Plasma levels of leptin and adiponectin and depressive symptoms in young adults

Syk, Mikaela; Ellström, Sofie; Mwinyi, Jessica; Schiöth, Helgi B.; Ekselius, Lisa; Ramklint, Mia; Cunningham, Janet L.

doi:10.1016/j.psychres.2018.11.075

Cited by 23 publications

(15 citation statements)

References 58 publications

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“…For instance, a meta‐analysis has shown a significant association between depression and adiponectin levels with patients of European descent suffering from depression because of having lower levels of the hormone (Hu et al., 2015). On the other hand, a cross‐sectional observational study found no significant association between the plasma adiponectin levels and depressive symptoms although the participants of this study only included young adults (Syk et al., 2019). There is evidence of confounding factors such as age and body mass index (BMI) influencing the association.…”

Section: Physiological Factors That Play Key Roles In the Comorbiditymentioning

confidence: 75%

Pathophysiology linking depression and type 2 diabetes: Psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

Subba

Sandhir

Singh

et al. 2021

Eur J of Neuroscience

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Diabetes increases the likelihood of developing depression and vice versa. Research on this bidirectional association has somewhat managed to delineate the interplay among implicated physiological processes. Still, further exploration is required in this context. This review addresses the comorbidity by investigating suspected common pathophysiological mechanisms. One such factor is psychological stress which disturbs the hypothalamic–pituitary–adrenal axis causing hormonal imbalance. This includes elevated cortisol levels, a common biomarker of both depression and diabetes. Disrupted insulin signaling drives the hampered neurotransmission of serotonin, dopamine, and norepinephrine. Also, adipokine hormones such as adiponectin, leptin, and resistin and the orexigenic hormone, ghrelin, are involved in both depression and T2DM. This disarray further interferes with physiological processes encompassing sleep, the gut–brain axis, metabolism, and mood stability. Behavioral coping mechanisms, such as unhealthy eating, mediate disturbed glucose homeostasis, and neuroinflammation. This is intricately linked to oxidative stress, redox imbalance, and mitochondrial dysfunction. However, interventions such as psychotherapy, physical exercise, fecal microbiota transplantation, and insulin‐sensitizing agents can help to manage the distressing condition. The possibility of glucagon‐like peptide 1 possessing a therapeutic role has also been discussed. Nonetheless, there stands an urgent need for unraveling new correlating targets and biological markers for efficient treatment.

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Section: Physiological Factors That Play Key Roles In the Comorbiditymentioning

confidence: 75%

Pathophysiology linking depression and type 2 diabetes: Psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

Subba

Sandhir

Singh

et al. 2021

Eur J of Neuroscience

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“…On the other hand, some studies found that patients with depressed mood had higher levels of leptin than a control group [45]. A recently published study analysing plasma levels of leptin in young adults revealed a positive association between plasma leptin levels and selfreported depressive symptoms, especially for women [57]. Indeed, several previous studies displayed a clear sex difference of leptin levels, with females having higher amount than males [57][58][59].…”

Section: Leptin and Psychiatric Illnessesmentioning

confidence: 97%

“…A recently published study analysing plasma levels of leptin in young adults revealed a positive association between plasma leptin levels and selfreported depressive symptoms, especially for women [57]. Indeed, several previous studies displayed a clear sex difference of leptin levels, with females having higher amount than males [57][58][59]. Carvalho et al in their meta-analytic study published in 2014, found higher peripheral leptin levels in participants with mild to moderate major depressive disorder compared with controls, but no significant difference between controls and severely depressed patients [60].…”

Section: Leptin and Psychiatric Illnessesmentioning

confidence: 99%

Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

et al. 2020

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Antipsychotic-induced weight gain is the most prevalent somatic adverse event occurring in patients treated by antipsychotics, especially atypical antipsychotics. It is of particular interest because of its repercussion on cardiovascular morbidity and mortality especially now that the use of second-generation antipsychotics has been extended to other mental health illnesses such as bipolar disorders and major depressive disorder. The mechanism underlying antipsychotics-induced weight gain is still poorly understood despite a significant amount of work on the topic. Recently, there has been an ongoing debate of tremendous research interest on the relationship between antipsychotic-induced weight gain and body weight regulatory hormones such as leptin. Given that, researchers have brought to light the question of leptin's role in antipsychotic-induced weight gain. Here we summarize and discuss the existing evidence on the link between leptin and weight gain related to antipsychotic drugs, especially atypical antipsychotics.

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“…On the other hand, some studies did not find any difference in the leptin levels between depressed patients and control group [ 100 , 101 , 102 , 103 ], or measured higher levels of leptin in depressed patients [ 104 , 105 , 106 , 107 , 108 , 109 ]. In addition, a positive association between circulating leptin levels and depressive symptoms [ 110 ], mild/moderate but not severe depression [ 104 , 111 ], and with self-reported depressive symptoms, especially in women [ 109 ], was recently identified. A marked sexual difference in leptin levels has been consistently reported, usually both healthy and depressed women have higher leptin levels than men [ 88 , 104 , 112 ].…”

Section: Adipokinesmentioning

confidence: 99%

Depression and Cardiovascular Disease: The Viewpoint of Platelets

Amadio

Zara

Sandrini

et al. 2020

IJMS

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Depression is a major cause of morbidity and low quality of life among patients with cardiovascular disease (CVD), and it is now considered as an independent risk factor for major adverse cardiovascular events. Increasing evidence indicates not only that depression worsens the prognosis of cardiac events, but also that a cross-vulnerability between the two conditions occurs. Among the several mechanisms proposed to explain this interplay, platelet activation is the more attractive, seeing platelets as potential mirror of the brain function. In this review, we dissected the mechanisms linking depression and CVD highlighting the critical role of platelet behavior during depression as trigger of cardiovascular complication. In particular, we will discuss the relationship between depression and molecules involved in the CVD (e.g., catecholamines, adipokines, lipids, reactive oxygen species, and chemokines), emphasizing their impact on platelet activation and related mechanisms.

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Plasma levels of leptin and adiponectin and depressive symptoms in young adults

Cited by 23 publications

References 58 publications

Pathophysiology linking depression and type 2 diabetes: Psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

Pathophysiology linking depression and type 2 diabetes: Psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

Depression and Cardiovascular Disease: The Viewpoint of Platelets

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