Plasma Levels of Inflammatory Markers Neopterin, Sialic Acid, and C-Reactive Protein in Pregnancy and Preeclampsia

Versen-Hoeynck, Frauke M. von; Hubel, Carl A.; Gallaher, Marcia J.; Gammill, Hilary S.; Powers, Robert W.

doi:10.1038/ajh.2009.54

Cited by 74 publications

(49 citation statements)

References 35 publications

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“…We observed the systemic inflammatory response in pre-eclampsia through hs-CRP which is similar to the research reports of von Versen-Hoeynck 2009 [22], Belo 2009 [23]. The increase in plasma elastase in early onset of pre-eclampsia has been reported by Gupta 2006 [24].…”

Section: Discussionsupporting

confidence: 79%

Phospholipase a 2 , Plasma Elastase Activity in Pre- And Post-Partum of Pre-Eclamptic Women

Dayanand

Bambrana

Sheela

2016

Asian J Pharm Clin Res

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Objective: The objectives of the present study were to evaluate the activity of phospholipase A 2 , plasma elastase enzymes and to assess relation with an inflammatory marker high sensitive C-reactive protein (hs-CRP) in nonpregnant before and after delivery of normotensive pregnant and preeclamptic women. Methods:The study population consists of three groups: Nonpregnant (Group 1, n=57), normotensive pregnant (Group 2, n=57), and pre-eclamptic women (Group 3, n=57). Groups 2 and 3 were followed after delivery within 48 hrs. Phospholipase A 2 , plasma elastase, and hs-CRP levels were determined spectrophotometrically. Results:The plasma elastase, phospholipase A 2 activity, and hs-CRP were elevated in pre-eclampsia significantly (p<0.05), nonsignificant rise in normotensive pregnant before delivery condition compared to nonpregnant women. However, plasma elastase in normal pregnancy and pre-eclampsia were decreased by 1.2-and 2.07-fold, respectively, after delivery. Whereas phospholipase A 2 and hs-CRP found to be nonsignificantly decreased in the postdelivery status of the both the groups. Receiver operating characteristics curve analysis showed that elastase enzyme has diagnostic importance to assess inflammation on the basis of area under curve (0.758). Conclusion:Our research findings generated knowledge about raised level of plasma elastase enzyme by neutrophil degranulation represents inflammation in pre-eclampsia. Elevated elastase, phospholipase A 2 with hs-CRP in pre-eclampsia serves as indicators of inflammation.

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Section: Discussionsupporting

confidence: 79%

Phospholipase a 2 , Plasma Elastase Activity in Pre- And Post-Partum of Pre-Eclamptic Women

Dayanand

Bambrana

Sheela

2016

Asian J Pharm Clin Res

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“…Thirty‐two studies in total reported on C‐reactive protein levels,21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52 of which 17 were applicable for meta‐analysis 21, 22, 23, 29, 30, 31, 32, 33, 34, 37, 38, 39, 41, 42, 47, 49, 50. A significantly higher C‐reactive protein was found in women with pre‐eclampsia than in non‐hypertensive controls ( Figure 2), and this correlation was stronger in severe than in mild pre‐eclampsia ( Figure 3).…”

Section: Resultsmentioning

confidence: 99%

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

et al. 2017

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Evidence accumulates for associations between hypertensive pregnancy disorders and increased cardiovascular risk later. The main goal of this study was to explore shared biomarkers representing common pathogenic pathways between heart failure with preserved ejection fraction (HFpEF) and pre‐eclampsia where these biomarkers might be potentially eligible for cardiovascular risk stratification in women after hypertensive pregnancy disorders. We sought for blood markers in women with diastolic dysfunction in a first literature search, and through a second search, we investigated whether these same biochemical markers were present in pre‐eclampsia.This systematic review and meta‐analysis presents two subsequent systematic searches in PubMed and EMBASE. Search I yielded 3014 studies on biomarkers discriminating women with HFpEF from female controls, of which 13 studies on 11 biochemical markers were included. Cases had HFpEF, and controls had no heart failure. The second search was for studies discriminating women with pre‐eclampsia from women with non‐hypertensive pregnancies with at least one of the biomarkers found in Search I. Search II yielded 1869 studies, of which 51 studies on seven biomarkers were included in meta‐analyses and 79 studies on 12 biomarkers in systematic review.Eleven biological markers differentiated women with diastolic dysfunction from controls, of which the following 10 markers differentiated women with pre‐eclampsia from controls as well: C‐reactive protein, HDL, insulin, fatty acid‐binding protein 4, brain natriuretic peptide, N terminal pro brain natriuretic peptide, adrenomedullin, mid‐region pro adrenomedullin, cardiac troponin I, and cancer antigen 125.Our study supports the hypothesis that HFpEF in women shares a common pathogenic background with pre‐eclampsia. The biomarkers representing inflammatory state, disturbances in myocardial function/structure, and unfavourable lipid metabolism may possibly be eligible for future prognostic tools.

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“…50 Inflammation is increased in women with preeclampsia, with activated macrophages and monocytes being further increased. 52 Circulating levels of IL-1b and TNF-a are elevated in preeclampsia, 53 and infusion of a low dose of lipopolysaccharide in rats at 14 days gestation establishes a preeclampsia model with hypertension and albuminuria. 54 There is evidence to link inflammation with the modulation of differentiation in BeWo cells and trophoblast cells.…”

Section: Discussionmentioning

confidence: 99%

TREM-1 Expression Is Increased in Human Placentas From Severe Early-Onset Preeclamptic Pregnancies Where It May Be Involved in Syncytialization

2014

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Preeclampsia, a major cause of maternal and perinatal morbidity and mortality, is thought to be attributable to dysregulation of trophoblast invasion and differentiation. Microarray studies have shown that triggering receptor expressed on myeloid cells (TREM) 1, a cell surface molecule involved in the inflammatory response, is increased in preeclamptic placentas. The aim of this study was to determine the level of TREM-1 expression in severe early-onset preeclamptic placentas and its functional role in trophoblast differentiation. Placenta was obtained from women with severe early-onset preeclampsia (n ¼ 19) and gestationally matched preterm controls placentas (n ¼ 8). The TREM-1 expression was determined by quantitative reverse transcriptase polymerase chain reaction and Western blotting. The effect of TREM-1 small interfering RNA on cell fusion and differentiation was assessed in BeWo cells. The effect of oxygen tension on TREM-1 levels, in basal or forskolin-treated BeWo cells, was also assessed. The TREM-1 was localized to the syncytiotrophoblast layer, and TREM-1 messenger RNA and protein expression was significantly increased in preeclamptic placentas. The BeWo cells treated with forskolin were associated with increased TREM-1 expression. The TREM-1 knockdown inhibited forskolin-induced expression of the differentiation marker b-human chorionic gonadotropin but had no effect on the cell-fusion marker E-cadherin. The increase in TREM-1 expression in BeWo cells treated with forskolin during normoxic conditions was reduced in forskolin-treated cells under hypoxic conditions. In conclusion, TREM-1 is increased in preeclamptic placentas and by forskolin treatment. Knockdown of TREM-1 by RNA interference inhibits cell differentiation but has no effect on cell-cell fusion. Finally, we show that TREM-1 upregulation is attenuated under hypoxic conditions in which cell differentiation is impaired.

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Plasma Levels of Inflammatory Markers Neopterin, Sialic Acid, and C-Reactive Protein in Pregnancy and Preeclampsia

Cited by 74 publications

References 35 publications

Phospholipase a 2 , Plasma Elastase Activity in Pre- And Post-Partum of Pre-Eclamptic Women

Phospholipase a 2 , Plasma Elastase Activity in Pre- And Post-Partum of Pre-Eclamptic Women

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

TREM-1 Expression Is Increased in Human Placentas From Severe Early-Onset Preeclamptic Pregnancies Where It May Be Involved in Syncytialization

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