Plasma hyaluronan and collateral development in patients with coronary artery disease

Xi, Weiwei; Zhou, Ying; Lv, Shumin; Gao, Qingzhu; Bu, Gang; Wang, Yuxing; Cheng, Gang; Xu, Geng

doi:10.1097/mca.0b013e328338ccf3

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…A significant positive correlation was found between HA levels and glycemia in our study population. Our findings were in line with previous studies, also reporting a critical role for HA in DM-related atherosclerosis ( 26 – 29 , 65 ). In vascular dysfunction, HA triggers smooth muscle cells’ dedifferentiation, which contributes to vessel wall thickening.…”

Section: Discussionsupporting

confidence: 94%

In Vivo and In Vitro Analysis in Coronary Artery Disease Related to Type 2 Diabetes

et al. 2017

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AimThe leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (DM) is coronary artery disease (CAD), a condition often asymptomatic but severe in these patients. Although glucose metabolism impairment and oxidative stress are known actors in the endothelial dysfunction/remodeling that occurs in diabetic patients, the relationship between cardiovascular disorders and DM is not fully understood. We have performed both an in vivo imaging and in vitro molecular analysis to investigate diabetic-specific CAD alterations.MethodsComputed tomography coronary angiography (CTCA) was performed in a group of 20 diabetic patients with CAD (DM+CAD+), 20 non-diabetic with CAD (DM−CAD+), 10 diabetic non-CAD patients (DM+CAD−), and 20 non-diabetic healthy subjects (HS). Imaging quantitative parameters such as calcium score (Cascore), calcified plaque volume (CPV), non-calcified plaque volume (NCPV), total plaque volume (TPV), remodeling index (RI), and plaque burden were extracted for each CAD subject. Moreover, the expression levels of superoxide dismutase 2 (SOD2) and liver X receptor alpha (LXRα) genes were analyzed in the peripheral blood mononuclear cells, whereas hyaluronan (HA) concentrations were evaluated in the plasma of each subject.ResultsImaging parameters, such as Cascore, CPV, RI, and plaque burden, were significantly higher in DM+CAD+ group, compared to DM−CAD+ (P = 0.019; P = 0.014; P < 0.001, P < 0.001, respectively). SOD2 mRNA was downregulated, while LXRα gene expression was upregulated in DM+CAD−, DM+CAD+, and DM−CAD+ groups compared to HS (P = 0.001, P = 0.03, and P = 0.001 for SOD2 and P = 0.006, P = 0.008, and P < 0.001 for LXRα, respectively). Plasmatic levels of HA were higher in DM−CAD+, DM+CAD−, and DM+CAD+ groups, compared to HS (P = 0.001 for the three groups). When compared to DM−CAD+, HA concentration was higher in DM+CAD− (P = 0.008) and DM+CAD+ (P < 0.001) with a significant difference between the two diabetic groups (P = 0.003). Moreover, HA showed a significant association with diabetes (P = 0.01) in the study population, and the correlation between HA levels and glycemia was statistically significant (ρ = 0.73, P < 0.001).ConclusionIn our population, imaging parameters highlight a greater severity of CAD in diabetic patients. Among molecular parameters, HA is modulated by diabetic CAD-related alterations while SOD2 and LXRα are found to be more associated with CAD but do not discriminate between diabetic and non-diabetic subgroups.

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Section: Discussionsupporting

confidence: 94%

In Vivo and In Vitro Analysis in Coronary Artery Disease Related to Type 2 Diabetes

et al. 2017

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“…These data support the concept that a systemic inflammatory process may enhance the production of HA and trigger the associated immune responses. Elevated plasma HA has been found to be a marker for the extent of collateral formation in patients with coronary artery disease [42]. Furthermore, in our study, IS patients had a higher percentage of medical treatment for diabetes mellitus but not for hypertension and hyperlipidemia than ICH patients.…”

Section: Discussionsupporting

confidence: 44%

Association between plasma levels of hyaluronic acid and functional outcome in acute stroke patients

Tang

Yeh

Tsai

et al. 2014

J Neuroinflammation

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BackgroundActivation of hyaluronic acid (HA) and associated enzyme synthesis has been demonstrated in experimental stroke animal models. Our study aimed to investigate the plasma levels of HA in acute stroke patients and the associations between HA levels and functional outcome.MethodsThis was a multicenter case–control study. Acute stroke patients and age- and sex-matched non-stroke controls were recruited. Plasma levels of HA in acute stroke patients were determined at <48 hours and at 48 to 72 hours after stroke onset by standard ELISA. Favorable functional outcome was defined as modified Rankin scale ≤2 at 3 months after stroke.ResultsThe study included 206 acute stroke patients, including 43 who had intracerebral hemorrhage and 163 who had ischemic stroke, and 159 controls. The plasma levels of HA in the acute stroke patients were significantly higher than those in the controls (219.7 ± 203.4 ng/ml for <48 hours and 343.1 ± 710.3 ng/ml for 48 to 72 hours versus 170.4 ± 127.9 ng/ml in the controls; both P < 0.05). For intracerebral hemorrhage patients, HA ≤500 ng/ml (<48 hours) was an independent favorable outcome predictor (P = 0.016). For ischemic stroke patients, an inverted U-shaped association between plasma HA (48 to 72 hours) and outcome was noted, indicating that ischemic stroke patients with too high or too low plasma HA levels tended to have an unfavorable outcome.ConclusionHA plasma level was elevated in patients with acute stroke, and can predict 3-month functional outcome, particularly for patients with intracerebral hemorrhage.

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“…The mechanism of HA-induced angiogenesis involves the receptor for HA-mediated motility (RHAMM) and TGF-β receptor I (TGFBRI) [Park et al 2012]. It has been demonstrated that the plasmatic HA level is associated with a significant enhancement in coronary collateralization, suggesting that circulating HA could also promote angiogenesis [Xi et al 2010]. This should be considered along with the recent discovery that HA degradation generates small oligosaccharides that are able to increase pro-inflammatory (IL-1, TNFα) and pro-angiogenic cytokines (IL-18) production by synovial fibroblasts (RASF) obtained from mice subjected to collagen induced arthritis (CIA) [Campo et al 2012a[Campo et al , 2012b.…”

Section: Hyaluronic Acidmentioning

confidence: 99%

Targeting the synovial angiogenesis as a novel treatment approach to osteoarthritis

Henrotin

Pesesse

Lambert

2013

Therapeutic Advances in Musculoskeletal

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Synovitis is a key feature in osteoarthritis and is associated with symptom severity. Synovial membrane inflammation is secondary to cartilage degradation which occurs in the early stage and is located adjacent to cartilage damage. This inflammation is characterized by the invasion and activation of macrophages and lymphocytes, the release in the joint cavity of large amounts of pro-inflammatory and procatabolic mediators, and by a local increase of synovial membrane vascularity. This latter process plays an important role in the chronicity of the inflammatory reaction by facilitating the invasion of the synovium by immune cells. Therefore, synovial membrane angiogenesis represents a key target for the treatment of osteoarthritis. This paper is a narrative review of the literature referenced in PubMed during the past 5 years. It addresses in particular three questions. What are the mechanisms involved in synovium blood vessels invasion? Are current medications effective in controlling blood vessels formation and invasion? What are the perspectives of research in this area?

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Plasma hyaluronan and collateral development in patients with coronary artery disease

Abstract: This study suggests that elevated plasma HA levels are associated with a significant enhancement in coronary collateralization. HA may serve as a novel potential biomarker for collateral formation in patients with coronary artery disease.

Cited by 3 publications

References 21 publications

In Vivo and In Vitro Analysis in Coronary Artery Disease Related to Type 2 Diabetes

In Vivo and In Vitro Analysis in Coronary Artery Disease Related to Type 2 Diabetes

Association between plasma levels of hyaluronic acid and functional outcome in acute stroke patients

Targeting the synovial angiogenesis as a novel treatment approach to osteoarthritis

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