Plasma leptin and colorectal cancer risk: A prospective study in Northern Sweden

Stattin, Pär; Palmqvist, Richard; Söderberg, Stefan; Biessy, Carine; Ardnor, B.; Hallmans, Göran; Kaaks, Rudolf; Olsson, Tommy

doi:10.3892/or.10.6.2015

Cited by 129 publications

(131 citation statements)

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“…Several reports have described the mitogenic effects of leptin on gastric (10), breast (11), ovarian (12), prostate (13) and endometrial cancer cells (14). Two studies demonstrated that increased leptin levels are associated with greater risk of CRC development, particularly in males (15,16). Furthermore, in colon epithelial cells, leptin was found to induce chemokine production associated with macrophage activation similar to that observed in an adenomatous polyposis coli genotype (17,18).…”

Section: Introductionmentioning

confidence: 89%

Leptin-induced adhesion and invasion in colorectal cancer cell lines

et al. 2014

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Abstract. Leptin, which is encoded by the obese gene, is a multifunctional neuroendocrine peptide that regulates appetite, bone formation, reproductive function and angiogenesis. The aims of the present study were to investigate the expression of leptin in 80 patients with colorectal cancer (CRC) and to determine the effects of leptin on the malignant properties of CRC cells. We evaluated the expression of leptin in tissues of 80 patients with CRC. Suspension cultures were used to isolate CRC stem cells following pretreatment with leptin. We analyzed the effects of leptin on the adhesion and invasive capacities of CRC cell lines. The effects of leptin on JAK and ERK activation were examined using western blotting. Leptin expression was associated with CRC progression and increased the number and size of spheroid formation by CRC cell lines. Leptin enhanced cell invasion and adhesion and activated JAK and ERK signaling in the CRC cell lines. The present study demonstrated that leptin influences the growth and survival of CRC stem cells and regulates adhesion and invasion of colorectal carcinoma through activation of the JAK and ERK signaling pathways.

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Section: Introductionmentioning

confidence: 89%

Leptin-induced adhesion and invasion in colorectal cancer cell lines

et al. 2014

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“…42 It has been recently theorized that estrogen levels may modify the effect of insulin-related mechanisms on colon cancer risk. Hormone replacement therapy in observational studies has been inversely associated with the risk of colorectal cancers.…”

Section: Discussionmentioning

confidence: 99%

BMI and waist circumference as predictors of lifetime colon cancer risk in Framingham Study adults

et al. 2004

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BACKGROUND: It is unclear whether the increased risk of colon cancer associated with obesity differs for men and women, by distribution of body fat, or by location of the tumor. The primary goal of this study was to address these questions. METHODS: Eligible subjects from the Framingham Study cohort were classified according to body mass index (BMI) and waist size during two age periods: 30-54 y (n ¼ 3764) and 55-79 y (n ¼ 3802). All eligible men and women were cancer-free at baseline and had complete information on the following potential confounders: age, sex, education, height, activity, smoking, and alcohol. There were 157 incident lifetime cases of colon cancer among those followed beginning at 30-54 y of age and 149 lifetime cases among those whose follow up began at 55-79 y. Subjects were stratified further by gender, activity, and tumor location. The Cox Proportional Hazards Models were used to adjust for possible confounding by the above-described factors. RESULTS: A BMI Z30 led to a 50% increased risk (95% CI: 0.92-2.5) of colon cancer among middle-aged (30-54 y) and a 2.4-fold increased risk (95% CI: 1.5-3.9) among older (55-79 y) adults. The BMI effect was stronger for men than for women and for cases occurring in the proximal colon. These adverse effects generally diminished when waist was added to the multivariable models. A larger waist size (Z99.1 cm (39 in) and 101.6 cm (40 in) for women and men, respectively) was associated with a twofold increased risk of colon cancer; this risk increased linearly with increasing waist size and was evident for both proximal and distal colon cancer. There was no attenuation of these effects when BMI was added to the multivariable models. A larger waist had a particularly adverse effect among sedentary subjects (relative risk (RR) ¼ 4.4 for middle-aged adults; RR ¼ 3.0 for older adults). CONCLUSION: These findings suggest that waist circumference is a stronger predictor of colon cancer risk than is BMI, and that central obesity is responsible for an increased risk of cancer of both the proximal and distal colon.

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“…For instance, Stattin et al (2003b) observed that elevated levels of circulating leptin were associated with about a twofold increase in risk of colorectal cancer in men, but not in women. On the other hand, Tessitore et al (2000) found no difference between serum leptin levels in cancer patients and controls.…”

Section: Colorectal Cancermentioning

confidence: 99%

Leptin and cancer

Garofalo

Surmacz

2005

Journal Cellular Physiology

556

497

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The prevalence of obesity has markedly increased over the past two decades, especially in the industrialized countries. While the impact of excess body weight on the development of cardiac disease and diabetes has been well documented, the link between obesity and carcinogenesis is just being recognized. This review will focus on the link between leptin, a cytokine that is elevated in obese individuals, and cancer development. First, we briefly discuss the biological functions of leptin and its signaling pathways. Then, we summarize the effects of leptin on different cancer types in experimental cellular and animal models. Next, we analyze epidemiological data on the relationship between obesity and the presence of cancer or cancer risk in patients. Finally, leptin as a target for cancer treatment and prevention will be discussed.

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Plasma leptin and colorectal cancer risk: A prospective study in Northern Sweden

Cited by 129 publications

References 0 publications

Leptin-induced adhesion and invasion in colorectal cancer cell lines

Leptin-induced adhesion and invasion in colorectal cancer cell lines

BMI and waist circumference as predictors of lifetime colon cancer risk in Framingham Study adults

Leptin and cancer

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