Plasma let-7i, miR-16, and miR-221 levels as candidate biomarkers for the assessment of ankylosing spondylitis in Mexican patients naïve to anti-TNF therapy

Reyes-Loyola, Paola; Rodríguez-Henríquez, Pedro; Ballinas-Verdugo, Martha A; Amezcua-Castillo, Luis M; Juárez-Vicuña, Yaneli; Jiménez-Rojas, Valentín; Márquez-Velasco, Ricardo; Sánchez‐Muñoz, Fausto; Amezcua-Guerra, Luis M.

doi:10.1007/s10067-019-04509-1

Cited by 11 publications

(6 citation statements)

References 14 publications

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“…MiR-30a was downregulated in serum/plasma of radiographic axial spondyloarthritis patients compared to healthy individuals [ 98 ]. In turn, let-7i was upregulated in T cells [ 99 ] and plasma [ 100 ] of AS patients compared to controls. In our analysis, both miR-30a-5p and let-7i-5p levels were higher in AS patient EVs after therapy compared to that before treatment and RA cases, respectively.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Extracellular Vesicle MicroRNA Expression Repertoire in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis Treated with TNF Inhibitors

et al. 2021

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Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) belong to the most common inflammatory rheumatic diseases. MicroRNAs (miRNAs) are small 18–22 RNA molecules that function as posttranscriptional regulators. They are abundantly present within extracellular vesicles (EVs), small intercellular communication vesicles that can be found in bodily fluids and that have key functions in pathological and physiological pathways. Recently, EVs have gained much interest because of their diagnostic and therapeutic potential. Using NanoString profiling technology, the miRNA repertoire of serum EVs was determined and compared in RA and AS patients before and after anti-TNF therapy to assess its potential use as a diagnostic and prognostic biomarker. Furthermore, possible functional effects of those miRNAs that were characterized by the most significant expression changes were evaluated using in silico prediction algorithms. The analysis revealed a unique profile of differentially expressed miRNAs in RA and AS patient serum EVs. We identified 12 miRNAs whose expression profiles enabled differentiation between RA and AS patients before induction of anti-TNF treatment, as well as 4 and 14 miRNAs whose repertoires were significantly changed during the treatment in RA and AS patients, respectively. In conclusion, our findings suggest that extracellular vesicle miRNAs could be used as potential biomarkers associated with RA and AS response to biological treatment.

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Section: Discussionmentioning

confidence: 99%

Exploring the Extracellular Vesicle MicroRNA Expression Repertoire in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis Treated with TNF Inhibitors

et al. 2021

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“…Accordingly, these six plasma miR signature can become gorgeous non-invasive biomarkers for AS diagnosis. Recently, Reyes-Loyola et al (2019) assessed plasma levels of ncRNAs in Mexican AS patients. They found plasma lnc let-7 was higher in patients and might serve as a diagnostic biomarker in Mexican AS patients.…”

Section: Aberrant Epigenetic Regulation In Asmentioning

confidence: 99%

The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis

Liao

Tsai

Lai

et al. 2022

Front. Cell Dev. Biol.

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Ankylosing spondylitis (AS) or radiographic axial spondyloarthritis is a chronic immune-mediated rheumatic disorder characterized by the inflammation in the axial skeleton, peripheral joints, and soft tissues (enthesis, fascia, and ligament). In addition, the extra-skeletal complications including anterior uveitis, interstitial lung diseases and aortitis are found. The pathogenesis of AS implicates an intricate interaction among HLA (HLA-B27) and non-HLA loci [endoplasmic reticulum aminopeptidase 1 (ERAP1), and interleukin-23 receptor (IL23R), gut dysbiosis, immune plasticity, and numerous environmental factors (infections, heavy metals, stress, cigarette smoking, etc.) The latter multiple non-genetic factors may exert a powerful stress on epigenetic regulations. These epigenetic regulations of gene expression contain DNA methylation/demethylation, histone modifications and aberrant non-coding RNAs (ncRNAs) expression, leading to inflammation and immune dysfunctions. In the present review, we shall discuss these contributory factors that are involved in AS pathogenesis, especially the aberrant ncRNA expression and its effects on the proinflammatory cytokine productions (TNF-α, IL-17 and IL-23), T cell skewing to Th1/Th17, and osteoclastogenic/osteogenic differentiation. Finally, some potential investigatory approaches are raised for solving the puzzles in AS pathogenesis.

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“…Recently, Reyes-Loyola and colleagues assessed the mRNA levels of let-7i, miR-16 and miR-221 in AS patients’ plasma from a Mexican cohort of 15 patients, naïve to TNF-α treatment and 13 controls [ 48 ]. The authors also measured the serum levels of CRP, MMP1 and MMP9 correlating the results obtained.…”

Section: Mirna Regulation In Asmentioning

confidence: 99%

MicroRNAs in ankylosing spondylitis: Function, potential and challenges

Motta

Carena

Selmi

et al. 2020

Journal of Translational Autoimmunity

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Epigenetic mechanisms such as DNA methylation, histone modifications and non-coding RNA, are considered the essential connection between a disorder’s onset and the environment, on a permissive genetic background. Among autoimmune and inflammatory-mediated disorders, Ankylosing Spondylitis (AS), a chronic arthritis of the spine, is a very good example for the weight of epigenetics’ contribution. MicroRNAs (miRNAs) are single-stranded nucleotides which regulate gene expression and are involved in pathological and physiological processes. In this manuscript we provide a clarification on the role of microRNAs in AS, with a focus on the mechanisms of pathogenesis. In specific, we have examined the contribution of miRNAs in the processes of inflammation, new bone formation and T-cell function, and the pathways (i.e. Wnt, BMP, TGFβ signalling etc.) they regulate. The utility of miRNAs in better understanding AS pathogenesis is undisputed and their utility as therapeutic opportunity is strongly increasing.

show abstract

Plasma let-7i, miR-16, and miR-221 levels as candidate biomarkers for the assessment of ankylosing spondylitis in Mexican patients naïve to anti-TNF therapy

Cited by 11 publications

References 14 publications

Exploring the Extracellular Vesicle MicroRNA Expression Repertoire in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis Treated with TNF Inhibitors

Exploring the Extracellular Vesicle MicroRNA Expression Repertoire in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis Treated with TNF Inhibitors

The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis

MicroRNAs in ankylosing spondylitis: Function, potential and challenges

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