Plasma in cancer treatment

Schlegel, Jürgen; Köritzer, Julia; Boxhammer, Veronika

doi:10.1016/j.cpme.2013.08.001

Cited by 282 publications

(198 citation statements)

References 42 publications

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“…To evaluate LB, the experienced refractive indices along the x and y-axes are calculated using equation (5). The induced anisotropy terms ∆η are assumed to be small enough to allow a Taylor expansion, see equations (7) and (8).…”

Section: Externally Induced Birefringencementioning

confidence: 99%

“…Because plasma jets are non-thermal, two of the most rapidly growing fields are surface functionalization [1] and plasma medicine [2] to treat e.g. various biomedical surfaces [3][4][5]. In order to understand what is happening in the treated sample and how the discharges are produced by the plasma jet, it is important to have various diagnostic tools available.…”

Section: Introductionmentioning

confidence: 99%

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Electric field and temperature in a target induced by a plasma jet imaged using Mueller polarimetry

Slikboer

Sobota

Guaitella

et al. 2017

J. Phys. D: Appl. Phys.

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Mueller polarimetry is used to investigate the behavior of an electro optic target (BSO crystal) under exposure of guided ionization waves produced by an atmospheric pressure plasma jet. For the first time, this optical technique is time resolved to obtain the complete Mueller matrix of the sample right before and after the impact of the discharges. By analyzing the induced birefringence, the spatial profiles and local values are obtained of both the electric field and temperature in the sample. Electric fields are generated due to deposited surface charges and a temperature profile is present, due to the heat transferred by the plasma jet. The study of electric field dynamics and local temperature increase at the target, due to the plasma jet is important for biomedical applications, as well as surface functionalization. This work shows how Mueller polarimetry can be used as a novel diagnostic to simultaneously acquire the spatial distribution and local values of both the electric field and temperature, by coupling the external source of anisotropy to the measured induced birefringence via the symmetry point group of the examined material.

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Section: Externally Induced Birefringencementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electric field and temperature in a target induced by a plasma jet imaged using Mueller polarimetry

Slikboer

Sobota

Guaitella

et al. 2017

J. Phys. D: Appl. Phys.

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“…APP formed in air generates reactive oxygen (ROS) and nitrogen species (RNS). These species appear to induce cell cycle arrest at relatively low plasma "doses", lead to apoptosis at higher doses 4 , and ultimately cause necrosis at the highest doses 5 . Furthermore, a remarkable similarity of anti-tumor action for all types of cancers investigated was observed:…”

Section: Introductionmentioning

confidence: 99%

Plasma-induced selectivity in bone cancer cells death

Canal

Fontelo

Hamouda

et al. 2017

Free Radical Biology and Medicine

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“…Utjecaj tretmana CAP-om na stanice tumora intenzivno se istražuje, što je rezultiralo velikim brojem studija u kojima su korišteni različiti izvori CAP-a i mnogobrojne stanič-ne linije izvedene iz različitih tumorskih tkiva 42,43 . Iako mehanizmi učinka tretmana CAP-om na stanice tumora još uvijek nisu u potpunosti razjašnjeni, treba istaknuti nekoliko osnovnih zaključaka/rezultata dosadašnjih studija: 1. tretman CAP-om rezultira povećanom koncentracijom intracelularnih ROS [50][51][52][53] .…”

Section: Moguća Primjena U Terapiji Tumoraunclassified

Plasma applications in medicine and dentistry

Mance

2017

Med. flum.

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Sažetak. U fizici, plazma je ioniziran, kvazineutralan plin za koji se često kaže da je četvrto stanje materije. Dugo vremena se plazma u medicini koristila zbog svojih termalnih svojstava, primjerice za sterilizaciju kirurškog i medicinskog pribora te za rezanje i kauterizaciju tkiva. Generiranjem hladne plazme u atmosferskim uvjetima započelo je novo razdoblje u primjeni plazme u biomedicini. Plazma medicina novo je interdisciplinarno znanstveno područje koje kombinira spoznaje fizike plazme s biomedicinskim i kliničkim znanostima. Hladna atmosferska plazma emitira elektromagnetno zračenje te se sastoji od mnoštva nabijenih i nenabijenih čestica, među kojima su najznačajnije reaktivne kisikove i dušikove vrste. Smatra se da su upravo reaktivne kisikove vrste najvažnije za biološke učinke plazme kao što su inaktivacija mikroorganizama i biofilmova. U dermatologiji se pokazalo da hladna atmosferska plazma pozitivno utječe na zacjeljivanje kroničnih rana. Prvi instrumenti za primjenu hladne plazme na ljudima već su i komercijalno dostupni. Primjena hladne plazme ima velik potencijal za primjenu u onkologiji, ali i u stomatologiji. Mnogobrojne studije dale su vrlo obećavajuće rezultate za primjenu hladne plazme u medicini, no treba imati na umu da mehanizmi međudjelovanja plazme s biološkim tkivom još uvijek nisu u potpunosti razjašnjeni, da nema dogovorom prihvaćene definicije doze koju plazma predaje materiji, da još uvijek nema standardiziranih instrumenata za generiranje i karakterizaciju plazme te da za pravu procjenu potencijala primjene atmosferske plazme u medicini i stomatologiji nedostaje više detaljnih in vivo studija.Ključne riječi: dermatologija; onkologija; plazma; stomatologija Abstract. Physical plasma is an ionized, quasi-neutral gas. It is often said to be the fourth state of matter. For a long time, plasma was used in medicine exclusively because of its thermal properties for sterilization purposes of surgical equipment and medical supplies, and also to cut and cauterize tissue. The possibility to generate cold plasma in atmospheric conditions marked the beginning of a completely new era in the application of plasma in biomedicine. Plasma medicine is a new interdisciplinary field of science that combines the knowledge of plasma physics to biomedical and clinical sciences. Cold atmospheric plasma emits electromagnetic radiation and it consists out of charged and uncharged particles, among those reactive oxygen and nitrogen species are the most important ones. It is considered that reactive oxygen species cause the most important biological plasma effects, such as inactivation of microorganisms and biofilms. It has been shown in dermatology that cold atmospheric plasma has a healing effect on chronic wounds. First instruments for the application of cold plasma in humans are already commercially available. Cold plasma has a great potential for application in oncology and in dentistry. Numerous studies have yielded very promising results for the application of cold plasma in medicine, but it should ...

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Plasma in cancer treatment

Cited by 282 publications

References 42 publications

Electric field and temperature in a target induced by a plasma jet imaged using Mueller polarimetry

Electric field and temperature in a target induced by a plasma jet imaged using Mueller polarimetry

Plasma-induced selectivity in bone cancer cells death

Plasma applications in medicine and dentistry

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