Plasma Levels of Conjugated Bile Acids in Newborns After a Short Period of Parenteral Nutrition

D’Apolito, Oceania; Pianese, Pierluigi; Salvia, G.; Campanozzi, Angelo; Pettoello-Mantovani, Massimo; Russo, Antonio Dello; Corso, Gaetano

doi:10.1177/0148607110374059

Cited by 12 publications

(9 citation statements)

References 22 publications

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“…Clinical evidence is very limited, and results on the correlation between phytosterols and cholestasis are controversial. There is evidence that reduced enterohepatic circulation of bile acids in short‐bowel syndrome (SBS) and increased levels of phytosterols, which are contained in many parenteral lipid emulsions, might increase the risk of cholestasis in pediatric patients or patients receiving long‐term PN . Over time, the phytosterol content in ILE can exceed the body's capacity for disposal via biliary secretion and loss from skin and gut mucosa, leading to increased phytosterol content of plasma lipoproteins and cell membranes—especially in children.…”

Section: Intestinal Failure Associated Liver Diseasementioning

confidence: 99%

Use of Lipids in Adult Patients Requiring Parenteral Nutrition in the Home Setting

Mundi

Kłęk²,

Martindale

2020

J Parenter Enteral Nutr

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It is estimated that over 25,000 Americans receive home parenteral nutrition (HPN), mostly because of intestinal failure (IF). Although there is significant variability in the fluid and energy needs of patients receiving HPN, intravenous lipid emulsions (ILEs) are an essential part of the macronutrient composition, serving as an excellent source of non‐protein energy, as well as supplying essential fatty acids. However, the long‐term use of ILEs in particular may be associated with some detrimental health effects, such as intestinal failure associated liver disease (IFALD). Although there is lack of unifying diagnosis, IFALD can present as cholestasis, steatosis, or fibrosis, with a prevalence that ranges between 5% and 43%. The development of IFALD tends to be multifactorial. Risk factors of IFALD can include those related to IF, inflammation/infection, and long‐term parenteral nutrition. Some studies have shown a link between development of IFALD and ILE dose, especially if the dose is >1 g/kg/d, with high ω‐6:ω‐3 polyunsaturated fatty acid (PUFA) ratio and phytosterol content being theorized as some contributing factors. Thus, efforts have been made to use alternative oils (olive oil, medium‐chain triglycerides, and fish oil) to reduce the soybean‐oil content of ILE, which tends to be high in ω‐6 PUFA and phytosterols. Although additional long‐term clinical data are emerging, this strategy, as reviewed in the current manuscript, has shown to provide some benefit in both prevention and treatment of IFALD and other sequelae of HPN.

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Section: Intestinal Failure Associated Liver Diseasementioning

confidence: 99%

Use of Lipids in Adult Patients Requiring Parenteral Nutrition in the Home Setting

Mundi

Kłęk²,

Martindale

2020

J Parenter Enteral Nutr

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“…In preterm infants, fluids containing lipids added to parenteral nutrition may lead to hepatocyte demage and as a result cholestatic hepatic disease may develop (47).…”

Section: Idiopathicmentioning

confidence: 99%

Yenidoğan ve süt çocukluğunda kolestaz

Çokuğraş¹,

Beşer²

2012

tpa

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Review Sum maryDuring the newborn and infancy period, it is an important to demonstrate the condition which causes cholestatic liver diseases. If direct bilirubin level is more than 20% of total biluribin, it is defined as cholestasis. Especially early diagnosis of diseases including biliary atresia, tyrosinaemia, galactosemia is crucial for prevention of permanent damage in the future and for benefit from early treatment. Therefore, total, direct and indirect bilirubin levels should be measured in all newborns with jaundice lasting longer than two weeks. If 20% of total bilirubin is direct bilirubin, liverrelated disorders should be questioned. In this review, we aimed to show which clinical and laboratory features should be considered to demonstrate the cause of cholestatic diseases. (Turk Arch Ped 2012; 47: 1-7)

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“…In this issue of the Journal of Parenteral and Enteral Nutrition (JPEN) , D'Apolito and colleagues 1 report the results of a study examining the amount of conjugated bile acids (BAs) in the plasma of healthy newborn infants and other patients before and after parenteral nutrition (PN) administration. The study group included 22 term and preterm newborns (group T1) who had received at least 75% of the required energy via parenteral nutrition for 3–15 days.…”

mentioning

confidence: 99%

“…D'Apolito and colleagues 1 must be credited for the implementation of a novel conjugated BA measurement method in this group of neonates. HPLC‐MS seems to be an accurate assay.…”

mentioning

confidence: 99%

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Conjugated Bile Acids as Potential Early Markers of Parenteral Nutrition–Associated Liver Disease

Ovchinsky

2010

J Parenter Enteral Nutr

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Plasma Levels of Conjugated Bile Acids in Newborns After a Short Period of Parenteral Nutrition

Abstract: In newborns receiving PN, a short period of PN is associated with an early increase of some conjugated BA. These results suggest that GCA, TCA, and TCDCA+TDCA+TUDCA levels could be used as early markers of PN-related cholestasis.

Cited by 12 publications

References 22 publications

Use of Lipids in Adult Patients Requiring Parenteral Nutrition in the Home Setting

Use of Lipids in Adult Patients Requiring Parenteral Nutrition in the Home Setting

Yenidoğan ve süt çocukluğunda kolestaz

Conjugated Bile Acids as Potential Early Markers of Parenteral Nutrition–Associated Liver Disease

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