Plasma Levels and Efficacy of Imipramine Treatment for Enuresis

Fritz, Gregory K.; Rockney, Randy; Yeung, Albert

doi:10.1097/00004583-199401000-00009

Cited by 41 publications

(16 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Three of these were level 1b (120,127,128) and six were level 2b (99,109,112,(129)(130)(131). Among these prospective trials, the lowest dosages of imipramine associated with toxicity were 50-200 mg/day, which were associated with agitation, flushes, and insomnia (129).…”

Section: Imipraminementioning

confidence: 99%

Tricyclic antidepressant poisoning: an evidence-based consensus guideline for out-of-hospital management

Woolf

Erdman

Nelson

et al. 2007

Clinical Toxicology

130

View full text Add to dashboard Cite

American Association of Poison Control Centers, Washington, District of Columbia, USAA review of U.S. poison center data for 2004 showed over 12,000 exposures to tricyclic antidepressants (TCAs). A guideline that determines the conditions for emergency department referral and prehospital care could potentially optimize patient outcome, avoid unnecessary emergency department visits, reduce healthcare costs, and reduce life disruption for patients and caregivers. An evidencebased expert consensus process was used to create the guideline. Relevant articles were abstracted by a trained physician researcher. The first draft of the guideline was created by the lead author. The entire panel discussed and refined the guideline before distribution to secondary reviewers for comment. The panel then made changes based on the secondary review comments. The objective of this guideline is to assist poison center personnel in the appropriate prehospital triage and management of patients with suspected ingestions of TCAs by 1) describing the manner in which an ingestion of a TCA might be managed, 2) identifying the key decision elements in managing cases of TCA ingestion, 3) providing clear and practical recommendations that reflect the current state of knowledge, and 4) identifying needs for research. This guideline applies to ingestion of TCAs alone. Co-ingestion of additional substances could require different referral and management recommendations depending on their combined toxicities. This guideline is based on the assessment of current scientific and clinical information. The panel recognizes that specific patient care decisions may be at variance with this guideline and are the prerogative of the patient and the health professionals providing care, considering all the circumstances involved. This guideline does not substitute for clinical judgment. Recommendations are in chronological order of likely clinical use. The grade of recommendation is in parentheses. 1) Patients with suspected self-harm or who are the victims of malicious administration of a TCA should be referred to an emergency department immediately (Grade D). 2) Patients with acute TCA ingestions who are less than 6 years of age and other patients without evidence of self-harm should have further evaluation including standard history taking and determination of the presence of co-ingestants (especially other psychopharmaceutical agents) and underlying exacerbating conditions, such as convulsions or cardiac arrhythmias. Ingestion of a TCA in combination with other drugs might warrant referral to an emergency department. The ingestion of a TCA by a patient with significant underlying cardiovascular or neurological disease should cause referral to an emergency department at a lower dose than for other individuals. Because of the potential severity of TCA poisoning, transportation by EMS, with close monitoring of clinical status and vital signs en route, should be considered (Grade D). 3) Patients who are symptomatic (e.g., weak, drowsy, dizzy, tremulous, pal...

show abstract

Section: Imipraminementioning

confidence: 99%

Tricyclic antidepressant poisoning: an evidence-based consensus guideline for out-of-hospital management

Woolf

Erdman

Nelson

et al. 2007

Clinical Toxicology

130

View full text Add to dashboard Cite

show abstract

“…Recent data suggest that the response to desmopressin might be related to nocturnal ADH secretion; children with the highest or lowest concentrations of ADH responded less well than children with an ‘average’ ADH secretion [16]. The efficacy of tricyclic antidepressants for enuresis has been reported [17] and seems to be dose‐related [18], but its mechanism of action remains unclear [19].…”

Section: Introductionmentioning

confidence: 99%

Decreased nocturnal urinary antidiuretic hormone excretion in enuresis is increased by imipramine

Tomasi

Siracusano

Monni³

et al. 2001

BJU International

View full text Add to dashboard Cite

Objective To assess the role of integrated nocturnal antidiuretic hormone (ADH) secretion in children with enuresis, and possible modi®cations induced by treatment with imipramine. Patients and methods The morning plasma ADH and nocturnal urinary ADH integrated concentrations were measured in 18 consecutive enuretic children (patients) and 21 age-and sex-matched controls admitted for minor treatment. Diurnal and nocturnal urine production, and plasma and urinary osmolality were also determined; lumbosacral radiography and uro¯owmetry were undertaken in the patients.

show abstract

“…Although tricyclics and desmopressin are effective in reducing the number of wet nights while taking the drugs, most children relapse after stopping active treatment [3]. We used a low dose (0.8 mg/kg), but Fritz et al [20] evaluated plasma levels and efficacy of imipramine at four different doses: 1.0 mg/kg, 1.5 mg/kg, 2.0 mg/kg, and 2.5 mg/kg. They found that efficacy was moderately but significantly related to increasing dose.…”

Section: Discussionmentioning

confidence: 99%

Comparison between imipramine and imipramine combined with pseudoephedrine in 5–12-year-old children with uncomplicated enuresis: A double-blind clinical trial

Zadeh

Moslemi

Zadeh

2011

Journal of Pediatric Urology

View full text Add to dashboard Cite

Plasma Levels and Efficacy of Imipramine Treatment for Enuresis

Cited by 41 publications

References 5 publications

Tricyclic antidepressant poisoning: an evidence-based consensus guideline for out-of-hospital management

Tricyclic antidepressant poisoning: an evidence-based consensus guideline for out-of-hospital management

Decreased nocturnal urinary antidiuretic hormone excretion in enuresis is increased by imipramine

Comparison between imipramine and imipramine combined with pseudoephedrine in 5–12-year-old children with uncomplicated enuresis: A double-blind clinical trial

Contact Info

Product

Resources

About