Plasma interleukin-6 in remitted early bipolar I disorder and subjects at high-risk for bipolar disorder

Sanjay, Tarasingh N; Shivakumar, Venkataram; Subbanna, Manjula; Biradar, Shweta U.; Muralidharan, Kesavan; Venkatasubramanian, Ganesan

doi:10.1016/j.ajp.2017.03.014

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…Ultimately, 53 studies were eligible for the systematic review. Four of these did not provide data suitable for the analyses, (Boufidou et al, 2004;Karabulut et al, 2019;Kauer-Sant'Anna et al, 2008;Sanjay et al, 2017); 49 were included in the meta-analysis. (Aas et al, 2017;Bai et al, 2015;Barbosa et al, 2017Barbosa et al, , 2013Barbosa et al, , 2012bBarbosa et al, , 2012aBarbosa et al, , 2011Brietzke et al, 2009;Chakrabarty et al, 2019;Chang et al, 2017;Civil Arslan et al, n.d.;Cunha et al, 2008;da Silva et al, 2017;De Berardis et al, 2008;Dickerson et al, 2007;Doganavsargil-Baysal et al, 2013;Glaus et al, 2018;Guloksuz et al, 2010;Hope et al, 2015Hope et al, , 2011Hope et al, , 2009Hornig et al, 1998;Huang and Lin, 2007;Hung et al, 2007;Jacoby et al, 2016;Kapczinski et al, 2011;Kim et al, 2007;King et al, 2019;Koga et al, 2019;Lesh et al, 2018;Mao et al, 2018;Mizuno et al, 2016;Mondin et al, 2016;Mora et al, 2019;Ortiz-Domínguez et al, 2007;Pantović-Stefanović et al, 2018;…”

Section: Study Selectionmentioning

confidence: 99%

Peripheral levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and interleukin-1β across the mood spectrum in bipolar disorder: A meta-analysis of mean differences and variability

Solmi

Sharma

Osimo

et al. 2021

Brain, Behavior, and Immunity

116

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Section: Study Selectionmentioning

confidence: 99%

Peripheral levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and interleukin-1β across the mood spectrum in bipolar disorder: A meta-analysis of mean differences and variability

Solmi

Sharma

Osimo

et al. 2021

Brain, Behavior, and Immunity

116

View full text Add to dashboard Cite

“…In the early stage of illness development, HR offspring with BDNF VAL/VAL genotype had higher mRNA expression levels than HR offspring who were MET carriers (Duffy et al 2014 ). These data were not replicated in other studies, possibly due to differences in patients ‘clinical disease stages in sample sizes (Nery et al 2016 ; Sanjay et al 2017 ). In addition, body mass index (BMI) may have a moderating effect.…”

Section: Molecular Endophenotypesmentioning

confidence: 75%

Evaluating endophenotypes for bipolar disorder

Guglielmo

Hasler

2021

Int J Bipolar Disord

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Background Phenotypic heterogeneity is a major impediment to the elucidation of the neurobiology and genetics of bipolar disorder. Endophenotype could help in reducing heterogeneity by defining biological traits that are more direct expressions of gene effects. The aim of this review is to examine the recent literature on clinical, epidemiological, neurobiological, and genetic findings and to select and evaluate candidate endophenotypes for bipolar disorder. Evaluating putative endophenotype could be helpful in better understanding the neurobiology of bipolar disorder by improving the definition of bipolar-related phenotypes in genetic studies. In this manner, research on endophenotypes could be useful to improve psychopathological diagnostics in the long-run by dissecting psychiatric macro phenotypes into biologically valid components. Main body The associations among the psychopathological and biological endophenotypes are discussed with respect to specificity, temporal stability, heritability, familiarity, and clinical and biological plausibility. Numerous findings regarding brain function, brain structure, neuropsychology and altered neurochemical pathways in patients with bipolar disorder and their relatives deserve further investigation. Overall, major findings suggest a developmental origin of this disorder as all the candidate endophenotypes that we have been able to select are present both in the early stages of the disorder as well as in subjects at risk. Conclusions Among the stronger candidate endophenotypes, we suggest circadian rhythm instability, dysmodulation of emotion and reward, altered neuroimmune state, attention and executive dysfunctions, anterior cingulate cortex thickness and early white matter abnormalities. In particular, early white matter abnormalities could be the result of a vulnerable brain on which new stressors are added in young adulthood which favours the onset of the disorder. Possible pathways that lead to a vulnerable brain are discussed starting from the data about molecular and imaging endophenotypes of bipolar disorder.

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Relationship of elevated neural cell adhesion molecule 1 with interleukin-10 and disease severity in bipolar disorder

Jesudas

Nandeesha

Menon³

et al. 2020

Asian Journal of Psychiatry

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Plasma interleukin-6 in remitted early bipolar I disorder and subjects at high-risk for bipolar disorder

Cited by 5 publications

References 10 publications

Peripheral levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and interleukin-1β across the mood spectrum in bipolar disorder: A meta-analysis of mean differences and variability

Peripheral levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and interleukin-1β across the mood spectrum in bipolar disorder: A meta-analysis of mean differences and variability

Evaluating endophenotypes for bipolar disorder

Relationship of elevated neural cell adhesion molecule 1 with interleukin-10 and disease severity in bipolar disorder

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