1997
DOI: 10.1042/cs0930113
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Plasma Leptin, Energy Intake and Hunger following Total Hip Replacement Surgery

Abstract: 1. This study aimed to investigate the possible role of leptin in post-traumatic anorexia by making pre- and post-operative (0-8 days) measurements of circulating leptin concentrations in six patients undergoing elective total hip replacement for osteoarthritis. 2. Mean daily hunger rating (four categories) and food intake (assessed by food record charts) were measured pre-operatively, as well as post-operatively for the first 5 days (days 0-5). Leptin concentrations, circulating metabolites [glucose, non-este… Show more

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Cited by 48 publications
(15 citation statements)
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“…Long-term leptin treatment, however, causes moderate weight reduction. Short-term changes in leptin serum concentrations may modulate appetite and energy expenditure in humans during fasting and after major surgery (12). Leptin is known to play an important role in the regulation of weight gain in early infancy and shows a relationship between its concentration and fetal growth (13±15).…”
Section: Introductionmentioning
confidence: 99%
“…Long-term leptin treatment, however, causes moderate weight reduction. Short-term changes in leptin serum concentrations may modulate appetite and energy expenditure in humans during fasting and after major surgery (12). Leptin is known to play an important role in the regulation of weight gain in early infancy and shows a relationship between its concentration and fetal growth (13±15).…”
Section: Introductionmentioning
confidence: 99%
“…Human PBMCs and murine splenocytes show marked cellular clumping when incubated with leptin (7), and leptin increases Th1 (IFN-␥ and IL-2) and suppresses Th2 (IL-4) cytokine production from activated human lymphocytes (5). Circulating concentrations of TNF-␣ and IL-6 strongly correlate with leptin levels in humans (8), and leptin levels rise after surgical stress (9). Leptin receptors are expressed on human umbilical cord leukocytes (10), and leptin activates umbilical cord monocytes, polymorphonuclear cells, and lymphocytes (11).…”
mentioning
confidence: 99%
“…Studies of critically-ill patients with sepsis demonstrated modest increases in circulating leptin concentration, and suggested that this response had positive prognostic implications (Bornstein et al 1998a). Although elective surgery in man did lead to an increase in circulating leptin concentrations (Stratton et al 1997), the increase was, however, trivial and short-lived. We were unable to demonstrate increased serum leptin concentrations in critically-ill insulin-resistant patients with abdominal sepsis, and leptin concentrations failed to correlate with insulin resistance or hypermetabolism in these patients .…”
Section: Mechanisms Of Insulin Resistance In Critical Illnessmentioning
confidence: 99%