Plasma level of norepinephrine, cyclic AMP and cyclic GMP in essential hypertension.

Ogawa, Kouichi; Matsuno, Tsuguo; Tsuchiya, Seiya; Ban, Masaaki; Minaguchi, Kazue

doi:10.1253/jcj.45.654

Cited by 12 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of recent extensive literature reviews, as well as several large-scale comparative studies of patients with essential hypertension and of normotensive control subjects, have suggested that a subgroup of hypertensives have elevated resting, supine, venous plasma norepinephrine (NE)' levels, consistent with augmented sympathetic nervous system activity in some patients with essential hypertension (1)(2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Plasma l-[3H]norepinephrine, d-[14C]norepinephrine, and d,l-[3H]isoproterenol kinetics in essential hypertension.

Goldstein¹,

Horwitz²,

Keiser³

et al. 1983

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T We infused tracer-labeled 1-[3H]-norepinephrine, d-['4C]norepinephrine, and d,l-[3H]isoproterenol simultaneously into patients with essential hypertension and into normotensive control subjects, in order to determine whether abnormalities in the disappearance kinetics of these substances characterized the hypertensive patients. The mean preinfusion venous plasma norepinephrine concentration was somewhat higher in the hypertensive group (260 vs. 194 pg/ml, P = 0.06), but the groups did not differ in the disappearance kinetics of 1-or d-norepinephrine or of isoproterenol. Preinfusion plasma norepinephrine was significantly positively correlated with calculated spillover rates in both the hypertensive and normotensive groups, but not with norepinephrine clearances. The dli ratio in plasma norepinephrine was the same as in the infusate during and after the infusion, even after pretreatment with the neuronal norepinephrine uptake blocker, desipramine. Because isoproterenol is not taken up by nerve endings, the ratio of [3H]isoproterenol to l-[3H]norepinephrine increased after the infusion ended. This increase was almost completely abolished by pretreatment with desipramine. These results indicate that (a) increased plasma norepinephrine levels seen in some patients with essential hypertension result from increased sympathetic neural activity and not from decreased clearance of norepinephrine, (b) changes in the isoproterenol/norepinephrine ratio after simultaneous infusion of both provide an index of neuronal norepinephrine uptake in man, and (c) neuronal norepinephrine uptake is not stereospecific.

show abstract

Section: Introductionmentioning

confidence: 99%

Plasma l-[3H]norepinephrine, d-[14C]norepinephrine, and d,l-[3H]isoproterenol kinetics in essential hypertension.

Goldstein¹,

Horwitz²,

Keiser³

et al. 1983

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…Several endocrine systems other than PTH have an effect on the concentration of cAMP in plasma, including catecholamines, glucagon, vasopressin, adrenocorticotropic hormone (ACTH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH) and gastrin [ 51. Adrenaline stimulates the beta-2-adrenoreceptor and cAMP is formed as a second messenger [ 6 ] , Some studies have reported elevated levels of P-cAMP [7] and U-CAMP [l] in hypertensive patients compared with normotensive controls, whereas others have failed to show any correlation between hypertension and cAMP [8]. The concentration of P-PTH has been found to be elevated in certain groups of hypertensives [ 1, 91 who also had elevated levels of U-CAMP and U-Ca.…”

Section: Introductionmentioning

confidence: 99%

High urinary cAMP in hypertensives despite careful drug treatment—an epidemiological study from the Dalby population

Nilsson

Lindholm

Winther

et al. 1990

Journal of Internal Medicine

View full text Add to dashboard Cite

The correlation between serum calcium (S-Ca), plasma parathyroid hormone (P-PTH) and hypertension was determined in a population-based, cross-sectional study of carefully treated hypertensives (n = 391; diastolic blood pressure 90.2 mmHg; 57 years) compared with normotensive controls (n = 328; diastolic blood pressure 82.1 mmHg; 57 years). Levels of urinary cyclic-adenosinemonophosphate (U-cAMP), but not of plasma cAMP (P-cAMP), were higher (P less than 0.001) in hypertensives than in controls. This was the case regardless of the type of drug treatment and the blood pressure level that was reached. U-cAMP correlated with adrenaline in multivariate analyses. S-Ca levels were higher (P less than 0.001) and S-Mg levels were lower (P less than 0.001) in hypertensives than in controls. This was not explained by thiazide treatment. Thus, despite 'adequate' blood pressure reduction, substantial differences in S-Ca, S-Mg and U-cAMP still exist between hypertensives and normotensive controls.

show abstract

The atrial natriuretic factor: Its physiology and biochemistry

Genest¹,

Cantin²,

Anand‐Srivastava³

et al. 1988

Reviews of Physiology, Biochemistry and Pharmacology, Volume 110

104

View full text Add to dashboard Cite

Plasma level of norepinephrine, cyclic AMP and cyclic GMP in essential hypertension.

Cited by 12 publications

References 10 publications

Plasma l-[3H]norepinephrine, d-[14C]norepinephrine, and d,l-[3H]isoproterenol kinetics in essential hypertension.

Plasma l-[3H]norepinephrine, d-[14C]norepinephrine, and d,l-[3H]isoproterenol kinetics in essential hypertension.

High urinary cAMP in hypertensives despite careful drug treatment—an epidemiological study from the Dalby population

The atrial natriuretic factor: Its physiology and biochemistry

Contact Info

Product

Resources

About