Plasma L-Arginine and Metabolites of Nitric Oxide Synthase in Patients With Left-To-Right Shunt After Intracardiac Repair

Gorenflo, Matthias; Ullmann, Michael V.; Eitel, Katharina; Groß, Jasmin; Fiehn, W.; Hagl, S.; Dreyhaupt, Jens

doi:10.1016/s0012-3692(15)34465-2

Cited by 5 publications

(8 citation statements)

References 11 publications

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“…A human study also showed decreased plasma levels of L-arginine after CPB [17]. Given the role of L-arginine as a NO precursor, providing L-arginine might theoretically increase the production of NO and improved pulmonary vessel relaxation ability.…”

Section: Discussionmentioning

confidence: 97%

Pulmonary Perfusion With L-Arginine Ameliorates Post-Cardiopulmonary Bypass Lung Injury in a Rabbit Model

Chao

Wu²,

Yang

et al. 2011

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 97%

Pulmonary Perfusion With L-Arginine Ameliorates Post-Cardiopulmonary Bypass Lung Injury in a Rabbit Model

Chao

Wu²,

Yang

et al. 2011

Journal of Surgical Research

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“…Whilst most children with PAH will not be treated with anticoagulation, it is recommended that those at high risk of thromboembolism (such as patients with IPAH and reduced cardiac output, indwelling venoatrial shunt or severe polycythemia), should be prescribed warfarin. 127…”

Section: Anticoagulationmentioning

confidence: 99%

Treatment of pediatric pulmonary hypertension

Hawkins

Tulloh²

2009

VHRM

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Pulmonary hypertension was once thought to be a rare condition and only managed in specialized centers. Now however, with the advent of echocardiography, it is found in many clinical scenarios, in the neonate with chronic lung disease, in the acute setting in the intensive care unit, in connective tissue disease and in cardiology pre-and postoperatively. We have a better understanding of the pathological process and have a range of medication which is starting to be able to palliate this previously fatal condition. This review describes the areas that are known in this condition and those that are less familiar. The basic physiology behind pulmonary hypertension and pulmonary vascular disease is explained. The histopathologic process and the various diagnostic tools are described and are followed by the current and future therapy at our disposal.

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“…Nineteen domestic farm piglets (German Landrace) 4 weeks of age and with a body weight of 12 kg [10][11][12][13][14][15][16] [median (range)] were used. The piglets were intubated and ventilated with a respirator (Servo Ventilator 900C, SiemensElema, Umea, Sweden) using tidal volumes of 10 to 15 ml/kg and a respiratory rate of 12 to 15 breaths per minute.…”

Section: Surgical Proceduresmentioning

confidence: 99%

“…Plasma cGMP was measured by radioimmunoassay using a kit from Immunotech SA (Marseille, France) as previously described [15]. Plasma ET-1 was determined by radioimmunoassay using a kit purchased from GE Health Sciences (Freiburg, Germany).…”

Section: Real-time Rt-pcrmentioning

confidence: 99%

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Pulmonary vascular changes in piglets with increased pulmonary blood flow and pressure

et al. 2007

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In this model of pulmonary vascular disease, high pulmonary blood flow was created by an anastomosis between the left subclavian artery and the main pulmonary artery [Blalock-Taussig (BT) shunt] in 4-week-old piglets (n = 6). Additional ligation of the left pulmonary artery (LPA) was used to increase pulmonary artery pressure (n = 6). Seven piglets were sham-operated. After 3 months, mean pulmonary artery pressure was higher in animals with BT shunt and LPA ligation (22 +/- 5; mean+/-SD) compared to sham-operated animals (15 +/- 2). In addition, thickening of the medial coat (20.1 +/- 2.8% versus 13.6 +/- 3.1% wall thickness) and increased immunostaining for vascular endothelial growth factor A (VEGF-A) were observed. Relative gene expression for endothelin-converting enzyme-1 (ECE-1) mRNA was 1.8 times higher, and VEGF-A mRNA was 2.5 times higher in pigs with BT shunt and LPA ligation compared with sham-operated animals. VEGF receptor-1 and VEGF receptor-2 mRNA was lower in shunted animals and in animals with additional ligation of LPA. Upregulation of ECE-1 and VEGF-A, as well as changes in VEGFR expression in the pulmonary hypertensive lung, may contribute to pulmonary vascular changes.

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Plasma L-Arginine and Metabolites of Nitric Oxide Synthase in Patients With Left-To-Right Shunt After Intracardiac Repair

Cited by 5 publications

References 11 publications

Pulmonary Perfusion With L-Arginine Ameliorates Post-Cardiopulmonary Bypass Lung Injury in a Rabbit Model

Pulmonary Perfusion With L-Arginine Ameliorates Post-Cardiopulmonary Bypass Lung Injury in a Rabbit Model

Treatment of pediatric pulmonary hypertension

Pulmonary vascular changes in piglets with increased pulmonary blood flow and pressure

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