronic inflammation causes initiation and progression of the underlying pathophysiology of invasive and metastatic cancer. A dichotomy is observed in the role of immune cells in bladder cancer. While the immune response defends the host by suppressing neoplastic growth, several immune cells, including neutrophils, macrophages, and T-lymphocytes, promote tumor development and progression. The levels of human neutrophil peptide-1, -2, and -3, produced by neutrophils, increase in bladder cancer and might promote tumor angiogenesis and growth. The effect of macrophages is primarily mediated by pro-inflammatory cytokines, IL-6 and TNF-α. Additionally, the underlying immunological mechanisms of two treatments, BCG and cytokine gene-modified tumor vaccines, and future directions are critically discussed.

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Section: Neutrophilsmentioning

confidence: 99%

Section: Neutrophilsmentioning

confidence: 99%

Section: Neutrophilsmentioning

confidence: 99%

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Immunological basis in the pathogenesis and treatment of bladder cancer

Thompson

Siref

Feloney

et al. 2014

Expert Review of Clinical Immunology

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“…Reduced defensin levels have been observed in the congenital disease “specific granule deficiency,” acquired defensin deficiencies occasionally in patients with chronic myelogenous leukemia, associated with an increased risk for infections caused by common bacteria . Stimulated expression of α‐defensins is obviously not exclusively associated with microbial infections, but also, for example, with active autoimmune diseases, acute coronary artery disease, or progredient cancer . In our study, some HD patients had a history of autoimmune disease (2 patients with lupus erythematosus), confirmed coronary heart disease (19 patients), or cancer (condition after cancer of the kidney [5], prostate [4], skin [2], breast [1], colon [2]), but at the time of the study all were on stable conditions.…”

Section: Discussionmentioning

confidence: 64%

“…17 Stimulated expression of α-defensins is obviously not exclusively associated with microbial infections, but also, for example, with active autoimmune diseases, 18 acute coronary artery disease, 19 or progredient cancer. 20 In our study, some HD patients had a history of autoimmune disease (2 patients with lupus erythematosus), confirmed coronary heart disease (19 patients), or cancer (condition after cancer of the kidney [5], prostate [4], skin [2], breast [1], colon [2]), but at the time of the study all were on stable conditions. We observed for none of these diagnoses in periods free of infection a significantly increased α-defensin expression compared with the other patients (data not shown).…”

Section: Figurementioning

confidence: 77%

Impaired immune defense in hemodialysis patients: Role of α‐defensins?

Grupp

Troche-Polzien

Noeding

et al. 2013

Hemodialysis International

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The mechanisms underlying the impaired immune response in hemodialysis (HD) patients are not completely understood. The α-defensins human neutrophil peptides-1, 2, and 3 are low molecular weight peptides with antimicrobial activity and important effector molecules of innate immune responses. We now examined the expression of these peptides in HD patients. Seventy-six patients on chronic HD treatment (mean time on HD 5.8 years; mean age 70 years) were studied and compared with 38 healthy volunteers and 20 patients with infections and normal renal function. Expression of α-defensins was analyzed semiquantitatively in leukocytes on the messenger RNA (mRNA) level by reverse transcriptase polymerase chain reaction; the α-defensin protein levels in serum were detected by enzyme-linked immunosorbent assay. α-Defensin concentrations (140 ± 10.5 ng/mL; mean ± standard error of the mean) as well as mRNA levels in leukocytes (82.9 ± 7.9 arbitrary units [a.u.]) in HD patients were not significantly different from those in healthy volunteers (156 ± 15.2 ng/mL; 81.4 ± 11.3 a.u.). Defensin levels were independent of the time of the patient on HD and their age. During infection periods (mean increase of the C-reactive protein to 161 ± 17.3 mg/L), defensin serum levels increased to 321 ± 65 ng/mL (P < 0.005) and mRNA expression in leukocytes to 159 ± 19.2 a.u. (P < 0.05). These increases were not significantly different from those in patients with normal renal function (298 ± 46.8 ng/mL and 128 ± 9.1 a.u., respectively) suffering from infections (C-reactive protein 222 ± 26.6 mg/L). Our results suggest that the impaired immune defense in dialysis patients is not due to a deficiency in α-defensins in these patients as neither basal levels nor expression during infections were reduced compared with subjects with normal renal function.

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An Overview of Angiogenesis in Bladder Cancer

2023

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Purpose of the Review Angiogenesis plays a key role in bladder cancer (BC) pathogenesis. In the last two decades, an increasing number of publications depicting a multitude of novel angiogenic molecules and pathways have emerged. The growing complexity necessitates an evaluation of the breadth of current knowledge to highlight key findings and guide future research. Recent Findings Angiogenesis is a dynamic biologic process that is inherently difficult to assess. Clinical assessment of angiogenesis in BCs is advancing with the integration of image analysis systems and dynamic contrast-enhanced and magnetic resonance imaging (DCE-MRI). Tumour-associated macrophages (TAMs) significantly influence the angiogenic process, and further research is needed to assess their potential as therapeutic targets. A rapidly growing list of non-coding RNAs affect angiogenesis in BCs, partly through modulation of vascular endothelial growth factor (VEGF) activity. Vascular mimicry (VM) has been repeatedly associated with increased tumour aggressiveness in BCs. Standardised assays are needed for appropriate identification and quantification of VM channels. Summary This article demonstrates the dynamic and complex nature of the angiogenic process and asserts the need for further studies to deepen our understanding.

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Plasma human neutrophil proteins-1, -2, and -3 levels in patients with bladder cancer

Abstract: The preoperative plasma levels of HNPs 1-3 paralleled the progression and pathological stages of the malignancies. This study suggests that HNPs 1-3 promote tumor invasion and are potential indicators of disease progression in patients with bladder cancer.

Cited by 20 publications

References 13 publications

Immunological basis in the pathogenesis and treatment of bladder cancer

Immunological basis in the pathogenesis and treatment of bladder cancer

Impaired immune defense in hemodialysis patients: Role of α‐defensins?

An Overview of Angiogenesis in Bladder Cancer

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