Plasma levels of adiponectin and chemerin are associated with early stage of atherosclerosis in older adults with type 2 diabetes mellitus

Abstract

Objective Adipokines, such as adiponectin and chemerin, regulate fat metabolism and are critical for the development of atherosclerosis. Investigating the correlations of adiponectin and chemerin with atherosclerosis in older adults with type 2 diabetes mellitus (T2DM) will shed light on the search for new markers for early diagnosis of diabetic atherosclerosis. Methods A total of 120 older T2DM patients and nine healthy controls were enrolled in this study. The clinical parameters, such as brachial‐ankle pulse wave velocity (ba‐PWV), adiponectin, and chemerin, were examined and recorded. T2DM subjects were divided into three groups according to ba‐PWV level (high, medium, or low). The data were processed and analyzed by identical methods. Results Significantly higher chemerin and lower adiponectin levels were detected in the plasma of T2DM patients than in healthy controls. The plasma levels of chemerin and adiponectin were negatively correlated in T2DM patients. Moreover, chemerin and adiponectin were significantly correlated with body mass index, ankle‐brachial index, insulin, and ba‐PWV. Multiple linear regression analysis revealed that chemerin and adiponectin were independently affecting ba‐PWV. Conclusion Adiponectin and chemerin are potential markers for diagnosis and monitoring of early stage of atherosclerosis in older adults with T2DM. Further clinical investigations are required to confirm these markers.

Changes in adipokine levels and metabolic profiles following bariatric surgery

“…Similar weight loss has also been described in previous studies [ 23 – 26 ]. We found that the mean levels of triglycerides, glucose and glycated hemoglobin in the patients qualified for surgery were higher than in the control group, that is also in agreement with previous studies [ 27 , 28 ]. We also observed several beneficial tendencies in blood markers following a 12-month follow-up period like decrease of glucose, glycohemoglobin, hsCRP, cholesterol, LDL-cholesterol and triglycerides levels, and increase of HDL-cholesterol, levels of vitamins D and B9.…”

“…Kirillova et al demonstrated a negative correlation between adiponectin level and BMI in morbidly obese patients, which is congruent with our data [ 31 ]. Adiponectin is important in transporting glucose, regulating lipid metabolism and improving insulin sensitivity, which elicit an anti-inflammatory role in inhibiting the formation of atherosclerosis [ 28 , 32 , 33 ]. The revealed inverse correlation between adiponectin concentration and BMI in obese patients allows us to conclude that adipose tissue with increasing fat mass decreases fatty acid oxidation in muscles and liver, and this, apparently, contributes to lipid accumulation in the cells.…”

The Role of Adipokines in the Pathogenesis of Psoriasis

“…Liang et al suggested that chemerin levels in adipose tissue and peripheral blood were elevated in women with gestational diabetes [ 200 ]. Moreover observed that patients with type 2 diabetes present higher chemerin plasma levels compared to control groups [ 201 ], whereas Bobbert et al reported that chemerin might be a predictor of the disease [ 202 ]. In this context, it is interesting to note that Bozaoglu et al observed that chemerin positively correlates with waist-to-hip ratio, body mass index, glucose levels, blood pressure, and circulating triglycerides [ 203 ].…”

Impacts of Chemerin Levels and Antioxidant Capacity on the Severity of Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes and Prediabetes

“…Chemerin, an adipokine primarily expressed in adipose tissue, plays a pivotal role in adipocyte differentiation, development, and the modulation of glucose and lipid metabolism [9]. Elevated concentrations of chemerin have been documented in individuals affected by obesity, those in prediabetic states, and obese individuals with T2DM [10]. Conversely, thiols, which are characterized by the presence of sulfhydryl groups, fulfill a significant function in the attenuation of oxidative stress by combating reactive oxygen species.…”