Plasma lactate as prognostic marker of septic shock with acute respiratory distress syndrome

Nanda, Saurav Narayan; Suresh, D R

doi:10.1007/s12291-009-0078-y

Cited by 6 publications

(8 citation statements)

References 13 publications

(7 reference statements)

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“…A significant decrease in PaCO 2 values was observed in all of the nebuliser treatment groups with the highest decreases in PaCO 2 obtained in Group 2 and Group 5 at the end of the treatment (Table 2). Blood PaCO 2 and lactate concentrations were suggested to be useful metabolic markers for the determination of tissue hypoxia in infants (Nanda and Suresh 2009;Boode 2010). It has been reported that blood lactate concentrations of between 2 and 4 mmol/l should be interpreted with caution, whereas values above 4 mmol/l are indicative of a clinically important disruption of oxygen transport and cellular metabolism; plasma lactate concentrations above 4 mmol/l in cattle with pneumonia indicate that death will occur within 24 h Radostits 2000).…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of combinations of nebulised fluticasone, salbutamol and furosemide on lung function in premature calves with respiratory distress syndrome

Yıldız¹,

Ok²

2017

Vet. Med.

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Surfactant deficiency, poor development of the lung structure and fibrosis as a result of inflammation are thought to play an important role in the development of respiratory distress syndrome in premature calves. Nebulised steroid (fluticasone), bronchodilator (salbutamol) and diuretics (furosemide) can be used in combination alongside standard treatment procedures for premature calves, and might improve viability as observed in infants, foals and horses with pulmonary disorders. Twenty-five premature calves with respiratory distress syndrome were used in this study. Oxygen and supportive treatment were administered to all groups. The first group was used as a control group (Group 1). The nebulised drug combinations were as follows: Group 2: fluticasone + salbutamol, Group 3: salbutamol + furosemide, Group 4: fluticasone + furosemide and Group 5: fluticasone + salbutamol + furosemide. During the 72-h time period of the study, fluticasone (15 µg/kg/12 h), salbutamol (0.025 mg/kg/6 h) and furosemide (1 mg/kg/12h) were applied for 5 min. Arterial blood samples were collected from the auricular artery at 0 h and at 1, 24, 48 and 72 h for blood gas analysis. Significant (P < 0.05) increases in arterial partial oxygen, oxygen saturation and peripheral oxygen saturation and decreases in arterial partial carbon dioxide, lactate and respiration rate were observed in all the nebulised treatment groups, while a statistical difference was observed only for arterial partial carbon dioxide in control group. When comparing the treated groups with the control, it may be concluded that nebulised drugs are highly effective in the therapy of premature calves with respiratory distress syndrome, while the different nebulised groups exhibited similar efficacies.

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Section: Discussionmentioning

confidence: 99%

Clinical efficacy of combinations of nebulised fluticasone, salbutamol and furosemide on lung function in premature calves with respiratory distress syndrome

Yıldız¹,

Ok²

2017

Vet. Med.

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“…Plasma lactate and pCO 2 concentrations may be useful metabolic markers for determination of tissue hypoxia. These markers are associated with increased mortality in preterm newborns with RDS (Yoxall and Weindling 1996, Nanda and Suresh 2009, Boode 2010). It could be said that the cut‐off values of venous lactate and pCO 2 levels at admission may be crucial as mortality indicator for prognosis in premature calves with RDS.…”

Section: Discussionmentioning

confidence: 99%

Venous lactate, pH and partial pressure of carbon dioxide levels as prognostic indicators in 110 premature calves with respiratory distress syndrome

et al. 2017

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Hyperlactatemia, hypercapnia, low pH and low oxygen saturation (SatO) are commonly observed in premature calves. These clinical indicators are associated with increased mortality in preterm human newborns with respiratory distress syndrome (RDS). The aim of this study was to investigate the prognostic importance of venous pH, partial pressure of carbon dioxide (pCO) and lactate level and which parameters are related with mortality in premature calves with RDS. All premature calves (52 male/58 female) were admitted to clinic within 12-24 hours after birth and blood samples were also taken into heparinised plastic syringes from the jugular vein within 30 minutes following admission. Diagnosis of RDS was made by both clinical signs and blood gas results. For the evaluation of independent samples, t test was used to compare the venous blood gas indicators of surviving and non-surviving premature calves. Receiver operating characteristics curves were used to determine a cut-off value in terms of lactate and pCO measurements among non-surviving and surviving calves. Venous pH, pCO, SatO, base deficit, bicarbonate (HCO) and lactate levels showed a significant variance between surviving and non-surviving calves. Mean venous pH, pCO, SatO, lactate levels in non-surviving premature calves was 7.05, 78.9 mm Hg, 16.1 per cent and 9.50 mmol/l, respectively. Mean pH, pCO, SatO and lactate levels in surviving premature calves were 7.29, 56.3 mm Hg, 25.5 per cent and 5.1 mmol/l, respectively. The cut-off values for lactate and pCO were 7.5 mmol/l and 63.5 mm Hg, respectively. In conclusion, the results of the study show that venous blood lactate and pCO have prognostic importance in premature calves with RDS.

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“…The serum lactate is a well-validated marker of hypoperfusion, resuscitation, and mortality. [ 5 6 7 8 9 10 11 12 13 14 15 16 ] BD has also been utilized as a prognostic marker in various studies. [ 17 18 19 20 21 ] Recently, poor preoperative oxygenation has been found to be one of the significant factors to affect mortality in TOF patients.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated blood lactate level associated with metabolic acidosis is common among critically ill patients with systemic hypoperfusion and tissue hypoxia. [ 1 2 ] Several studies have suggested that blood lactate concentration has prognostic value in patients with trauma,[ 5 6 7 8 9 10 ] septic shock,[ 11 12 ] acute respiratory distress syndrome,[ 13 ] and cardiac surgeries. [ 14 15 16 ]…”

Section: Discussionmentioning

confidence: 99%

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Basic arterial blood gas biomarkers as a predictor of mortality in tetralogy of Fallot patients

et al. 2017

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Background:Serum lactate and base deficit have been shown to be a predictor of morbidity and mortality in critically ill patients. Poor preoperative oxygenation appears to be one of the significant factors that affects early mortality in tetralogy of Fallot (TOF). There is little published literature evaluating the utility of serum lactate, base excess (BE), and oxygen partial pressure (PO2) as simple, widely available, prognostic markers in patients undergoing surgical repair of TOF.Materials and Methods:This prospective, observational study was conducted in 150 TOF patients, undergoing elective intracardiac repair. PO2, BE, and lactate levels at three different time intervals were recorded. Arterial blood samples were collected after induction (T1), after cardiopulmonary bypass (T2), and 48 h (T3) after surgery in the Intensive Care Unit (ICU). To observe the changes in PO2, BE, and lactate levels over a period of time, repeated measures analysis was performed with Bonferroni method. The receiver operating characteristics (ROC) analysis was used to find area under curve (AUC) and cutoff values of various biomarkers for predicting mortality in ICU.Results:The patients who could not survive showed significant elevated lactate levels at baseline (T1) and postoperatively (T2) as compared to patients who survived after surgery (P < 0.001). However, in nonsurvivors, the BE value decreased significantly in the postoperative period in comparison to survivors (−2.8 ± 4.27 vs. 5.04 ± 2.06) (P < 0.001). In nonsurvivors, there was a significant fall of PO2 to a mean value of 59.86 ± 15.09 in ICU (T3), whereas those who survived had a PO2 of 125.86 ± 95.09 (P < 0.001). The ROC curve analysis showed that lactate levels (T3) have highest mortality predictive value (AUC: 96.9%) as compared to BE (AUC: 94.5%) and PO2 (AUC: 81.1%).Conclusion:Serum lactate and BE may be used as prognostic markers to predict mortality in patients undergoing TOF repair. The routine analysis of these simple, fast, widely available, and cost-effective biomarkers should be encouraged to predict prognosis of TOF patients.

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Plasma lactate as prognostic marker of septic shock with acute respiratory distress syndrome

Abstract: ABSTRACT

Cited by 6 publications

References 13 publications

Clinical efficacy of combinations of nebulised fluticasone, salbutamol and furosemide on lung function in premature calves with respiratory distress syndrome

Clinical efficacy of combinations of nebulised fluticasone, salbutamol and furosemide on lung function in premature calves with respiratory distress syndrome

Venous lactate, pH and partial pressure of carbon dioxide levels as prognostic indicators in 110 premature calves with respiratory distress syndrome

Basic arterial blood gas biomarkers as a predictor of mortality in tetralogy of Fallot patients

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