Plasma levels of endothelin-1 and renal function among young and healthy adults

Fischer, Andreas; Bossard, Matthias; Aeschbacher, Stefanie; Egli, Peter; Cordewener, Carolin; Estis, Joel; Todd, John; Risch, Martin; Risch, Lorenz; Conen, David

doi:10.1515/cclm-2016-0920

Cited by 6 publications

(6 citation statements)

References 37 publications

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“…It is produced by almost all cell types in the kidney. The involvement of the ET‐1 system in the regulation of renal function was reported previously . ET‐1 was reported as a good indicator of early renal injury, and it can facilitate the evaluation of treatment outcomes .…”

Section: Introductionsupporting

confidence: 80%

“…ET‐1 was reported as a good indicator of early renal injury, and it can facilitate the evaluation of treatment outcomes . A close link between serum ET‐1 and renal function in healthy young people and CKD was reported previously. Renal injury is initially characterized by renal tubular cell apoptosis and nephron loss.…”

Section: Introductionmentioning

confidence: 99%

“…The involvement of the ET-1 system in the regulation of renal function was reported previously. [25][26][27][28] ET-1 was reported as a good indicator of early renal injury, and it can facilitate the evaluation of treatment outcomes. 27 A close link between serum ET-1 and renal function in healthy young people 28 and CKD 25 was reported previously.…”

Section: Introductionmentioning

confidence: 99%

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Acute renal impairment characterization using diffusion magnetic resonance imaging: Validation by histology

Zhu

et al. 2019

NMR in Biomedicine

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Diffusion magnetic resonance imaging has been demonstrated to be a simple, noninvasive and accurate method for the detection of renal microstructure and microcirculation, which are closely linked to renal function. Moreover, serum endothelin‐1 (ET‐1) was also reported as a good indicator of early renal injury. The aim of this study was to evaluate the feasibility and capability of diffusion MRI and ET‐1 to detect acute kidney injury by an operation simulating high‐pressure renal pelvic perfusion, which is commonly used during ureteroscopic lithotripsy. Histological findings were used as a reference. Fourteen New Zealand rabbits in an experimental group and 14 in a control group were used in this study. Diffusion tensor imaging and intravoxel incoherent motion diffusion‐weighted imaging were acquired by a 3.0 T MRI scanner. Significant corticomedullary differences were found in the values of the apparent diffusion coefficient (ADC), pure tissue diffusion, volume fraction of pseudo‐diffusion (fp) and fractional anisotropy (FA) (P < 0.05 for all) in both preoperation and postoperation experimental groups. Compared with the control group, the values of cortical fpmean, medullary ADCmean and FAmean decreased significantly (P < 0.05) after the operation in the experimental group. Also, the change rate of medullary ADCmean in the experimental group was more pronounced than that in the control group (P = 0.018). No significant change was found in serum ET‐1 concentration after surgery in either the experimental (P = 0.80) or control (P = 0.17) groups. In the experimental group, histological changes were observed in the medulla, while no visible change was found in the cortex. This study demonstrated the feasibility of diffusion MRI to detect the changes of renal microstructure and microcirculation in acute kidney injury, with the potential to evaluate renal function. Moreover, the sensitivity of diffusion MRI to acute kidney injury appears to be superior to that of serum ET‐1.

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Section: Introductionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acute renal impairment characterization using diffusion magnetic resonance imaging: Validation by histology

Zhu

et al. 2019

NMR in Biomedicine

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“…8 Endothelin-1 is a peptide which has vasoconstrictive, inflammatory, and mitogenic activities. 4 The pathophysiological pathways of autosomal dominant polycystic renal disease; compression of the renal vasculature leads to ischemia, hypoxia and activation of renin-angiotensin system increases the ET-1 synthesis. 6 Endothelin-1 stimulate cyst growth and interstitial fibrosis through ET-A and ET-B receptors with vasopressin dependent and independent mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…3 Endothelin-1 is vasoconstrictive, inflammatory and mitogenic peptide and elevated ET-1 levels are associated with hypertension, endothelial dysfunction and atherosclerosis. 4 In addition, ET-1 directly promotes mesangial cell proliferation and involves in matrix protein biosynthesis in kidney. 5 The progressive cyst enlargement causes the stimulation of intrarenal renin-angiotensin-aldosterone system thus resulting in the increased sympathetic activity and ET-1 levels in autosomal dominant polycystic kidney disease (PKD) leading to systemic hypertension.…”

Section: Introductionmentioning

confidence: 99%

Endothelin-1 Level in Patients with Simple Renal Cyst

Çalışkan

Sungur

Eser

et al. 2019

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Introduction: Endothelin-1 (ET-1) is potent vasoconstrictive peptide and elevated ET-1 levels are associated with hypertension, endothelial dysfunction and atherosclerosis. Research on (ET-1) has demonstrated that elevated ET-1 levels in autosomal dominant polycystic kidney disease leads to systemic hypertension. The prevalence of simple renal cysts increases with age and the association with simple renal cyst and hypertension is not clear. The aim of this study was to investigate the ET-1 levels in patients with simple renal cyst and compare them with those in healthy adults. Materials and methods: The study included patients that underwent laparoscopic renal cyst decortication in the Department of Urology and healthy controls. Serum and urinary ET-1 levels were measured before surgery and one month after it in the patients with simple renal cyst. Serum ET-1 levels were measured in healthy adult patients. Ambulatory blood pressure was measured in all patients. Glomerular filtration rate was measured according to the chronic kidney disease epidemiology collaboration formula. Results: Thirty-two patients were included in the present study. Of these, 16 patients with simple renal cyst were allocated into group 1 and 16 healthy patients - in group 2. There was no significant difference between systolic and diastolic blood pressure between the groups (p=0.820 and p=0.618, respectively). Serum EL-1 levels were significantly lower in group 1 than those in group 2 (p=0.036). Interestingly, serum EL-1 levels were increased after laparoscopic cyst decortication and there was no significant difference with healthy patients (p=0.429). Conclusions: The present study demonstrated that serum EL-1 level in patients with simple renal cyst was lower than that in healthy people. Further studies are needed to investigate the EL-1 levels in simple renal cyst patients.

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Early and Late Stages of Chronic Kidney Disease in Relation to Arterial Changes

Laucyte-Cibulskiene,

Gottsäter

2024

Early Vascular Aging (EVA)

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Plasma levels of endothelin-1 and renal function among young and healthy adults

Cited by 6 publications

References 37 publications

Acute renal impairment characterization using diffusion magnetic resonance imaging: Validation by histology

Acute renal impairment characterization using diffusion magnetic resonance imaging: Validation by histology

Endothelin-1 Level in Patients with Simple Renal Cyst

Early and Late Stages of Chronic Kidney Disease in Relation to Arterial Changes

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