Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload

Pimková, Kristýna; Chrastinová, Leona; Suttnar, Jiřı́; Štikarová, Jana; Kotlín, Roman; Čermák, Jaroslav; Dyr, Jan E.

doi:10.1155/2014/416028

Cited by 22 publications

(21 citation statements)

References 39 publications

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“…Also, our study showed that the bilirubin system of HL patients seems to be affected by their oxidative status. Regarding MDS patients, Pimkova et al 23 did not observe increased MDA levels which contrasts with our findings in this group of patients. But, Goncalves et al 16 in agreement with our study observed increased ROS levels and consequently the involvement of oxidative stress to the development of MDS.…”

Section: Discussioncontrasting

confidence: 99%

“…Among them, myelodysplastic syndromes (MDS) represent a unique scenario as oxidative stress can increase due to both transfusion-dependent iron overload and dyserythropoiesis itself. 16 Publications from different groups have presented measurements of different oxidative stress biomarkers for different hematological malignancies such as acute lymphoblastic leukemia (ALL), Hodgkin lymphoma (HL) and Myelodysplastic syndromes [17][18][19][20][21][22][23] . Battisti et al measured plasmatic thiobarbituric acid-reactive substances (TBARS), serum protein carbonylation, whole blood catalase (CAT) and superoxide dismutase (SOD) activities in ALL patients 22 .…”

Section: Introductionmentioning

confidence: 99%

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Correlation of Oxidative Stress Biomarkers and Hematological Parameters in Blood Cancer Patients from Sardinia, Italy

Tsamesidis¹,

Pantaleo²,

Pekou³

et al. 2019

IJHOSCR

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Background: Over the last few decades, there has been a dramatic increase in hematological malignancies (HMs) in the population of Sardinia. It is accepted that oxidative stress biomarkers have been demonstrated to be prognostically important in various neoplastic diseases. The aim of this study is to evaluate serum vitamin E, total antioxidant capacity (TAC), Malondialdehyde (MDA) and reactive oxygen species (ROS) levels in 80 Sardinian patients with different HMs [acute myeloid leukemia (AML)(n=20), myelodysplastic syndromes (MDS) (n=20), Hodgkin lymphoma (HL) (n=20) and non-Hodgkin lymphoma (NHL) (n=20)] on the day of their diagnosis. Materials and Methods: Samples from all participants were obtained after an overnight fast (at least 10 hours). This study was approved and conducted in accordance with Good Clinical Practice guidelines and the Declaration of Helsinki. Patients and controls provided written, informed consent before entering the study. All study participants’ medical history and their medication were documented upon enrolling. Results: Lower levels of TAC and Vitamin E were observed in most of the studied groups compared to healthy controls (0.41-0.49 mmol/L vs. 0.56 mmol/L) (19.55-28.55 μmol/L vs. 34.51 μmol/L). Moreover, higher average MDA levels were observed in HL and NHL patients compared to healthy controls (16.6 ng/ml-17.8 ng/ml vs. 7.4 ng/ml). Additionally, the ROS values of all studied groups were found elevated. Serum TAC showed significant negative correlations with MDA values (R= -0.51; P<0.001). Statistical significance was observed in all hematological parameters, producing either positive or negative correlation with at least one OS biomarker. Conclusion: The present data suggest that Sardinian patients with HL and NHL on the day of their diagnosis presented the highest OS in comparison to AML and healthy subjects. Moreover, MDS patients presented high OS status. Likewise, our results also indicated that changes in their hematological indices are eminent of their oxidative and antioxidative status.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlation of Oxidative Stress Biomarkers and Hematological Parameters in Blood Cancer Patients from Sardinia, Italy

Tsamesidis¹,

Pantaleo²,

Pekou³

et al. 2019

IJHOSCR

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“…Pimkova et al [ 41 ] reported that mean plasma tHcy of 14.5 μmol/L in patients with myelodysplastic syndromes was greater than that of 9.4 μmol/L in healthy controls. In these patients, mean plasma ferritin was elevated (although not significantly), whereas plasma iron was normal.…”

Section: Iron-hcy Interactionmentioning

confidence: 99%

Homocysteine, Iron and Cardiovascular Disease: A Hypothesis

Baggott

Tamura

2015

Nutrients

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Elevated circulating total homocysteine (tHcy) concentrations (hyperhomocysteinemia) have been regarded as an independent risk factor for cardiovascular disease (CVD). However, several large clinical trials to correct hyperhomocysteinemia using B-vitamin supplements (particularly folic acid) have largely failed to reduce the risk of CVD. There is no doubt that a large segment of patients with CVD have hyperhomocysteinemia; therefore, it is reasonable to postulate that circulating tHcy concentrations are in part a surrogate marker for another, yet-to-be-identified risk factor(s) for CVD. We found that iron catalyzes the formation of Hcy from methionine, S-adenosylhomocysteine and cystathionine. Based on these findings, we propose that an elevated amount of non-protein-bound iron (free Fe) increases circulating tHcy. Free Fe catalyzes the formation of oxygen free radicals, and oxidized low-density lipoprotein is a well-established risk factor for vascular damage. In this review, we discuss our findings on iron-catalyzed formation of Hcy from thioethers as well as recent findings by other investigators on this issue. Collectively, these support our hypothesis that circulating tHcy is in part a surrogate marker for free Fe, which is one of the independent risk factors for CVD.

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“…Williams et al [46] in a comparative study of plasma aminothiols between healthy subjects and stroke patients observed elevated t-Hcy (9.9 § 0.6 mM/L) among stroke patients than the healthy control (6.5 § 0.3mM/L). Elevated levels of plasma t-Hcy were also reported in myelodysplastic patients compared to the healthy blood donors by Pimkova et al, [47] Pfeiffer et al [37] reported plasma t-Hcy and L-Cys concentrations for healthy males and females, respectively, in the order of 9.1 § 1.8 and 298 § 29 mM/L for males and 7.8 § 1.7 mM/L and 280 § 32 mM/L for females. Higher plasma t-Hcy values in the order of 11.69 § 2.32 mM/L for male and 9.45 § 1.78 mM/L for female were reported in healthy control subjects by Tokgoz et al [44] in their comparative study in patients having atherosclerosis, hypogonadism and Behcet's disease.…”

Section: Discussionmentioning

confidence: 66%

Plasma-aminothiols status and inverse correlation of total homocysteine with B-vitamins in arsenic exposed population of West Bengal, India

Mukherjee

Manna

Chakraborty

et al. 2016

Journal of Environmental Science and Health, Part A

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Chronic arsenic toxicity is a serious environmental health problem across the world. Bangladesh and India (particularly the state of West Bengal) are the worst affected countries with such problem. The present study reports plasma-aminothiols (p-aminothiols) like L-cysteine (L-Cys), cysteinyl glycine (Cys-gly), total homocysteine (t-Hcy) and glutathione (GSH) status, and the inverse relationship of t-Hcy with B-vitamins (B1, B6, B9 and B12) in arsenic exposed population of West Bengal, India. Reverse phase HPLC was used to measure p-aminothiols and serum B-vitamins in different arsenic exposed population. Arsenic in drinking water and urine were measured by flow injection analysis system - Atomic Absorption Spectrometry (FIAS-AAS) and Transversely heated graphite atomizer (THGA-AAS) techniques, respectively. Water arsenic exposure was >50 µg/L in 50% population, of which majority (33.58%) belong to the range of >50-500 µg/L and more than 8% were even >1000 µg/L. Urine arsenic (µg/g creatinine) levels increased with arsenic exposure. The variability among p-aminothiols was also observed with higher exposure to arsenic in drinking water. A significant difference between exposed and control population was noticed for plasma L-Cys. The difference of B-vitamins between the population exposed to <50 and >50 µg/L arsenic in drinking water was also found to be significant. B9 and B12 deficiency with increased consumption of arsenic in water corroborates the anemic conditions commonly observed among arsenic exposed population. The aminothiol status indicated oxidative stress in exposed population. This study demonstrated progressive increase in plasma t-Hcy as well as inverse relationships of serum B-vitamins with increased water arsenic concentration.

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Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload

Cited by 22 publications

References 39 publications

Correlation of Oxidative Stress Biomarkers and Hematological Parameters in Blood Cancer Patients from Sardinia, Italy

Correlation of Oxidative Stress Biomarkers and Hematological Parameters in Blood Cancer Patients from Sardinia, Italy

Homocysteine, Iron and Cardiovascular Disease: A Hypothesis

Plasma-aminothiols status and inverse correlation of total homocysteine with B-vitamins in arsenic exposed population of West Bengal, India

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