Plasma Kinetics and Urine Profile of Ethyl Glucosides after Oral Administration in the Rat

Mishima, Tomoyuki; Harino, Shinpei; Sugita, Jun; Nakahara, Michio; Suzuki, Tohru; Hayakawa, T.

doi:10.1271/bbb.70485

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…One compound was identified as 2-hydroxy-3-methylbutyric acid; the other remains unknown but is likely a combination of isomers of ethyl glucoside. Of note, ethyl-α-D-glucoside is a known constituent of some alcoholic beverages [38]. Both compounds could discriminate high alcohol consumers from low consumers in EPIC and ATBC despite marked differences in the study designs.…”

Section: Discussionmentioning

confidence: 99%

“…Residuals of f 2 =10 features were statistically significantly correlated with residuals of alcohol intake (Table 2). The first two features corresponded to a compound that could not be unequivocally identified, but had an identical mass, isotope pattern, ion formation (mostly [M+Na] + and [M+HCOOH-H] -) and retention time to ethyl glucoside (HMDB0029968) [38]. However, chromatograms (Supplementary Methods) indicated a lack of specificity, and although fragmentation of the [M+Na] + ion could not be induced, our results suggest the unknown is a combination of ethyl-α-D-glucoside, ethyl-β-D-glucoside, and an additional structural isomer.…”

Section: Biomarker Discovery Analysismentioning

confidence: 99%

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Novel Biomarkers of Habitual Alcohol Intake and Associations With Risk of Pancreatic and Liver Cancers and Liver Disease Mortality

Loftfield

Stępień

Viallon

et al. 2021

JNCI: Journal of the National Cancer Institute

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Background Alcohol is an established risk factor for several cancers, but modest alcohol-cancer associations may be missed due to measurement error in self-reported assessments. Biomarkers of habitual alcohol intake may provide novel insight into the relationship between alcohol and cancer risk. Methods Untargeted metabolomics was used to identify metabolites correlated with self-reported habitual alcohol intake in a discovery dataset from the European Prospective Investigation into Cancer and Nutrition (EPIC; n = 454). Statistically significant correlations were tested in independent datasets of controls from case-control studies nested within EPIC (n = 280) and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC; n = 438) study. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations of alcohol-associated metabolites and self-reported alcohol intake with risk of pancreatic cancer, hepatocellular carcinoma (HCC), liver cancer, and liver disease mortality in the contributing studies. Results Two metabolites displayed a dose-response association with self-reported alcohol intake 2-hydroxy-3-methylbutyric acid and an unidentified compound. A 1-SD (log2) increase in levels of 2-hydroxy-3-methylbutyric acid was associated with risk of HCC (OR = 2.54; 95% CI = 1.51-4.27) and pancreatic cancer (OR = 1.43; 95% CI = 1.03-1.99) in EPIC and liver cancer (OR = 2.00; 95% CI = 1.44-2.77) and liver disease mortality (OR = 2.16; 95% CI = 1.63-2.86) in ATBC. Conversely, a 1-SD (log2) increase in questionnaire-derived alcohol intake was not associated with HCC or pancreatic cancer in EPIC or liver cancer in ATBC but was associated with liver disease mortality (OR = 2.19; 95% CI = 1.60-2.98) in ATBC. Conclusions 2-Hydroxy-3-methylbutyric acid is a candidate biomarker of habitual alcohol intake that may advance the study of alcohol and cancer risk in population-based studies.

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Section: Discussionmentioning

confidence: 99%

Section: Biomarker Discovery Analysismentioning

confidence: 99%